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194 results for “bone infection”
Fluorescence labelled infected mouse bone tissues
<p>This dataset comprises fluorescence-labeled images of infected mouse bone tissues obtained through a multiphoton confocal laser scanning microscope (LSM 780 META, Carl Zeiss, Jena, Germany). These images are stored in the CZI native file format and are provided for publication purposes. To know more about the images please refer to this <a href="https://doi.org/10.3390/ijms24119762">article</a>. If you find these images valuable, kindly acknowledge this dataset and the associated article: </p> <p>Mandal, S.; Tannert, A.; Ebert, C.; Guliev, R.R.; Ozegowski, Y.; Carvalho, L.;Wildemann, B.; Eiserloh, S.; Coldewey, S.M.; Löffler, B.; Bastiao Silva, L.; Hoerr, V.; Tuchscherr, L.; Neugebauer, U.: Insights into <em>S. aureus</em>-induced bone deformation in a mouse model of chronic osteomyelitis using fluorescence and Raman imaging. Int. J. Mol. Sci. 2023, 24, 9762. https://doi.org/10.3390/ijms24119762</p>
IFN-γ primes bone marrow neutrophils to acquire regulatory functions in severe viral respiratory infections
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The bone marrow endothelial progenitor cell response to septic infection: Dataset
<p>An early increase in the level of endothelial progenitor cells (EPCs) in the systemic circulation occurs in patients with septic infection/sepsis. The significance and underlying mechanisms of this response remain unclear. This study investigated the bone marrow EPC response in adult mice with septic infection induced by intravenous injection (i.v.) of <em>Escherichia coli</em>. For <em>in vitro</em> experiments, sorted marrow stem/progenitor cells (SPCs) including lineage(lin)<sup>-</sup>stem cell growth factor receptor(c-kit)<sup>+</sup>stem cell antigen-1(Sca-1)<sup>-</sup>, lin<sup>-</sup>c-kit<sup>+</sup>, and lin<sup>-</sup> cells were cultured with or without lipopolysaccharides (LPS) and recombinant murine vascular endothelial growth factor (VEGF) in the absence and presence of anti-Sca-1 crosslinking antibodies. In a separate set of experiments, marrow lin<sup>-</sup>c-kit<sup>+</sup> cells from green fluorescence protein (GFP)<sup>+</sup> mice, i.v. challenged with heat-inactivated <em>E. coli</em> or saline for 24 h were subcutaneously implanted in Matrigel plugs for 5 weeks. Marrow lin<sup>-</sup>c-kit<sup>+</sup> cells from Sca-1 knockout (KO) mice challenged with heat-inactivated <em>E. coli</em> for 24 h were cultured in the Matrigel medium for 8 weeks. The marrow pool of EPCs bearing the lin<sup>-</sup>c-kit<sup>+</sup>Sca-1<sup>+</sup>VEGF receptor 2 (VEGFR2)<sup>+</sup> (LKS VEGFR2<sup>+</sup>) and LKS CD133<sup>+</sup>VEGFR2<sup>+</sup> surface markers expanded rapidly following septic infection, which was supported by both proliferative activation and phenotypic conversion of marrow stem/progenitor cells. An increase in marrow EPCs and their reprogramming for enhancing angiogenic activity correlated with cell-marked upregulation of Sca-1 expression. Sca-1 coupled with ras-related C3 botulinum toxin substrate 2 (Rac2) in signaling the marrow EPC response. Septic infection caused a substantial increase in plasma levels of IFN-γ, VEGF, G-CSF, and SDF-1. The early increase in circulating EPCs was accompanied by their active homing and incorporation into pulmonary microvasculature. These results demonstrate that the marrow EPC response is a critical component of the host defense system. Sca-1 signaling plays a pivotal role in the regulation of EPC response in mice with septic infection.</p>
Bone Health in Aging HIV Infected Women
ClinicalTrials.gov study NCT02815566. IPD Sharing: YES. Countries: 2. Publications: 1.
Bone Mineral Density in Human Immunodeficiency Virus Type 1 (HIV-1)-Infected Adult Subjects Switching From a Tenofovir Regimen to a Dolutegravir Plus Rilpivirine Regimen
ClinicalTrials.gov study NCT02478632. IPD Sharing: YES. Countries: 6. Publications: 1.
Safety and Effectiveness of Alendronate for Bone Mineral Density in HIV-infected Children and Adolescents
ClinicalTrials.gov study NCT00921557. IPD Sharing: NO. Countries: 3. Publications: 4.
The bone marrow endothelial progenitor cell response to septic infection: Dataset
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Persistent Bone Marrow Hemozoin Accumulation Confers Survival Advantage Against Bacterial Infection via Myd88-Cell Intrinsic Signaling
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Calcium and High-dose Vitamin D Supplementation on Bone Mineral Density Among HIV-infected Children and Adolescents
ClinicalTrials.gov study NCT02426840. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Initial Oral Antibiotics for Bone and Joint Infections in Children
ClinicalTrials.gov study NCT06827496. IPD Sharing: UNDECIDED. Countries: 1. Publications: 1.
Hardware Preservation in Management of Infected Non United or Delayed United Fractures of Long or Short Bones by Debridement and Local Calcium Sulfate Loaded by Antibiotics
ClinicalTrials.gov study NCT05231148. IPD Sharing: YES. Countries: 1. Publications: 3.
Vancomycin Powder Combined With Autogenous Bone Graft as a Prevention for Post-operative Infection for Spine Surgery
ClinicalTrials.gov study NCT03883022. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Subcutaneous Suppressive Antibiotic Therapy for Bone and Joint Infections
ClinicalTrials.gov study NCT03403608. IPD Sharing: NO. Countries: 1. Publications: 1.
Antibiotic Loaded Bone Cement in Prevention of Periprosthetic Joint Infections in Primary Total Knee Arthroplasty
ClinicalTrials.gov study NCT04135170. IPD Sharing: NO. Countries: 1. Publications: 1.
Multicentre Study To Assess Changes In Bone Mineral Density Of The Switch From Tenofovir To Abacavir In Hiv-1-Infected Subjects With Loss Of Bone Mineral Density
ClinicalTrials.gov study NCT01153217. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Regional Bone Turnover Using 18F-fluoride-PET/CT in HIV-1-infected Men: PETRAM Study
ClinicalTrials.gov study NCT03405012. IPD Sharing: NO. Countries: 1. Publications: 4.
The Effect of Alendronate, Calcium, and Vitamin D on Bone Mineral Density in HIV Infected Patients
ClinicalTrials.gov study NCT00061256. IPD Sharing: Not stated. Countries: 1. Publications: 6.
Long-Term Oral Acyclovir Usage to Prevent Herpes Zoster Virus Infection After Bone Marrow Transplant
ClinicalTrials.gov study NCT00209352. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Cutibacterium Acnes in Bone and Joint Infections
ClinicalTrials.gov study NCT03950063. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Prevention of RSV Infections in Bone Marrow Transplant Recipients
ClinicalTrials.gov study NCT00001903. IPD Sharing: Not stated. Countries: 1. Publications: 3.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.