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16 results for “beta-hydroxybutyrate”
Beta-hydroxybutyrate ketone concentrations via ketometer and colorimetric assay in Steller sea lion whole blood and plasma
<p>We evaluated the Precision Xtra™ ketometer during a larger study categorizing free-ranging Steller sea lion (<em>Eumetopias jubatus</em>; SSL) pup fasting status, necessitating identification of plasma β-hydroxybutyrate concentrations ([β-HBA]) around a < and ≥0.3 mmol/L threshold. Whole blood samples mixed with sodium heparin (NaHep) or ethylenediaminetetraacetic acid liquid anticoagulants were tested <10 minutes after collection (n=14; triplicate technical replicates). Plasma (stored at -80°C, NaHep, <em>Thaw1</em>) measured via our laboratory's <em>Reference Assay </em>(Sigma Aldrich, St. Louis, MO, Kit #MAK041) served as the standard [β-HBA] for ketometer comparisons. Our observed β-HBA range (0.0–1.6 mmol/L), consistent with published [β-HBA] of free-ranging Otariid pups, represented the lower 20% of the ketometer's range (0.0–8.0 mmol/L). The maximal coefficient of variation (%CV) of ketometer technical replicates was 9.1% (NaHep, whole blood). The majority of ketometer technical replicate sets (84%, including all matrices, anticoagulants, and thawings) were identical (CV=0%). We found linear relationships and agreement of ketometer [β-HBA] between whole blood preserved with different anticoagulants and between whole blood and plasma (<em>Thaw1</em>) measurements. The ketometer produced results with linearity to the <em>Reference Assay</em> for both whole blood and plasma (<em>Thaw1</em>). We identified a non-linear relationship between plasma at <em>Thaw1</em> and <em>Thaw2</em> (tested four months apart, NaHep), as only samples with higher SSL [B-HBA] decreased in concentration, and all others remained the same. With respect to categorizing SSL pup fasting, the ketometer % Accuracy, %Sensitivity, and %Specificity for samples with <em>Reference Assay</em> β-HBA <0.2 and >0.4 mmol/L were 100%. We adopted a modified procedure: plasma samples with mean ketometer concentrations ±0.1 mmol/L of 0.3 mmol/L β-HBA were re-evaluated using the <em>Reference Assay</em>, improving measurement precision from tenths (ketometer) to thousandths (assay) mmol/L. The Precision Xtra™ ketometer was valuable to our application, over the range of [β-HBA] observed in SSL pup plasma and whole blood samples.</p>
Beta-hydroxybutyrate ketone concentrations via ketometer and colorimetric assay in Steller sea lion whole blood and plasma
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Evaluation of the Safety and Tolerability of Exogenous Ketosis Induced by Free Beta-hydroxybutyrate.
ClinicalTrials.gov study NCT05584371. IPD Sharing: YES. Countries: 1. Publications: 8.
RNA-sequencing reveals niche gene expression effects of beta-hydroxybutyrate in primary myotubes
GEO Series GSE179023. Mus musculus. 36 samples. Type: Expression profiling by high throughput sequencing.
Beta-hydroxybutyrate alters bovine preimplantation embryo development through transcriptional and epigenetic mechanisms.
GEO Series GSE271458. Bos taurus. 6 samples. Type: Expression profiling by high throughput sequencing.
Transcriptome changes in MCF-7 and T47D breast cancer cells after four day incubation in glucose deprived medium and beta-hydroxybutyrate
GEO Series GSE153830. Homo sapiens. 15 samples. Type: Expression profiling by high throughput sequencing.
Subcutaneous Aspart Insulin to Treat Diabetic Ketoacidosis (DKA) and Beta-Hydroxybutyrate Testing in DKA
ClinicalTrials.gov study NCT00920725. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Beta-Hydroxybutyrate Feasibility Treating IBD
ClinicalTrials.gov study NCT06351124. IPD Sharing: NO. Countries: 1. Publications: 0.
Comparison Between Breath Acetone and Blood Beta-Hydroxybutyrate
ClinicalTrials.gov study NCT03299543. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Suppression of colorectal cancer by ketogenic diet and beta-hydroxybutyrate
GEO Series GSE196965. Homo sapiens. 11 samples. Type: Expression profiling by high throughput sequencing.
Beta-Hydroxybutyrate but not NMN supplementation mimics caloric restriction reducing early mortality in Daphnia
GEO Series GSE292526. Daphnia magna. 22 samples. Type: Expression profiling by high throughput sequencing.
Embryonic response to high beta-hydroxybutyrate (BHB) levels in postpartum dairy cows [methylation]
GEO Series GSE122645. Bos taurus. 4 samples. Type: Methylation profiling by array.
Embryonic response to high beta-hydroxybutyrate (BHB) levels in postpartum dairy cows [gene expression]
GEO Series GSE122601. Bos taurus. 4 samples. Type: Expression profiling by array.
Embryonic response to high beta-hydroxybutyrate (BHB) levels in postpartum dairy cows
GEO Series GSE122646. Bos taurus. 8 samples. Type: Expression profiling by array; Methylation profiling by array.
Effect of Beta-Hydroxybutyrate on Gene Expression in Immunotherapy and Castration Resistant Prostate Cancer Cells
GEO Series GSE206297. Mus musculus. 4 samples. Type: Expression profiling by high throughput sequencing.
Single-cell RNA sequencing of circulating 41BBzeta CART19 cells in mice treated with gavage of water or beta-hydroxybutyrate
GEO Series GSE310783. Homo sapiens. 2 samples. Type: Expression profiling by high throughput sequencing.
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