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66 results for “basal ganglia”
Full summary statistics of mixQTL for GTEx v8 Brain_Putamen_basal_ganglia
The mixQTL method is described in paper doi.org/10.1101/2020.04.22.050666. Please cite the original paper if using the data.
Full summary statistics of mixQTL for GTEx v8 Brain_Caudate_basal_ganglia
The mixQTL method is described in paper doi.org/10.1101/2020.04.22.050666. Please cite the original paper if using the data.
Organization of reward and movement signals in the basal ganglia and cerebellum
<p>The basal ganglia and the cerebellum are major subcortical structures in the motor system. The basal ganglia have been cast as the reward center of the motor system, whereas the cerebellum is thought to be involved in adjusting sensorimotor parameters. Recent findings of reward signals in the cerebellum have challenged this dichotomous view. To compare the basal ganglia and the cerebellum directly, we recorded from oculomotor regions in both structures from the same monkeys. We partitioned the trial-by-trial variability of the neurons into reward and eye-movement signals to compare the coding across structures. Reward expectation and movement signals were the most pronounced in the output structure of the basal ganglia, intermediate in the cerebellum, and the smallest in the input structure of the basal ganglia. These findings suggest that reward and movement information is sharpened through the basal ganglia, resulting in a higher signal-to-noise ratio than in the cerebellum.</p>
Basal Ganglia Neurons in Healthy and Parkinsonian Primates Generate Recurring Sequences of Spikes
<p>These data are the source data for the manuscript entitled "Basal Ganglia Neurons in Healthy<br> and Parkinsonian Primates Generate Recurring Sequences of Spikes", authored by Adriana Galvan<br> and Thomas Wichmann (Emory University, Atlanta, GA). </p> <p>The data are interspike interval measurements generated from electrophysiological recordings<br> of spontaneous spiking activities of single neurons in the basal ganglia of awake monkeys, before<br> and after rendering them parkinsonian by treatment with MPTP. THe animals were not engaged in any<br> task or other structured activity.</p> <p>The data format is a one-column listing of successive interspike intervals, and are presented in<br> milliseconds. The data are structured into different folders:</p> <p>GPe normal - data collected in the external pallidal segment, under normal conditions<br> GPe MPTP - data collected in the external pallidal segment, under parkinsonian conditions<br> STN normal - data collected in the subthalamic nucleus, under normal conditions<br> STN MPTP - data collected in the subthalamic nucleus, under parkinsonian conditions<br> GPi normal - data collected in the internal pallidal segment, under normal conditions<br> GPi MPTP - data collected in the internal pallidal segment, under parkinsonian conditions</p> <p>A 'Read Me' file is included, containing these explanations.</p> <p>For questions, please contact the corresponding author, Dr. Thomas Wichmann (twichma@emory.edu).</p> <p> </p>
Optogenetic activation of striatal D1R and D2R cells differentially engages downstream connected areas beyond the basal ganglia
<p>This dataset supports the Cell Reports publication entitled '<em>Optogenetic activation of striatal D1/D2 medium spiny neurons differentially engages downstream connected areas beyond the basal ganglia</em>' (https://doi.org/10.1016/j.celrep.2021.110161). Please refer to this publication for detailed information. </p> <p>The dataset contains functional (GE-BOLD) and anatomical (T1-weighted) scans of a total of 34 subjects (Cre-mouse lines Drd1-Cre, Drd2-Cre, A2A-Cre, and wildtype mice) in NIFTI format, multiplied by 10. The 'StimulationProtocol' text file specifies the precise onset (in seconds) and duration (in seconds) of the optogenetic stimulation during a 480 seconds functional scan. The 'SubjectDetails' file lists the subject IDs, their gender, their genotype, the number of functional scans, and whether they have an associated anatomical scan.</p>
Activation and connectivity maps - A chronometric relationship between circuits underlying learning and error monitoring in the basal ganglia and salience network
<p>Activation and connectivity maps of the study "A chronometric relationship between circuits underlying learning and error monitoring in the basal ganglia and salience network".</p> <ul> <li>Error-correct.nii corresponds to the statistical map of group-level differences in BOLD signal between correct and erroneous responses shown in figure 4;</li> <li>Late-initial.nii corresponds to the statistical map of group-level differences in BOLD signal between the initial and late learning periods shown in figure 5;</li> <li>Conn_error-correct_dACC.nii corresponds to the results from the seed-to-voxel gPPI analysis, using the dACC as seed region, showing areas of higher functional connectivity in erroneous compared to correct responses, shown in figure 8.</li> </ul>
Dataset from Maith, O., Baladron, J., Einhäuser, W., & Hamker, F. H. (2023). Exploration behavior after reversals is predicted by STN-GPe synaptic plasticity in a basal ganglia model. Submitted to iScience.
<p>This dataset contains all analyzed data from the study "Maith, O., Baladron, J., Einhäuser, W., & Hamker, F. H. (2023). Exploration behavior after reversals is predicted by STN-GPe synaptic plasticity in a basal ganglia model. Submitted to iScience.". It includes the behavioral data of 20 human participants (folder "psychExp") and of simulations of a neuro-computational basal ganglia model (folder "simulations") of the study.</p> <p>To replicate the results of the study, the dataset can be analyzed using the code provided separately under the following identifier: https://doi.org/10.5281/zenodo.6555886. The dataset is organized in the directory structure required for this purpose.</p> <p>For the human participants, only preprocessed eye-tracking and general behavioral data (.mat files) and the final analyzed behavioral data (output files) generated with the script "get_vps_outputs.m" (folder psychExp/..../3_srcAna/) are available. For more information about preprocessing steps as well as raw data of the eye-tracking experiment, please contact us by email (click <a href="https://www.tu-chemnitz.de/urz/mail/adrx.html?1-d29sZmdhbmcuZWluaGFldXNlci10cmV5ZXJAcGh5c2lrLg==">here</a>).</p>
The indirect pathway of the basal ganglia promotes transient punishment, but not motor suppression
<p>Data and code for manuscript entitled "The indirect pathway of the basal ganglia promotes transient punishment, but not motor suppression"</p>
Organization of reward and movement signals in the basal ganglia and cerebellum
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Data from: Inhibitory basal ganglia nuclei differentially innervate pedunculopontine nucleus subpopulations and evoke opposite motor and valence behaviors
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Neural activity during a simple reaching task in macaques is counter to gating and rebound in basal ganglia-thalamic communication
<div class="page"> <div class="layoutArea"> <div class="column"> <p>Task-related activity in the ventral thalamus, a major target of basal ganglia output, is often assumed to be permitted or triggered by changes in basal ganglia activity through gating- or rebound-like mechanisms. To test those hypotheses, we sampled single-unit activity from connected basal ganglia output and thalamic nuclei (globus pallidus-internus, GPi, and ventrolateral-anterior nucleus, VLa) in monkeys performing a reaching task. Rate increases were the most common peri-movement change in both nuclei. Moreover, peri-movement changes generally began earlier in VLa than in GPi. Simultaneously-recorded GPi-VLa pairs rarely showed short-timescale spike-to-spike correlations or slow across-trials covariations and both were equally positive and negative. Finally, spontaneous GPi bursts and pauses were both followed by small, slow reductions in VLa rate. These results appear incompatible with standard gating and rebound models. Still, gating or rebound may be possible in other physiological situations: Simulations show how GPi-VLa communication can scale with GPi synchrony and GPi-to-VLa convergence, illuminating how synchrony of basal ganglia output during motor learning or in pathological conditions may render this pathway effective. Thus, in the healthy state, basal ganglia-thalamic communication during learned movement is more subtle than expected, with changes in firing rates possibly being dominated by a common external source.</p> </div> </div> </div>
vanBeest iScience 2024: The direct and indirect pathways of the basal ganglia antagonistically influence cortical activity and perceptual decisions.
<p>Data for the paper 'The direct and indirect pathways of the basal ganglia antagonistically influence cortical activity and perceptual decisions.' by van Beest et al. 2024, iScience: https://doi.org/10.1016/j.isci.2024.110753</p> <p>Code to analyze data is available via https://github.com/EnnyvanBeest/vanBeest_iScience2024.</p> <p> </p> <p> </p>
Multimodal Investigation of Cortico-Basal Ganglia-Thalamo-Cortical Network Dynamics in Dystonic Patients with Deep Brain Stimulation
ClinicalTrials.gov study NCT06716983. IPD Sharing: Not stated. Countries: 1. Publications: 13.
Evaluation of Dysfunction of the Basal Ganglia Before a Parkinsonian Walking in the Elderly: Risk of Falling and Confusional State
ClinicalTrials.gov study NCT02885493. IPD Sharing: NO. Countries: 1. Publications: 2.
Treating Sleep/Wake Cycle Disturbances in Basal Ganglia Disorders With Ramelteon
ClinicalTrials.gov study NCT00907595. IPD Sharing: Not stated. Countries: 1. Publications: 3.
Neural activity during a simple reaching task in macaques is counter to gating and rebound in basal ganglia-thalamic communication
Open the record for dataset details and reuse information.
Full summary statistics of mixQTL for GTEx v8 Brain_Nucleus_accumbens_basal_ganglia
The mixQTL method is described in paper doi.org/10.1101/2020.04.22.050666. Please cite the original paper if using the data.
Human brain basal ganglia
SciDraw upload
Genetically distinct parallel pathways in the entopeduncular nucleus for limbic and sensorimotor output of the basal ganglia
GEO Series GSE95133. Mus musculus. 3 samples. Type: Expression profiling by high throughput sequencing.
Functional Identification of Specialized Basal Ganglia Circuits that Regulate Vocal Motor Sequences
GEO Series GSE136086. Taeniopygia guttata. 2 samples. Type: Expression profiling by high throughput sequencing.
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.