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7 results for “brain reserve”
Effects of brain maintenance and cognitive reserve on age-related decline in three cognitive abilities
<p><strong>Objectives </strong></p> <p>Age-related cognitive changes can be influenced by both brain maintenance (BM), which refers to the relative absence over time of changes in neural resources or neuropathologic changes, and cognitive reserve (CR), which encompasses brain processes that allow for better-than-expected behavioral performance given the degree of life-course related brain changes. This study evaluated the effects of age, BM, and CR on longitudinal changes over two visits, 5 years apart, in three cognitive abilities that capture most of age-related variability.</p> <p><strong>Method </strong></p> <p>Participants included 254 healthy adults aged 20–80 years at recruitment. Potential BM was estimated using whole brain cortical thickness and white matter mean diffusivity at both visits. Education and IQ (estimated with AMNART) were tested as moderating factors for cognitive changes in the three cognitive abilities.</p> <p><strong> Results </strong></p> <p>Consistent with BM—after accounting for age, sex, and baseline performance—individual differences in the preservation of mean diffusivity and cortical thickness were independently associated with relative preservation in the three abilities. Consistent with CR—after accounting for age, sex, baseline performance, and structural brain changes—higher IQ, but not education, was associated with reduced 5-year decline in Reasoning (𝛽=0.387, p=0.002), and education was associated with reduced decline in Speed (𝛽=0.237, p=0.039). <strong> </strong></p> <p><strong>Discussion</strong></p> <p>These results demonstrate that both CR and BM can moderate cognitive changes in healthy aging and that the two mechanisms can make differential contributions to preserved cognition.</p>
Effects of brain maintenance and cognitive reserve on age-related decline in three cognitive abilities
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Supplementary materials for: Influence of cognitive reserve on cognitive trajectories: role of brain pathologies
<p><span><b>Background and Objectives:</b> </span>Evidence on the association of the cognitive reserve (CR) with the cognitive trajectories is limited. We aimed to examine the influence of CR indicator on domain-specific cognitive trajectories taking brain pathologies into account.</p> <p><span><b>Methods:</b> Within the Rush Memory and Aging Project, 1,697 dementia-free participants (mean age: 79.6 years) were followed up to 21 years. CR indicator encompassing education, early-life, mid-life, and late-life cognitive activities, and late-life social activity was ascertained at baseline and categorized as tertiles (the lowest, middle, and highest). Global cognition, episodic memory, semantic memory, working memory, visuospatial ability, and perceptual speed were assessed annually with 19 tests, from which composite scores were derived. During the follow-up, 648 died and underwent autopsies to evaluate brain pathologies. Data were analyzed using linear mixed-effect models.</span></p> <p><span><b>Results:</b> Among the participants, the score of the CR indicator ranged from -8.00 to 5.74 (mean: 0.00±2.23). In multi-adjusted mixed-effect models, compared to the lowest CR, the highest was related to a slower decline in global cognition (β=0.028, 95% confidence interval [CI]: 0.012 to 0.043), episodic memory (β=</span>0.028, 95% CI: 0.010 to 0.047<span>) and working memory (β=0.019, 95% CI: 0.005 to 0.033) during the follow-up. In brain pathological data analysis, the association of the highest CR with cognitive function changes remained significant among participants with high Alzheimer's disease pathology or gross infarcts.</span></p> <p><b>Discussion</b><span><b>:</b> High CR indicator is associated with preserved global cognitive function, episodic memory, and working memory, even in the presence of brain pathologies. </span>Our findings highlight the important role of high CR accumulation in the prevention of cognitive decline.</p>
The Effect of Cognitive Reserve on Outcome After Stroke or Traumatic Brain Injury
ClinicalTrials.gov study NCT05407948. IPD Sharing: NO. Countries: 1. Publications: 30.
Supplementary materials for: Influence of cognitive reserve on cognitive trajectories: role of brain pathologies
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Study of Reserves After Traumatic Brain Injury
ClinicalTrials.gov study NCT01628003. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Brain and Cognitive Reserve
ClinicalTrials.gov study NCT02819167. IPD Sharing: Not stated. Countries: 1. Publications: 0.
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.