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24 results for “barriers to adaptation”
Survey answers to identify barriers and enablers to climate change adaptation solutions (as part of the Adaptation AGORA project)
<p><span>This dataset s the result of collaborative work for Deliverable 4.1 (WP4; T4.1) of the Adaptation AGORA project. This survey aimed to capture the key factors supporting or hindering adaptation practitioners experienced with engaging citizens and stakeholders in climate change adaptation initiatives. </span></p> <p><span>The survey targeted <span>European adaptation practitioners, i.e., all professionals in charge of implementing climate change adaptation initiatives, and more particularly, those involved in collaborative processes engaging stakeholders and citizens </span><span>at the local and/or regional scale.</span></span></p> <p><span><span>The survev protocol can be found here: Euro-Mediterranean Center for Climate Change, University of Geneva, Stockholm Environment Institute, Barcelona Supercomputing Center, & Agenzia per la Promozione della Ricerca Europea. (2024). Protocol to carry out surveys to identify barriers and enablers to climate change adaptation solutions. Zenodo. <a href="https://doi.org/10.5281/zenodo.13385305" target="_blank" rel="noopener">https://doi.org/10.5281/zenodo.13385305</a></span></span></p>
Literature review of the enablers and barriers to stakeholder and citizen engagement in climate change adaptation process (as part of Adaptation AGORA project)
<p>This dataset is the result of collaborative work for Deliverable 4.1 (WP4; T4.1) of the Adaptation AGORA project. This database was used to conduct a literature review of the enablers and barriers to stakeholder and citizen engagement in climate change adaptation process. It contains 123 papers retrived from Web of Science Databse in June 2023. <span>We used a keyword search to identify and select articles that fell within the scope of our research, with each article containing at least one keyword related to climate change adaptation solutions, climate change, co-production, citizen and stakeholder involvement and factors (enablers and barriers). </span></p> <p><span>We divided the coding framework into four main sections:</span></p> <ul> <li> <p><span>Section 1 collected basic information about the paper (i.e., date, journal, authors, type of study and methods for data collection). </span></p> </li> <li> <p><span>Section 2 sought to better understand the adaptation initiatives treated in the paper. Here, we analysed 5 variables (the adaptation solutions type, sectors, benefits, scale, and location). </span></p> </li> <li> <p><span>Section 3 collected characteristics of the climate change adaptation co-production process, including the definition of co-production, the type of the co-production process, its outputs, and the methods used to engage stakeholders. </span></p> </li> <li> <p><span>Section 4 described the factors that enable or hinder the co-production process and their influence on different aspects of the process. After naming and defining each driver, we recorded the main type of factor, its impact, origin, and spatial and temporal scale of influence; the stakeholders who were responsible for and influenced by the factor, and the impacts on the various steps and outcomes of the co-production process.</span></p> <span> </span></li> </ul>
B3DB Dataset adapted for A Transparent Machine Learning Model To Understand Drugs Permeability Through the Blood Brain Barrier
<p>The B3DB dataset which we adapted for use for our paper "A Transparent Machine Learning Model To Understand Drugs Permeability Through the Blood Brain Barrier"</p>
Data from: Environmental heterogeneity and not vicariant biogeographic barriers generate community wide population structure in desert adapted snakes
Genetic structure can be influenced by local adaptation to environmental heterogeneity and biogeographic barriers, resulting in discrete population clusters. Geographic distance among populations, however, can result in continuous clines of genetic divergence that appear as structured populations. Here we evaluate the relevant importance of these three factors over a landscape characterized by environmental heterogeneity and the presence of a hypothesized biogeographic barrier in producing population genetic structure within 13 codistributed snake species using a genomic dataset. We demonstrate that geographic distance and environmental heterogeneity across western North America contribute to population genomic divergence. Surprisingly, landscape features long thought to contribute to biogeographic barriers play little role in divergence community wide. Our results suggest that isolation by environment is the most important contributor to genomic divergence. Furthermore, we show that models of population clustering that incorporate spatial information consistently outperform nonspatial models, demonstrating the importance of considering geographic distances in population clustering. We argue that environmental and geographic distances as drivers of community-wide divergence should be explored before assuming the role of biogeographic barriers.
Data from: Environmental heterogeneity and not vicariant biogeographic barriers generate community wide population structure in desert adapted snakes
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Evidence of a rapid and adaptive response of hemipteran mouthparts to a physical barrier
<p>Animals have encountered novel foods at points throughout history, due to factors such as range expansions and niche shifts driven by competition. One of the first challenges presented by novel foods is how to eat them. Mouthpart morphology is thus critical during the process of host shifts. Developmental plasticity in mouthparts is one potential mechanism that may allow animals to tolerate new foods and eventually to thrive upon them. Here, we investigated the extent to which insect mouthparts from two geographically distant populations can converge in morphology when feeding on common resources. We conducted a common garden/reciprocal transplant experiment using two populations of the cactus bug, <i>Narnia femorata</i>, that differ in mouthpart length. This insect uses straw-like mouthparts (hereafter "beak") to get through the cactus fruit wall to reach the pulp inside. Our experimental results revealed clear developmental plasticity in beak length. Insects from both populations grew longer beaks when they fed on the cactus fruit with the thicker walls, and they grew shorter beaks when they fed on the cactus fruit with the thinner walls. T<span>hus, insects from distant populations exhibited immediate developmental responses to a new food, and in the predicted directions. These results suggest that </span>some fauna may be able to respond more rapidly than predicted when they encounter novel plants.</p>
Weak coupling among barrier loci and waves of neutral and adaptive introgression across an expanding hybrid zone
<p>Hybridization can serve as an evolutionary stimulus, but we have little understanding of introgression at early stages of hybrid zone formation. We analyze reproductive isolation and introgression between a range-limited and a widespread species. Reproductive barriers are estimated based on differences in flowering time, ecogeographic distributions, and seed set from crosses. We find an asymmetrical mating barrier due to cytonuclear incompatibility that is consistent with observed clusters of coincident and concordant tension zone clines (barrier loci) for mtDNA haplotypes and nuclear SNPs. These groups of concordant clines are spread across the hybrid zone, resulting in weak coupling among barrier loci and extensive introgression. Neutral clines had nearly equal introgression into both species' ranges, while putative cases of adaptive introgression had exceptionally wide clines with centers shifted towards one species. Analyses of cline shape indicate that secondary contact was initiated within the last 800 generations with the per-generation dispersal between 200 and 400 meters, and provide some of the first estimates of the strength of selection required to account for observed levels of adaptive introgression. The weak species boundary between these species appears to be in early stages of dissolution, and ultimately will precipitate genetic swamping of the range-limited species.</p>
The Effect of Mother-Infant Contact Barrier on Maternal Sadness and Adaptation
ClinicalTrials.gov study NCT06688604. IPD Sharing: UNDECIDED. Countries: 1. Publications: 4.
Weak coupling among barrier loci and waves of neutral and adaptive introgression across an expanding hybrid zone
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Evidence of a rapid and adaptive response of hemipteran mouthparts to a physical barrier
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Reproductive barriers and genomic hotspots of adaptation during allopatric species divergence: datasets for all phylogenetic reconstructions represented in Fig 2
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Data from: Strong selection barriers explain microgeographic adaptation in wild salamander populations
Microgeographic adaptation occurs when populations evolve divergent fitness advantages across the spatial scales at which focal organisms regularly disperse. Although an increasing number of studies find evidence for microgeographic adaptation, the underlying causes often remain unknown. Adaptive divergence requires some combination of limited gene flow and strong divergent natural selection among populations. In this study, we estimated the relative influence of selection, gene flow and the spatial arrangement of populations in shaping patterns of adaptive divergence in natural populations of the spotted salamander (Ambystoma maculatum). Within the study region, A. maculatum co-occur with the predatory marbled salamander (A. opacum) in some ponds, and past studies have established a link between predation risk and adaptive trait variation in A. maculatum. Using 14 microsatellite loci, we found a significant pattern of genetic divergence among A. maculatum populations corresponding to levels of A. opacum predation risk. Additionally, A. maculatum foraging rate was strongly associated with predation risk, genetic divergence and the spatial relationship of ponds on the landscape. Our results indicate the sorting of adaptive genotypes by selection regime and strongly suggest that substantial selective barriers operate against gene flow. This outcome suggests that microgeographic adaptation in A. maculatum is possible because strong antagonistic selection quickly eliminates maladapted phenotypes despite ongoing and substantial immigration. Increasing evidence for microgeographic adaptation suggests a strong role for selective barriers in counteracting the homogenizing influence of gene flow.
Data from: Strong selection barriers explain microgeographic adaptation in wild salamander populations
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Turkish Translation of Physical Activity Barriers and Facilitators Scale; Validity, Reliability, and Cultural Adaptation
ClinicalTrials.gov study NCT05397561. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Analysis of Barriers and Facilitators to Adapted Physical Activity for Pediatric Patients With Chronic Inflammatory Bowel Diseases
ClinicalTrials.gov study NCT07383844. IPD Sharing: NO. Countries: 1. Publications: 0.
Adaptation of an Intervention Addressing Barriers to PrEP Use Among Pregnant Women in Zimbabwe
ClinicalTrials.gov study NCT06226155. IPD Sharing: YES. Countries: 1. Publications: 0.
Characterization of mouse ocular response to a 35-day spaceflight mission: Evidence of blood-retinal barrier disruption and ocular adaptations - Proteomics data
The health risks associated with spaceflight-induced ocular structural and functional damage has become a recent concern for NASA. The goal of the present study was to characterize the effects of spaceflight and reentry to 1 g on the structure and integrity of the retina and blood-retinal barrier (BRB) in the eye. To investigate possible mechanisms, changes in protein expression profiles were examined in mouse ocular tissue after spaceflight. Ten week old male C57BL/6 mice were launched to the International Space Station (ISS) on Space-X 12 at the Kennedy Space Center (KSC) on August, 2017. After a 35-day mission, mice were returned to Earth alive. Within 38 +/- 4 hours of splashdown, mice were euthanized and ocular tissues were collected for analysis. Ground control (GC) and vivarium control mice were maintained on Earth in flight hardware or normal vivarium cages respectively. Repeated intraocular pressure (IOP) measurements were performed before the flight launch and re-measured before the mice were euthanized after splashdown. IOP was significantly lower in post-flight measurements compared to that of pre-flight (14.4-19.3 mmHg vs 16.3-20.3 mmHg) (p less than 0.05) for the left eye. Flight group had significant apoptosis in the retina and retinal vascular endothelial cells compared to control groups (p less than 0.05). Immunohistochemical analysis of the retina revealed that an increased expression of aquaporin-4 (AQP-4) in the flight mice compared to controls gave strong indication of disturbance of BRB integrity. There were also a significant increase in the expression of platelet endothelial cell adhesion molecule-1 (PECAM-1) and a decrease in the expression of the BRB-related tight junction protein, Zonula occludens-1 (ZO-1). Proteomic analysis showed that many key proteins and pathways responsible for cell death, cell cycle, immune response, mitochondrial function and metabolic stress were significantly altered in the flight mice compared to ground control animals. These data indicate a complex cellular response that may alter retina structure and BRB integrity following long-term spaceflight.
Characterization of mouse ocular responses (intraocular pressure) to a 35-day (RR-9) spaceflight mission: Evidence of blood-retinal barrier disruption and ocular adaptations
The health risks associated with spaceflight-induced ocular structural and functional damage has become a recent concern for NASA. The goal of the present study was to characterize the effects of spaceflight and reentry to 1 g on the structure and integrity of the retina and blood-retinal barrier (BRB) in the eye. To investigate possible mechanisms, changes in protein expression profiles were examined in mouse ocular tissue after spaceflight. Ten week old male C57BL/6 mice were launched to the International Space Station (ISS) on Space-X 12 at the Kennedy Space Center (KSC) on August, 2017. After a 35-day mission, mice were returned to Earth alive. Within 38 +/− 4 hours of splashdown, mice were euthanized and ocular tissues were collected for analysis. Ground control (GC) and vivarium control mice were maintained on Earth in flight hardware or normal vivarium cages respectively. Repeated intraocular pressure (IOP) measurements were performed before the flight launch and remeasured before the mice were euthanized after splashdown. IOP was significantly lower in post-flight measurements compared to that of pre-flight (14.4–19.3 mmHg vs 16.3–20.3 mmHg) (p less than 0.05) for the left eye. Flight group had significant apoptosis in the retina and retinal vascular endothelial cells compared to control groups (p less than 0.05). Immunohistochemical analysis of the retina revealed that an increased expression of aquaporin-4 (AQP-4) in the flight mice compared to controls gave strong indication of disturbance of BRB integrity. There were also a significant increase in the expression of platelet endothelial cell adhesion molecule-1 (PECAM-1) and a decrease in the expression of the BRB related tight junction protein, Zonula occludens-1 (ZO-1). Proteomic analysis showed that many key proteins and pathways responsible for cell death, cell cycle, immune response, mitochondrial function and metabolic stress were significantly altered in the flight mice compared to ground control animals. These data indicate a complex cellular response that may alter retina structure and BRB integrity following long-term spaceflight. This dataset derives results from the intraocular pressure (tonometry) assay.
Characterization of mouse ocular responses (Microscopy) to a 35-day (RR-9) spaceflight mission: Evidence of blood-retinal barrier disruption and ocular adaptations
The health risks associated with spaceflight-induced ocular structural and functional damage has become a recent concern for NASA. The goal of the present study was to characterize the effects of spaceflight and reentry to 1 g on the structure and integrity of the retina and blood-retinal barrier (BRB) in the eye. To investigate possible mechanisms, changes in protein expression profiles were examined in mouse ocular tissue after spaceflight. Ten week old male C57BL/6 mice were launched to the International Space Station (ISS) on Space-X 12 at the Kennedy Space Center (KSC) on August, 2017. After a 35-day mission, mice were returned to Earth alive. Within 38 +/− 4 hours of splashdown, mice were euthanized and ocular tissues were collected for analysis. Ground control (GC) and vivarium control mice were maintained on Earth in flight hardware or normal vivarium cages respectively. Repeated intraocular pressure (IOP) measurements were performed before the flight launch and re-measured before the mice were euthanized after splashdown. IOP was significantly lower in post-flight measurements compared to that of pre-flight (14.4–19.3 mmHg vs 16.3–20.3 mmHg) (p less than 0.05) for the left eye. Flight group had significant apoptosis in the retina and retinal vascular endothelial cells compared to control groups (p less than 0.05). Immunohistochemical analysis of the retina revealed that an increased expression of aquaporin-4 (AQP-4) in the flight mice compared to controls gave strong indication of disturbance of BRB integrity. There were also a significant increase in the expression of platelet endothelial cell adhesion molecule-1 (PECAM-1) and a decrease in the expression of the BRB-related tight junction protein, Zonula occludens-1 (ZO-1). Proteomic analysis showed that many key proteins and pathways responsible for cell death, cell cycle, immune response, mitochondrial function and metabolic stress were significantly altered in the flight mice compared to ground control animals. These data indicate a complex cellular response that may alter retina structure and BRB integrity following long-term spaceflight. This dataset derives results from Molecular Cellular Imaging (Microscopy) assay.
Adaptive immunity to retroelements promotes barrier integrity [bulk_DC_KC_LC]
GEO Series GSE266531. Mus musculus. 30 samples. Type: Expression profiling by high throughput sequencing.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.