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190 results for “bicarbonate”
Supporting data files for "Binding Sites of Bicarbonate in PEP Carboxylase"
<p>The files in this archive are the supporting data for the article "Binding Sites of Bicarbonate in PEP Carboxylase". The article contains all scripts and input files used to perform and analyse the simulations.</p>
Data from: Redox state of NAD modulates the activation of Na-bicarbonate cotransporter NBCe1-B by IRBIT and L-IRBIT
<p>NAD is known as a coenzyme for many enzymes catalyzing redox reactions or as a substrate for enzymes for second messenger cADP-ribose generation or protein deacetylation. IRBIT and L-IRBIT are structurally conserved with dehydrogenases but lacking catalytic activity. By protein interaction, the IRBITs instead modulate many proteins of fundamental biological importance. Among these is the Na+-HCO3− cotransporter NBCe1-B, which plays a central role in intracellular pH (pHi) regulation and epithelial electrolyte transport. Here, we demonstrate that NAD modulates NBCe1-B activation by serving as a cofactor of the IRBITs. Blocking NAD salvage pathway decreases NBCe1-B activation by the IRBITs. NAD+ administration enhances, whereas NADH decreases NBCe1-B activity. Our study reveals a new role of NAD and greatly expands our appreciation of NAD biology. Because NAD redox state fluctuates greatly with metabolic status, our work provides insight into how, via IRBITs, energy metabolism could affect pHi regulation and many other IRBIT-dependent processes.</p>
Study of the Effect of SZC on Serum Potassium and Serum Bicarbonate in Patients With Hyperkalemia and Metabolic Acidosis Associated With Chronic Kidney Disease
ClinicalTrials.gov study NCT04727528. IPD Sharing: Not stated. Countries: 2. Publications: 1.
Sodium Bicarbonate Supplementation in Chronic Kidney Disease Evaluation of Dose Response, Safety and Beneficial Effects
ClinicalTrials.gov study NCT00888290. IPD Sharing: NO. Countries: 1. Publications: 2.
The Effect of Bicarbonate Supplementation on Performance and Gastrointestinal Symptoms in Rugby Players.
ClinicalTrials.gov study NCT07017582. IPD Sharing: NO. Countries: 1. Publications: 0.
Bicarbonate Administration and Cognitive Function in Midlife and Older Adults With CKD
ClinicalTrials.gov study NCT04600323. IPD Sharing: YES. Countries: 1. Publications: 2.
To Evaluate Efficacy and Tolerability of Sodium Bicarbonate Toothpaste and Its Effect on Opportunistic or Resistant Organisms
ClinicalTrials.gov study NCT02207400. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Effects of β-alanine and Sodium Bicarbonate Supplementation on Physical Capacity and Biochemical Markers Concentrations
ClinicalTrials.gov study NCT07092930. IPD Sharing: YES. Countries: 1. Publications: 2.
A Proof-of-principle Clinical Study Investigating the Efficacy of an Experimental Dentifrice Containing Sodium Bicarbonate and Sodium Hyaluronate on Gingivitis
ClinicalTrials.gov study NCT04737538. IPD Sharing: YES. Countries: 1. Publications: 1.
Sodium Bicarbonate for the Treatment of Severe Metabolic Acidosis With Moderate or Severe Acute Kidney Injury in ICU
ClinicalTrials.gov study NCT04010630. IPD Sharing: YES. Countries: 1. Publications: 2.
Bicarbonate for Tumor Related Pain
ClinicalTrials.gov study NCT01350583. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Effect of Potassium Bicarbonate Supplementation on Bone and Muscle in Older Adults
ClinicalTrials.gov study NCT00357214. IPD Sharing: Not stated. Countries: 1. Publications: 3.
Bicarbonate Administration in CKD
ClinicalTrials.gov study NCT02915601. IPD Sharing: YES. Countries: 1. Publications: 3.
Musculoskeletal Effects of Bicarbonate
ClinicalTrials.gov study NCT01475214. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Investigations of the Optimum Serum Bicarbonate Level in Renal Disease.
ClinicalTrials.gov study NCT01574157. IPD Sharing: NO. Countries: 1. Publications: 1.
The BASE Study: Bicarbonate Administration to Stabilize Estimated Glomerular Filtration Rate (eGFR)
ClinicalTrials.gov study NCT02521181. IPD Sharing: Not stated. Countries: 1. Publications: 1.
An Efficacy Study of Stain Control of a 67% Sodium Bicarbonate Containing Toothpaste on Chlorhexidine Tooth Staining
ClinicalTrials.gov study NCT01962493. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Data from: Redox state of NAD modulates the activation of Na-bicarbonate cotransporter NBCe1-B by IRBIT and L-IRBIT
Open the record for dataset details and reuse information.
Cellular bicarbonate accumulation and vesicular proton transport promote calcification in the sea urchin larva
The sea urchin embryo develops a calcitic endoskeleton through intracellular formation of amorphous calcium carbonate (ACC). Intracellular precipitation of ACC, requires HCO3-/CO32- concentrating as well as proton export mechanisms to promote calcification. These processes are of fundamental importance in biological mineralization, but remain largely unexplored. Here we demonstrate that the calcifying primary mesenchyme cells (PMCs) utilize Na+/H+- exchange (NHE) mechanisms to control cellular pH homeostasis during maintenance of the skeleton. During skeleton re-calcification, pHi of PMCs is increased accompanied by substantial elevations in intracellular [HCO3-] mediated by the Na+/HCO3-cotransporter Sp-Slc4a10. However, PMCs lower their pHi regulatory capacities associated with a reduction in NHE activity. Live-cell imaging using GFP reporter constructs in combination with intra-vesicular pH measurements demonstrated alkaline and acidic populations of vesicles in PMCs and extensive trafficking of large V-type H+-ATPase (VHA)-rich acidic vesicles in blastocoelar filopodial cells (BFCs). Pharmacological and gene expression analyses underline a central role of the VHA isoforms Sp-ATP6V0a1, Sp-ATP6V01_1 and Sp-ATPa1-4 for the process of skeleton re-calcification. These results highlight novel pH regulatory strategies in calcifying cells of a marine species with important implications for our understanding of the mineralization process in times of rapid changes in oceanic pH.
Effects of Oral Sodium Bicarbonate Supplementation in Haemodialysis Patients (BicHD)
ClinicalTrials.gov study NCT02692378. IPD Sharing: NO. Countries: 1. Publications: 10.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
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DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.