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Dataset results
436 results for “autoimmune diseases”
KCNA2 IgG Autoimmunity In Neuropsychiatric Diseases
<p>One patient of the cohort (#25) received a temporal lobe biopsy to rule out a malignant disease. Histological and immunohistochemical images of diagnostic sections are shown. From these images regions of interest are shown in Figure 2.</p>
Natural Killer cells demonstrate distinct eQTL and transcriptome-wide disease associations, highlighting their role in autoimmunity.
<p><strong>Abstract</strong> </p> <p>Natural Killer (NK) cells are innate lymphocytes with central roles in immunosurveillance and are implicated in autoimmune pathogenesis. The degree to which regulatory variants affect NK gene expression is poorly understood. We performed expression quantitative trait locus (eQTL) mapping of negatively selected NK cells from a population of healthy Europeans (n=245). We find a significant subset of genes demonstrate eQTL specific to NK cells and these are highly informative of human disease, in particular autoimmunity. An NK cell transcriptome-wide association study (TWAS) across five common autoimmune diseases identified further novel associations at 27 genes. In addition to these <em>cis</em> observations, we find novel master-regulatory regions impacting expression of <em>trans</em> gene networks at regions including 19q13.4, the Killer cell Immunoglobulin-like Receptor (KIR) Region, <em>GNLY</em>, <em>MC1R</em> and<em> UVSSA</em>. Our findings provide new insights into the unique biology of NK cells, demonstrating markedly different eQTL from other immune cells, with implications for disease mechanisms.</p> <p><strong>Preprint</strong></p> <p>https://www.biorxiv.org/content/10.1101/2021.05.10.443088v1</p> <p><strong>Dataset</strong></p> <p>nk_raw_for_zenodo.txt: Matrix of raw gene expression at 47,209 probes in primary human NK cells from 245 healthy individuals of European ancestry. Gene expression is quantified using the Illumina HumanHT-12 v4 BeadChip gene expression array platform. Column names represent Array Address ID for each probe, and row names represent pseudonymised sample identifiers, which can be matched to sample genotypes. Sample genotypes are available at the European Genome-Phenome Archive with accession ID EGAS00000000109).</p> <p>probes_passing_QC.txt: List of probes passing quality control; probe sequences mapping to a unique genomic locus, and probe sequences not containing common genomic variation (minor allele frequency >1%), n=29,002. Column names are Array Address ID (probeID), Ensembl ID (ensembl), Gene ID (gene), and Illumina probe ID (ilmn). </p>
Analysis of gene expression in autoimmune and autoinflammatory diseases using GSEA
<p>This dataset contains the results of gene set enrichment analysis (GSEA) of gene expression in the studied diseases. The archive is organized in folders according the GEO accessions for the raw data (see table 1 of the main article). If multiple diseases were studied within one GEO data series, GSEA was performed for each disease separately. Healthy subject data included in each data series were used as reference. </p> <p>For example <strong><em>"GSE3365.IBD"</em></strong> folder contains GSEA for Crohn's disease (CD) and ulcerative colitis (US). The <em><strong>"results"</strong></em> folder in <em><strong>"GSE3365.IBD"</strong></em> contains two subfolders <strong><em>"GSE3365CDvcHC"</em></strong> and <em><strong>"GSE3365UCvcHC"</strong></em>, respectively. The results can be browsed with <em><strong>"index.html"</strong></em> files located in each subfolder. </p>
Sirolimus for Autoimmune Disease of Blood Cells
ClinicalTrials.gov study NCT00392951. IPD Sharing: Not stated. Countries: 1. Publications: 4.
COVID-19 Booster Vaccine in Autoimmune Disease Non-Responders
ClinicalTrials.gov study NCT05000216. IPD Sharing: YES. Countries: 1. Publications: 1.
Vitamin D and Fish Oil for Autoimmune Disease, Inflammation and Knee Pain
ClinicalTrials.gov study NCT01351805. IPD Sharing: Not stated. Countries: 1. Publications: 5.
A-LiNK: Improving Outcomes in Autoimmune Liver Disease
ClinicalTrials.gov study NCT05750498. IPD Sharing: YES. Countries: 1. Publications: 0.
A Clinical Trial of Anakinra for Steroid-Resistant Autoimmune Inner Ear Disease
ClinicalTrials.gov study NCT01267994. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Relevance of Monitoring Blood and Salivar Levels of Drugs Used in Rheumatic Autoimmune Diseases
ClinicalTrials.gov study NCT03122431. IPD Sharing: NO. Countries: 1. Publications: 20.
Study to Assess the Safety, Tolerability, Efficacy and PK of APL-2 in Patients With Warm Type Autoimmune Hemolytic Anemia (wAIHA) or Cold Agglutinin Disease (CAD)
ClinicalTrials.gov study NCT03226678. IPD Sharing: NO. Countries: 1. Publications: 1.
The extrafollicular response is sufficient to drive initiation of autoimmunity and early disease hallmarks of lupus
Open the record for dataset details and reuse information.
Sex-Based Differences in Thyroid Plasma B Cell Infiltration: Implications for Autoimmune Disease Susceptibility - Table S1
<p>This is the supplementary table for the manuscript entitled "Sex-Based Differences in Thyroid Plasma B Cell Infiltration: Implications for Autoimmune Disease Susceptibility"</p>
Data from: Lupus and inflammatory bowel disease share a common set of microbiome features distinct from other autoimmune disorders
<p>Supplemental data for "Lupus and inflammatory bowel disease share a common set of microbiome features distinct from other autoimmune disorders"</p>
Dataset related to article "Dose-Dependent Impairment of the Immune Response to the Moderna-1273 mRNA Vaccine by Mycophenolate Mofetil in Patients with Rheumatic and Autoimmune Liver Diseases"
<p>This record contains data related to article “Dose-Dependent Impairment of the Immune Response to the Moderna-1273 mRNA Vaccine by Mycophenolate Mofetil in Patients with Rheumatic and Autoimmune Liver Diseases”</p> <p>The purpose of this study was to evaluate the efficacy and safety of the Moderna-1273 mRNA vaccine for SARS-CoV-2 in patients with immune-mediated diseases under different treatments. Anti-trimeric spike protein antibodies were tested in 287 patients with rheumatic or autoimmune diseases (10% receiving mycophenolate mofetil, 15% low-dose glucocorticoids, 21% methotrexate, and 58% biologic/targeted synthetic drugs) at baseline and in 219 (76%) 4 weeks after the second Moderna-1273 mRNA vaccine dose. Family members or caretakers were enrolled as the controls. The neutralizing serum activity against SARS-CoV-2-G614, alpha, and beta variants in vitro and the cytotoxic T cell response to SARS-CoV-2 peptides were determined in a subgroup of patients and controls. Anti-SARS-CoV-2 antibody development, i.e., seroconversion, was observed in 69% of the mycophenolate-treated patients compared to 100% of both the patients taking other treatments and the controls (<em>p</em> &lt; 0.0001). A dose-dependent impairment of the humoral response was observed in the mycophenolate-treated patients. A daily dose of &gt;1 g at vaccination was a significant risk factor for non-seroconversion (ROC AUC 0.89, 95% CI 0.80-98, <em>p</em> &lt; 0.0001). Moreover, in the seroconverted patients, a daily dose of &gt;1 g of mycophenolate was associated with significantly lower anti-SARS-CoV-2 antibody titers, showing slightly reduced neutralizing serum activity but a comparable cytotoxic response compared to other immunosuppressants. In non-seroconverted patients treated with mycophenolate at a daily dose of &gt;1 g, the cytotoxic activity elicited by viral peptides was also impaired. Mycophenolate treatment affects the Moderna-1273 mRNA vaccine immunogenicity in a dose-dependent manner, independent of rheumatological disease.</p> <p>.</p>
Safety Study of CC312 in Autoimmune Disease Patients
ClinicalTrials.gov study NCT06888960. IPD Sharing: UNDECIDED. Countries: 1. Publications: 3.
Phenomics in Autoimmune and Inflammatory Diseases
ClinicalTrials.gov study NCT02466217. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Prospective Observational Study Evaluating the Safety and Efficacy of Immunomodulatory Therapies in Refractory Inflammatory and Autoimmune Diseases
ClinicalTrials.gov study NCT06757426. IPD Sharing: UNDECIDED. Countries: 1. Publications: 4.
Autoimmunity in Neurologic Complications of Celiac Disease
ClinicalTrials.gov study NCT00692861. IPD Sharing: Not stated. Countries: 1. Publications: 3.
Effects of Anakinra in Subjects With Corticosteroid-resistant/Intolerant Meniere's Disease and Autoimmune Inner Ear Disease
ClinicalTrials.gov study NCT03587701. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Regulation of LncRNA For Breg in Patients With Thymoma and Autoimmune Diseases
ClinicalTrials.gov study NCT02948855. IPD Sharing: YES. Countries: 1. Publications: 6.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
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DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.