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46 results for “bone resorption”
Sclerostin blockade inhibits bone resorption through PDGF receptor signaling in osteoblast lineage cells
<p>While sclerostin-neutralizing antibodies (Scl-Ab) transiently stimulate bone formation by activating Wnt signaling in osteoblast lineage cells, they exert sustained inhibition of bone resorption, suggesting an alternate signaling pathway by which Scl-Ab control osteoclast activity. Since sclerostin can activate platelet-derived growth factor receptors (PDGFRs) in osteoblast lineage cells in vitro and PDGFR signaling in these cells induces bone resorption through M-CSF secretion, we hypothesized that the prolonged anti-catabolic effect of Scl-Ab could result from PDGFR inhibition. We show here that inhibition of PDGFR signaling in osteoblast lineage cells is sufficient and necessary to mediate prolonged Scl-Ab effect on M-CSF secretion and osteoclast activity in mice. Indeed, sclerostin co-activates PDGFRs independently of Wnt/β-catenin signaling inhibition, by forming a ternary complex with LRP6 and PDGFRs in pre-osteoblasts. In turn, Scl-Ab prevents sclerostin-mediated co-activation of PDGFR signaling and consequent M-CSF up-regulation in pre-osteoblast cultures, thereby inhibiting osteoclast activity in pre-osteoblast/osteoclast co-culture assays. These results provide a new potential mechanism explaining the dissociation between anabolic and anti-resorptive effects of long-term Scl-Ab.</p>
Early Effects of Abaloparatide on Tissue-Based Indices of Bone Formation and Resorption
ClinicalTrials.gov study NCT03710889. IPD Sharing: NO. Countries: 1. Publications: 3.
Acute Effect of Teriparatide With Bisphosphonate or Denosumab on Bone Resorption
ClinicalTrials.gov study NCT01750086. IPD Sharing: Not stated. Countries: 1. Publications: 6.
Irisin directly stimulates osteoclastogenesis and bone resorption in vitro and in vivo: RNAseq dataset
Irisin, a skeletal-muscle secreted myokine, facilitates muscle-bone crosstalk and skeletal remodeling in part by its action on osteoblasts and osteocytes. In this study, we investigated whether irisin directly regulates osteoclasts. In vitro, irisin (2–10 ng/mL) increased osteoclast differentiation in C57BL/6J mouse bone marrow progenitors; however, this increase was blocked by a neutralizing antibody to integrin αVβ5. Irisin also increased bone resorption on several substrates in situ. RNAseq revealed differential gene expression induced by irisin including upregulation of markers for osteoclast differentiation and resorption, as well as osteoblast-stimulating 'clastokines'. Forced expression of the irisin precursor Fndc5 in transgenic C57BL/6J mice resulted in lower bone mass at three ages and greater in vitro osteoclastogenesis from Fndc5-transgenic bone marrow progenitors. This study demonstrates that irisin acts directly on osteoclast progenitors to increase differentiation and promote bone resorption, supporting the tenet that irisin not only stimulates bone remodeling but may also be an important counter-regulatory hormone.
Hypercalciuria in postmenopausal women with reduced bone mineral density is associated with different mineral metabolic profiles: effects of treatment with thiazides and anti-resorptives
<pre>Hypercalciuria in postmenopausal women with reduced bone mineral density is associated with different mineral metabolic profiles: effects of treatment with thiazides and anti-resorptives</pre>
Soft Tissue Width and Abutment Height Influence Peri-implant Bone Resorption
ClinicalTrials.gov study NCT03229005. IPD Sharing: NO. Countries: 1. Publications: 2.
Comparing Labial and Lingual Orthodontic Appliances on Root Resorption and Bone Height
ClinicalTrials.gov study NCT06401369. IPD Sharing: NO. Countries: 1. Publications: 6.
Using Platelet Rich Plasma in Reducing Alveolar Bone Resorption During Rapid Maxillary Expansion
ClinicalTrials.gov study NCT03028038. IPD Sharing: NO. Countries: 1. Publications: 11.
Optimal Meals to Reduce Bone Resorption in Women With Osteopenia
ClinicalTrials.gov study NCT07056322. IPD Sharing: UNDECIDED. Countries: 1. Publications: 19.
Root Resorption and Alveolar Bone in the Maxillary Canine Retraction Using Injectable Platelet-rich Fibrin: A Split-Mouth Trial
ClinicalTrials.gov study NCT06634888. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Innervation of Vascularized Iliac Transplant Avoids Resorption in Jaw Bone Reconstruction
ClinicalTrials.gov study NCT03889587. IPD Sharing: NO. Countries: 1. Publications: 1.
The Use of a Porcine Collagen Matrix for the Prevention of Buccal Bone Wall Resorption During Implant Placement in the Aesthetic Zone.
ClinicalTrials.gov study NCT06622759. IPD Sharing: NO. Countries: 1. Publications: 11.
Buccal Bone Resorption in Immediate SLActive Implant Placement Thin vs. Thick Buccal Bone
ClinicalTrials.gov study NCT04731545. IPD Sharing: UNDECIDED. Countries: 1. Publications: 1.
Buccal Bone Resorption in Immediate Implants in Thin and Thick Buccal Plates of Bone in Esthetic Zone
ClinicalTrials.gov study NCT04630665. IPD Sharing: YES. Countries: 1. Publications: 2.
Irisin directly stimulates osteoclastogenesis and bone resorption in vitro and in vivo: RNAseq dataset
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Factors Influencing Bone Block Allograft Resorption
ClinicalTrials.gov study NCT03412838. IPD Sharing: NO. Countries: 0. Publications: 52.
Exercise Mode and Acute Bone Resorption
ClinicalTrials.gov study NCT04815824. IPD Sharing: NO. Countries: 1. Publications: 0.
Soluble Corn Fiber Effect on Bone Resorption in Post Menopausal Women
ClinicalTrials.gov study NCT02416947. IPD Sharing: Not stated. Countries: 0. Publications: 1.
Ph I/II of Vitamin D on Bone Mineral Density & Markers of Bone Resorption
ClinicalTrials.gov study NCT00904423. IPD Sharing: NO. Countries: 1. Publications: 0.
Data from: Piceatannol attenuates RANKL-induced osteoclast differentiation and bone resorption and promotes caspase3-mediated apoptosis of mature osteoclasts
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
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DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.