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8 results for “autoantibody signature”
Cystic fibrosis autoantibody signatures associate with Staphylococcus aureus lung infection or cystic fibrosis-related diabetes
<p>While cystic fibrosis (CF) lung disease is characterized by persistent inflammation and infections, and chronic inflammatory diseases are often accompanied by autoimmunity, autooimmune reactivity in CF has not been studied in depth. In this work, we undertook an unbiased approach to explore the systemic autoantibody repertoire in CF. Our results show higher levels of several new autoantibodies in the blood of people with CF (PwCF) compared to control subjects. Some of these are IgA autoantibodies targeting neutrophil components or autoantigens linked to neutrophil-mediated tissue damage in CF. We also found that PwCF with higher systemic IgM autoantibody levels have lower prevalence of <em>S. aureus</em> infection. On the other hand, IgM autoantibody levels in <em>S. aureus</em>-infected PwCF correlate with lung disease severity. Diabetic PwCF have significantly higher levels of IgA autoantibodies in their circulation compared to nondiabetic PwCF, and several of their IgM autoantibodies are associated with worse lung disease. In contrast, in nondiabetic PwCF blood levels of IgA autoantibodies correlate with lung disease. We have also identified other autoantibodies in CF that are associated with <em>P. aeruginosa</em> airway infection. In summary, we have identified several new autoantibodies and associations of autoantibody signatures with specific clinical features in CF.</p>
Cystic fibrosis autoantibody signatures associate with Staphylococcus aureus lung infection or cystic fibrosis-related diabetes
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Whole genome-derived tiled peptide arrays detect pre-diagnostic autoantibody signatures in non-small cell lung cancer
GEO Series GSE128077. Homo sapiens. 174 samples. Type: Protein profiling by protein array.
Combination of autoantibody signature with PSA level enables a highly accurate blood-based differentiation of prostate cancer patients from patients with benign prostatic hyperplasia
GEO Series GSE67068. Homo sapiens. 147 samples. Type: Protein profiling by protein array.
Discovery of tissue-specific proteomic signatures in juvenile dermatomyositis highlights pathways reflecting persistent disease activity, clinical heterogeneity, and myositis-specific autoantibody sub
GEO Series GSE308711. Homo sapiens. 88 samples. Type: Other.
Anti-IMP3 Autoantibody and MicroRNA Signature Blood Tests in Finding Metastasis in Patients With Localized or Metastatic Kidney Cancer
ClinicalTrials.gov study NCT00806650. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Autoantibody Signature in Cardiac Arrest
<p><strong>Background:</strong> Cardiac arrest is a tragic event that causes one death roughly every 90 seconds</p> <p>worldwide. Survivors generally undergo a work-up to identify the etiology of arrest. However, 5-</p> <p>10% of cardiac arrest remain unexplained. As cardiac arrhythmias mostly underlie cardiac arrest</p> <p>and increasing evidence strongly supports the involvement of autoantibodies in</p> <p>arrhythmogenesis, a large-panel autoantibody screening was performed in cardiac arrest patients.</p> <p><strong>Methods:</strong> This is an observational, cross-sectional study of patients from the Montreal Heart</p> <p>Institute (MHI) hospital cohort, a single center registry of participants. A peptide microarray was</p> <p>designed to screen for IgG targeting epitopes from all known cardiac ion channels with</p> <p>extracellular domains. Plasma samples from 23 patients with unexplained cardiac arrest were</p> <p>compared to 22 cardiac arrest cases of ischemic origin and a group of 29 age-, sex- and BMImatched</p> <p>healthy subjects. The false discovery rate (FDR), LASSO logistic regression and</p> <p>random forest methods were jointly carried out to find significant differential IgG responses.</p> <p><strong>Results: </strong>The autoantibody against the pore domain of the L-type voltage-gated calcium channel</p> <p>(Cav1.2) was consistently identified as a biomarker of idiopathic cardiac arrest (P=0.002,</p> <p>FDR=0.007, classification accuracies ≥0.83). Functional studies on human induced pluripotent</p> <p>stem cell-derived cardiomyocytes demonstrated that the anti-Cav1.2 IgG purified from patients</p> <p>with idiopathic cardiac arrest is proarrhythmogenic by reducing the action potential duration</p> <p>through calcium channel inhibition.</p> <p><strong>Conclusions: </strong>The present report addresses the concept of autoimmunity and cardiac arrest.</p> <p>Hitherto unknown autoantibodies targeting extracellular sequences of cardiac ion channels were</p> <p>detected. Moreover, the study identified an autoantibody signature specific to patients with</p> <p>cardiac arrest.</p>
Evaluation of autoantibody signatures in meningioma patients using human proteome array
GEO Series GSE83507. Homo sapiens. 30 samples. Type: Protein profiling by protein array.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
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DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.