Find research datasets worth reusing
Search datasets from major research repositories and use ShareScore to quickly assess how well each record supports discovery, access, and reuse.
32
datasets available to search
ShareScore release 0.9.0
Dataset results
32 results for “brain lateralization”
A P300 Brain Computer Interface Keyboard to Control Assistive Technology For Use by People With Amyotrophic Lateral Sclerosis
ClinicalTrials.gov study NCT01119001. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Sheep brain lateral view
Drawing uploaded to scidraw.io on: 04 June 2020
Examining the Effect of Lateralization Imagery Training on EEG Brain Oscillations in Individuals With Chronic Neck Pain
ClinicalTrials.gov study NCT06679335. IPD Sharing: NO. Countries: 1. Publications: 36.
Evaluation of the Impact of Laterality on Brain Activation During a Virtual Mirror Therapy Task in Healthy Subjects
ClinicalTrials.gov study NCT05793762. IPD Sharing: Not stated. Countries: 1. Publications: 10.
Deep Brain Stimulation of the Lateral Hypothalamus to Augment Motor Function of Patients With Spinal Cord Injury
ClinicalTrials.gov study NCT04965727. IPD Sharing: NO. Countries: 1. Publications: 10.
A multimodal longitudinal study of structural brain involvement in amyotrophic lateral sclerosis
<p>Objective: To understand the progressive nature of amyotrophic lateral sclerosis (ALS) by investigating differential brain patterns of gray and white matter involvement in clinically or genetically defined subgroups of patients using cross-sectional, longitudinal and multimodal MRI.</p> <p>Methods: We assessed cortical thickness, subcortical volumes and white matter connectivity from T1-weighted and diffusion-weighted MRI in 292 ALS patients (follow-up: n=150) and 156 controls (follow-up: n=72). Linear mixed-effects models were used to assess changes in structural brain measurements over time in patients compared to controls.</p> <p>Results: Patients with a C9orf72 mutation (n=24) showed widespread gray and white matter involvement at baseline, and extensive loss of white matter integrity in the connectome over time. In C9orf72-negative patients, we detected cortical thinning of motor and frontotemporal regions, and loss of white matter integrity of connections linked to the motor cortex. Spinal-onset patients displayed widespread white matter involvement at baseline and gray matter atrophy over time, whereas bulbar-onset patients started out with prominent gray matter involvement. Patients with unaffected cognition or behavior displayed predominantly motor system involvement, while widespread cerebral changes, including frontotemporal regions with progressive white matter involvement over time, were associated with impaired behavior or cognition. Progressive loss of gray and white matter integrity typically occurred in patients with shorter disease durations (<13 months), independent of progression rate.</p> <p>Conclusions: Heterogeneity of phenotype and C9orf72 genotype relates to distinct patterns of cerebral degeneration. We demonstrate that imaging studies have the potential to monitor disease progression and early intervention may be required to limit cerebral degeneration.</p>
Data from: Lateralized feeding behavior is associated with asymmetrical neuroanatomy and lateralized gene expressions in the brain in scale-eating cichlid fish
Lateralized behavior ('handedness') is unusual, but consistently found across diverse animal lineages, including humans. It is thought to reflect brain anatomical and/or functional asymmetries, but its neuro-molecular mechanisms remain largely unknown. Lake Tanganyika scale-eating cichlid fish, Perissodus microlepis show pronounced asymmetry in their jaw morphology as well as handedness in feeding behavior – feeding scales preferentially only from one or the other side of their victims. This makes them an ideal model in which to investigate potential laterality in neuroanatomy and transcription in the brain in relation to behavioral handedness. After determining behavioral handedness in P. microlepis (preferred attack side), we estimated the volume of the hemispheres of brain regions and captured their gene expression profiles. Our analyses revealed that the degree of behavioral handedness is mirrored at the level of neuroanatomical asymmetry, particularly in the tectum opticum. Transcriptome analyses showed that different brain regions (tectum opticum, telencephalon, hypothalamus and cerebellum) display distinct expression patterns, potentially reflecting their developmental interrelationships. For numerous genes in each brain region, their extent of expression differences between hemispheres was found to be correlated with the degree of behavioral lateralization. Interestingly, the tectum opticum and telencephalon showed divergent biases on the direction of up- or down-regulation of the laterality candidate genes (e.g., grm2) in the hemispheres, highlighting the connection of handedness with gene expression profiles and the different roles of these brain regions. Hence, handedness in predation behavior may be caused by asymmetric size of brain hemispheres and also by lateralized gene expressions in the brain.
Cognitive Outcomes of Brain Stimulation As a Later-in-Life Treatment
ClinicalTrials.gov study NCT05564715. IPD Sharing: NO. Countries: 1. Publications: 0.
Brain Function in Primary Lateral Sclerosis
ClinicalTrials.gov study NCT00071435. IPD Sharing: Not stated. Countries: 1. Publications: 3.
Brain Function in Primary Lateral Sclerosis and Amyotrophic Lateral Sclerosis
ClinicalTrials.gov study NCT00334516. IPD Sharing: Not stated. Countries: 1. Publications: 5.
A multimodal longitudinal study of structural brain involvement in amyotrophic lateral sclerosis
Open the record for dataset details and reuse information.
Data from: Lateralized feeding behavior is associated with asymmetrical neuroanatomy and lateralized gene expressions in the brain in scale-eating cichlid fish
Open the record for dataset details and reuse information.
Data from: Neutral genetic variation in adult Chinook salmon (Oncorhynchus tshawytscha) affects brain-to-body trade-off and brain laterality
Open the record for dataset details and reuse information.
Data from: Large-brained frogs mature later and live longer
Open the record for dataset details and reuse information.
5-methylcytosine ChIP-on-Chip (MeDIP) of sporadic amyotrophic lateral sclerosis and control human brains
GEO Series GSE12525. Homo sapiens. 148 samples. Type: Methylation profiling by genome tiling array.
Chd8 haploinsufficiency impairs early brain development and impacts protein homeostasis later in life
GEO Series GSE142208. Mus musculus. 48 samples. Type: Expression profiling by high throughput sequencing.
A panel of TDP-43-regulated splicing events verifies loss of TDP-43 function in amyotrophic lateral sclerosis brain tissue
GEO Series GSE223747. Homo sapiens. 18 samples. Type: Expression profiling by high throughput sequencing; Other.
Dataset related to article: "Development of a nanocarrier-based approach for the blood-brain barrier passage in a murine model of amyotrophic lateral sclerosis"
<p>Raw data figures 3, 4, 5, 6</p>
Simultaneous Measurement of Both Fetal's Lateral Ventricles of the Brain
ClinicalTrials.gov study NCT01178541. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Intravenous Immunoglobulin (IVIG) and Blood-Brain Barrier Disruption in Amyotrophic Lateral Sclerosis (ALS)
ClinicalTrials.gov study NCT07193953. IPD Sharing: NO. Countries: 1. Publications: 0.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.