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49
datasets available to search
ShareScore release 0.9.0
Dataset results
49 results for “bactericidal activity”
Evaluation of Early Bactericidal Activity in Pulmonary Tuberculosis With(J-M-Pa-Z) (NC-001)
ClinicalTrials.gov study NCT01215851. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Early Bactericidal Activity of Rifampin + Meropenem + Amoxicillin/Clavulanate in Adults With Pulmonary TB
ClinicalTrials.gov study NCT03174184. IPD Sharing: NO. Countries: 1. Publications: 1.
An Early Bactericidal Activity, Safety and Tolerability of GSK3036656 in Subjects With Drug-sensitive Pulmonary Tuberculosis
ClinicalTrials.gov study NCT03557281. IPD Sharing: YES. Countries: 1. Publications: 2.
Early Bactericidal Activity of Linezolid, Gatifloxacin, Levofloxacin, Isoniazid (INH) and Moxifloxacin in HIV Negative Adults With Initial Episodes of Sputum Smear-Positive Pulmonary Tuberculosis
ClinicalTrials.gov study NCT00396084. IPD Sharing: Not stated. Countries: 2. Publications: 6.
Evaluation of Early Bactericidal Activity in Pulmonary Tuberculosis With Clofazimine (C)-TMC207 (J)-PA-824 (Pa)-Pyrazinamide (Z)
ClinicalTrials.gov study NCT01691534. IPD Sharing: Not stated. Countries: 1. Publications: 1.
A Phase 2 Study to Evaluate Early Bactericidal Activity, Safety, Tolerability, and Pharmacokinetics of Multiple Oral Doses of Telacebec (Q203)
ClinicalTrials.gov study NCT03563599. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Whole Blood Bactericidal Activity Against Mycobacterium Tuberculosis of Pyrazinamide Plus Allopurinol in Healthy Volunteers
ClinicalTrials.gov study NCT02700347. IPD Sharing: Not stated. Countries: 1. Publications: 1.
BTZ-043 - Multiple Ascending Dose (MAD) to Evaluate Safety, Tolerability and Early Bactericidal Activity (EBA)
ClinicalTrials.gov study NCT04044001. IPD Sharing: NO. Countries: 1. Publications: 1.
Evaluation of Early Bactericidal Activity and Safety in Pulmonary Tuberculosis With WX-081
ClinicalTrials.gov study NCT04608955. IPD Sharing: NO. Countries: 1. Publications: 1.
Brief Bactericidal Activity of Anti-Tuberculosis Drugs
ClinicalTrials.gov study NCT02236078. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Safety, Tolerability, Extended Early Bactericidal Activity and PK of Higher Doses Rifampicin in Adults With Pulmonary TB
ClinicalTrials.gov study NCT01392911. IPD Sharing: Not stated. Countries: 1. Publications: 3.
Evaluating the Early Bactericidal Activity, Safety and Tolerability of Nebulised RESP301 in Adults With Tuberculosis
ClinicalTrials.gov study NCT06041919. IPD Sharing: NO. Countries: 1. Publications: 0.
PNU-100480 In Newly Diagnosed, Drug Sensitive Patients With Pulmonary TB; Early Bactericidal Activity; Whole Blood Assay
ClinicalTrials.gov study NCT01225640. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Effects of Adjunct Omega-3 Long Chain Polyunsaturated Fatty Acids in Pulmonary Tuberculosis Patient: an Early Bactericidal Activity and Inflammatory Trial
ClinicalTrials.gov study NCT07118059. IPD Sharing: YES. Countries: 1. Publications: 4.
Evaluation of Early Bactericidal Activity in Pulmonary Tuberculosis (CL-010)
ClinicalTrials.gov study NCT00944021. IPD Sharing: Not stated. Countries: 0. Publications: 1.
Perioperative Immunonutrition, Phagocytic and Bactericidal Activity of Blood Platelets in Gastric Cancer Patients
ClinicalTrials.gov study NCT01704664. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Short-Course Regimen With Bedaquiline, Moxifloxacin and Pyrazinamide for Early Bactericidal Activity in Drug-Susceptible Tuberculosis
ClinicalTrials.gov study NCT07129629. IPD Sharing: YES. Countries: 0. Publications: 3.
Whole Blood Bactericidal Activity (WBA) Against Mycobacterium Tuberculosis of Faropenem Plus Amoxicillin/Clavulanic Acid in Healthy Volunteers
ClinicalTrials.gov study NCT02393586. IPD Sharing: Not stated. Countries: 1. Publications: 1.
A 14 Day Early Bactericidal Activity Study of Nitazoxanide for the Treatment of Tuberculosis
ClinicalTrials.gov study NCT02684240. IPD Sharing: YES. Countries: 1. Publications: 5.
Data from: Intestinal Serum Amyloid A suppresses systemic neutrophil activation and bactericidal activity in response to microbiota colonization
The intestinal microbiota influences the development and function of myeloid lineages such as neutrophils, but the underlying molecular mechanisms are unresolved. Using gnotobiotic zebrafish, we identified the immune effector Serum amyloid A (Saa) as one of the most highly induced transcripts in digestive tissues following microbiota colonization. Saa is a conserved secreted protein produced in the intestine and liver with described effects on neutrophils in vitro, however its in vivo functions remain poorly defined. We engineered saa mutant zebrafish to test requirements for Saa on innate immunity in vivo. Zebrafish mutant for saa displayed impaired neutrophil responses to wounding but augmented clearance of pathogenic bacteria. At baseline, saa mutants exhibited moderate neutrophilia and altered neutrophil tissue distribution. Molecular and functional analyses of isolated neutrophils revealed that Saa suppresses expression of pro-inflammatory markers and bactericidal activity. Saa's effects on neutrophils depend on microbiota colonization, suggesting this protein mediates the microbiota's effects on host innate immunity. To test tissue-specific roles of Saa on neutrophil function, we over-expressed saa in the intestine or liver and found that sufficient to partially complement neutrophil phenotypes observed in saa mutants. These results indicate Saa produced by the intestine in response to microbiota serves as a systemic signal to neutrophils to restrict aberrant activation, decreasing inflammatory tone and bacterial killing potential while simultaneously enhancing their ability to migrate to wounds.
ScienceDex guides
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.