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190 results for “brain metabolism”
Data set related to "Secretory and metabolic determinants of brain metastasis"
<p>This repository includes the data sets related to the publication titled "Secretory and metabolic determinants of brain metastasis"</p>
Exploratory analysis of sleep deprivation effects on gene expression and regional brain metabolism
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Data from: Reconfiguration of functional brain networks and metabolic cost converge during task performance
<p>The ability to solve cognitive tasks depends upon adaptive changes in the organization of whole-brain functional networks. However, the link between task-induced network reconfigurations and their underlying energy demands is poorly understood. We address this by multimodal network analyses integrating functional and molecular neuroimaging acquired concurrently during a complex cognitive task. Task engagement elicited a marked increase in the association between glucose consumption and functional brain network reorganization. This convergence between metabolic and neural processes was specific to feedforward connections linking the visual and dorsal attention networks, in accordance with task requirements of visuo-spatial reasoning. Further increases in cognitive load above initial task engagement did not affect the relationship between metabolism and network reorganization but only modulated existing interactions. Our findings show how the upregulation of key computational mechanisms to support cognitive performance unveils the complex, interdependent changes in neural metabolism and neuro-vascular responses.</p>
The metabolic representation of ischemia in rat brain slices: A hyperpolarized 13 C magnetic resonance study
<p>This dataset contains primary data for DOI: 10.1002/nbm.4509</p><p>NMR in Biomedicine. 2021; 34(7):e4509</p><p>Title: The metabolic representation of ischemia in rat brain slices: A hyperpolarized 13 C magnetic resonance study </p><p>Authors: David Shaul , Benjamin Grieb, Gal Sapir, Sivaranjan Uppala, Jacob Sosna, J Moshe Gomori, Rachel Katz-Brull</p><p> </p><p>These primary datasets contain data related to the above publication and consist of 31P (thermal equilibrium) and hyperpolarized 13C -NMR spectra. </p><p>Please consult the Archive Guide.</p>
Whole-transcriptome sequencing identifies neuroinflammation, metabolism and blood-brain barrier related processes in the hippocampus of aged mice during perioperative period
<p><span><strong>Aim</strong>:</span><span> Perioperative neurocognitive disorders (PND) occur frequently after surgery and anesthesia, especially in aged patients. Previous studies have shown multiple PND related mechanisms in the hippocampus, however, their relationships remain unclear. Meanwhile, the perioperative neuropathological processes are sophisticated and changeable, single period study could not reveal the accurate mechanisms. Thus, multiperiod whole-transcriptome study is necessary to elucidate the gene expression patterns during perioperative period.</span></p> <p><span><strong>Methods</strong>: </span><span>Aged</span><span> C57BL/6 mice were subjected to exploratory laparotomy under sevoflurane anesthesia. Whole-transcriptome sequencing (RNA-seq analysis) was performed on the hippocampi from control condition (Con), 30 minutes (Day0), 2 days (Day2) and 7 days (Day7) after surgery. Gene Ontology</span><span>/Kyoto Encyclopedia of Genes and Genomes analyses,</span><span> quantitative Real-Time PCR, immunofluorescence and fear conditioning test were also performed to elucidate the pathological processes and modulation networks during the period.</span></p> <p><span><strong>Results</strong>: </span><span>Through RNA-seq analysis, 328, 3597 and 4179 differentially expressed genes (DEGs) were screened out in intraoperative period (Day0 vs Con), early postoperative period (Day2 vs Day0) and late postoperative period (Day7 vs Day2). The involved GO biological processes were divided into 9 categories, and positive-regulated processes were more than negative-regulated ones. Seventy-four transcription factors were highlighted. The potential synaptic and neuroinflammatory pathways were constructed for Neurotransmitter, Synapse and Neuronal alteration categories with 9 DEGs (<em>Htr1a, Rims1, Ezh2,</em> etc.). The metabolic and mitochondrial pathways were constructed for Metabolism, Oxidative stress and Biological rhythm categories with 9 DEGs (<em>Gpld1, Sirt1, Cry2, </em>etc.). The blood-brain barrier and neurotoxicity related pathways were constructed for Blood-brain barrier, Neurotoxicity and Cognitive function categories with 10 DEGs (<em>Mmp2, Itpr1, Nrf1, </em>etc.).</span></p> <p><span><strong>Conclusion</strong>:</span><span> The results revealed gene expression patterns and modulation networks in the aged hippocampus during perioperative period, which provide insights into overall mechanisms and potential therapeutic targets for prevention and treatment of perioperative central nervous system diseases, such as PND, from the genetic level.</span></p>
Calorie restriction and pravastatin administration during pregnancy in obese rhesus macaques modulates maternal and infant metabolism and infant brain and behavioral development
<p>Maternal obesity has been associated with a higher risk of pregnancy-related complications in mothers and offspring; however, effective interventions have not yet been developed. We tested two common interventions, calorie restriction and pravastatin administration, during pregnancy in a rhesus macaque model with the hypothesis that these interventions would normalize metabolic dysregulation in pregnant mothers leading to an improvement in infant metabolic and cognitive/social development. A total of 19 obese mothers were assigned to either one of the two intervention groups (n=5 for calorie restriction; n=7 for pravastatin) or an obese control group (n=7) with no intervention, and maternal gestational samples and postnatal infant samples were compared with lean control mothers (n=6). Gestational calorie restriction normalized one-carbon metabolism dysregulation in obese mothers but altered energy metabolism in their offspring. Although administration of pravastatin during pregnancy tended to normalize blood cholesterol in the mothers, it potentially impacted the gut microbiome and kidney function of their offspring. In the offspring, both calorie restriction and pravastatin administration during pregnancy tended to normalize the activity of AMPK in the brain at 6 months, and while results of the Visual Paired-Comparison test, which measures infant recognition memory, were not significantly impacted by either of the interventions, gestational pravastatin administration, but not calorie restriction, tended to normalize anxiety assessed by the Human Intruder test. Although the two interventions tested in a non-human primate model led to some improvements in metabolism and/or infant brain development, negative impacts were also found in both mothers and infants. Our study emphasizes the importance of assessing gestational interventions for maternal obesity on both maternal and offspring long-term outcomes.</p>
The Effects of Antipsychotic Drugs on Brain Metabolism in Healthy Individuals
ClinicalTrials.gov study NCT02536846. IPD Sharing: Not stated. Countries: 1. Publications: 13.
Effect of Red Blood Cell Transfusion on Brain Metabolism in Patients With Subarachnoid Hemorrhage
ClinicalTrials.gov study NCT00968227. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Deep Brain Stimulation Effects on Weight Change and Metabolic Rate
ClinicalTrials.gov study NCT01933113. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Acute Effect of Exenatide on Brain Glucose Metabolism
ClinicalTrials.gov study NCT01588418. IPD Sharing: NO. Countries: 1. Publications: 2.
Ketone Ester Effects on Biomarkers of Brain Metabolism and Cognitive Performance in Cognitively Intact Adults 55 Years Old or Older
ClinicalTrials.gov study NCT04421014. IPD Sharing: UNDECIDED. Countries: 1. Publications: 3.
Calorie restriction and pravastatin administration during pregnancy in obese rhesus macaques modulates maternal and infant metabolism and infant brain and behavioral development
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Whole-transcriptome sequencing identifies neuroinflammation, metabolism and blood-brain barrier related processes in the hippocampus of aged mice during perioperative period
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Data from: Fatty acid binding protein 7 plays an important modulatory sex-dependent role on brain THC metabolism
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Data from: Reconfiguration of functional brain networks and metabolic cost converge during task performance
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Effects of bariatric surgery and dietary interventions for obesity on brain neurotransmitter systems and metabolism: a systematic review of positron emission tomography (PET) and single-photon emission computed tomography (SPECT) studies
<p>Supplementary material for paper:</p> <p><span>Effects of bariatric surgery and dietary interventions for obesity on brain neurotransmitter systems and metabolism: a systematic review of positron emission tomography (PET) and single-photon emission computed tomography (SPECT) studies<em>.<br></em></span>Al-Alsheikh AS<span>, Alabdulkader S, Miras AD, Goldstone AP <br></span><span>Obesity Reviews 24(11): e13620, 2023 </span></p>
PhytoSERM to Prevent Menopause Associated Decline in Brain Metabolism and Cognition
ClinicalTrials.gov study NCT05664477. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Metabolic Activation of Brain Areas With Emotional Stimuli Compared With Score in Psychological Test
ClinicalTrials.gov study NCT04974437. IPD Sharing: YES. Countries: 1. Publications: 7.
The Role of Estrogen and Testosterone in Determining Brain Blood Flow and Metabolic Regulation in Humans
ClinicalTrials.gov study NCT07212712. IPD Sharing: UNDECIDED. Countries: 1. Publications: 3.
Tryptophan Metabolism in Human Brain Tumors
ClinicalTrials.gov study NCT02367469. IPD Sharing: NO. Countries: 1. Publications: 9.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.