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13
datasets available to search
ShareScore release 0.9.0
Dataset results
13 results for “auxotrophs”
Data from: A host-adapted auxotrophic gut symbiont induces mucosal immunodeficiency
<p>The microbiome holds great promise as a source of novel therapeutic targets for many diseases. Mining for causative microorganisms that impact processes underlying disease states should utilize Koch's postulates. Here we show a functional screen for the bacterial microbiota of intestinal immunoglobulin A (IgA)-deficient mice; we identified a novel Gram-negative bacterium, proposed to be named as <em>Tomasiella immunophila</em> that induces and degrades IgA in mouse intestine. <em>T. immunophila</em> is auxotrophic for the bacterial cell wall amino sugar N-acetylmuramic acid (MurNAc). <em>T. immunophila</em> secretes IgA-degrading enzymes into outer membrane vesicles that preferentially degrade rodent antibodies with kappa but not lambda light chains. We propose this study uncovers a new paradigm for the role of symbionts in immunodeficiency that can ultimately be applied to human disease.</p>
Dataset: 1H NMR metabolomic study of auxotrophic starvation in yeast using Multivariate Curve Resolution-Alternating Least Squares for Pathway Analysis
<p>This dataset contains the set of 1H NMR data used in https://doi.org/10.1038/srep30982.</p> <p>Yeast was grown in five different liquid media and their metabolism was characterized at 6 different time-points during 24 h.</p> <p>The media used were YSC (Yeast nitrogen base Synthetic Complete) and four Drop-Out (DM) medium that do not contain one of the following nutrients (L-histidine, L-leucine, L-methionine and uracil). Since the used yeast strain does not encode in its genome some genes relative to the biosynthesis of these four nutrients, some gene de-regulations process will occur, detectable at the metabolome level.</p> <p>In this study, we have characterized the metabolome using <sup>1</sup>H NMR spectroscopy, detecting more than 40 metabolites, and the evolution of this metabolome along the measured time-points was described by application of PCA, ASCA and MCR-ALS chemometric methods.</p>
Data from: A host-adapted auxotrophic gut symbiont induces mucosal immunodeficiency (Part I)
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A host-adapted auxotrophic gut symbiont induces mucosal immunodeficiency (Part II)
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Recombinant Human Arginase 1 (rhArg1) in Patients With Advanced Arginine Auxotrophic Solid Tumors
ClinicalTrials.gov study NCT02285101. IPD Sharing: Not stated. Countries: 1. Publications: 1.
AroA deficient Salmonella Typhimurium – More than an auxotrophic mutant
GEO Series GSE74433. Salmonella enterica subsp. enterica serovar Typhimurium. 12 samples. Type: Expression profiling by high throughput sequencing.
Microarry and RNA-seq analysis of M. tuberculosis response to threonine auxotrophic starvation
GEO Series GSE119107. Mycobacterium tuberculosis H37Rv; Mycobacterium tuberculosis. 20 samples. Type: Expression profiling by array; Expression profiling by high throughput sequencing.
XB001: Shortening of membrane lipid acyl chains compensates for phosphatidylcholine deficiency in choline‐auxotroph yeast
GEO Series GSE75725. Saccharomyces cerevisiae. 10 samples. Type: Expression profiling by array.
RNA-seq analysis of Mycobacterium tuberculosis response to threonine auxotrophic starvation
GEO Series GSE119106. Mycobacterium tuberculosis. 8 samples. Type: Expression profiling by high throughput sequencing.
Genotype specific phenotypic behaviour of auxotrophic and prototrophic gene deletion collections
GEO Series GSE89761. Saccharomyces cerevisiae. 236 samples. Type: Genome variation profiling by array.
Codon-dependent transcriptional changes in response to tryptophan limitation in the tryptophan auxotrophic pathogens Chlamydia trachomatis and Streptococcus pyogenes
GEO Series GSE174036. Streptococcus pyogenes NZ131; Homo sapiens. 48 samples. Type: Expression profiling by high throughput sequencing.
Transcriptomic response of the auxotrophic Mycobacterium avium subspecies paratuberculosis (MAP) leuD mutant under environmental stresses
GEO Series GSE36053. Mycobacterium avium subsp. paratuberculosis; Mycobacterium avium subsp. paratuberculosis K-10. 24 samples. Type: Expression profiling by array.
Transcriptome of Escherichia coli cells in coculture (Ile auxotroph and Leu auxotroph)
GEO Series GSE101471. Escherichia coli; Escherichia coli K-12. 20 samples. Type: Expression profiling by genome tiling array.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.