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18 results for “cGMP”
Extensive Checklist to cGMP Inspections in Pharmaceutical Manufacturing Plants
<p><span>cGMP inspections are an essential part of ensuring that pharmaceutical companies produce high-quality, safe, and effective drugs. These inspections help maintain the integrity of the pharmaceutical supply chain and protect public health. Pharmaceutical companies must prioritize continuous cGMP compliance, prepare thoroughly for inspections, and respond promptly to any observations made by inspectors to remain in good standing with regulatory authorities.</span></p> <p><span>Here's a comprehensive cGMP inspection checklist for a pharmaceutical company, incorporating requirements from USFDA, EMA, WHO, UKMHRA, TGA, and ANVISA. This checklist includes a rating system to evaluate compliance with each requirement.</span></p>
The inner mechanics of rhodopsin guanylyl cyclase during cGMP-formation revealed by real-time FTIR spectroscopy
<p>Enzymerhodopsins represent a recently discovered class of rhodopsins which includes histidine kinase rhodopsin, rhodopsin phosphodiesterases and rhodopsin guanylyl cyclases (RGCs). The regulatory influence of the rhodopsin domain on the enzyme activity is only partially understood and holds the key for a deeper understanding of intra-molecular signaling pathways. Here we present a UV-Vis and FTIR study about the light-induced dynamics of a RGC from the fungus <em>Catenaria anguillulae</em>, which provides insights into the catalytic process. After the spectroscopic characterization of the late rhodopsin photoproducts, we analyzed truncated variants and revealed the involvement of the cytosolic N-terminus in the structural rearrangements upon photo-activation of the protein. We tracked the catalytic reaction of RGC and the free GC domain independently by UV-light induced release of GTP from the photolabile NPE-GTP substrate. Our results show substrate binding to the dark-adapted RGC and GC alike and reveal differences between the constructs attributable to the regulatory influence of the rhodopsin on the conformation of the binding pocket. By monitoring the phosphate rearrangement during cGMP and pyrophosphate formation in light-activated RGC, we were able to confirm the M state as the active state of the protein. The described setup and experimental design enable real-time monitoring of substrate turnover in light-activated enzymes on a molecular scale, thus opening the pathway to a deeper understanding of enzyme activity and protein-protein interactions.</p>
A Study in Healthy Men to Test How Different Doses of BI 474121 Are Taken up and How They Influence the Amount of a Molecular Messenger (cGMP) in the Spinal Fluid
ClinicalTrials.gov study NCT04672954. IPD Sharing: NO. Countries: 1. Publications: 1.
Data from: Two cGMP-dependent protein kinases have opposing effects on molt-inhibiting hormone regulation of Y-organ ecdysteroidogenesis
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The inner mechanics of rhodopsin guanylyl cyclase during cGMP-formation revealed by real-time FTIR spectroscopy
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Optogenetic silencing by combining a rhodopsin cyclase with an engineered cGMP-gated potassium channel
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The Effects of CGMP in Children and Adults With PKU
ClinicalTrials.gov study NCT04076176. IPD Sharing: NO. Countries: 2. Publications: 1.
Safety and Efficacy Study of CVD 1208S, a Live, Attenuated Oral Vaccine to Prevent Shigella Infection Using cGMP
ClinicalTrials.gov study NCT01531530. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Data from: An ant–plant mutualism through the lens of cGMP-dependent kinase genes
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Assessment of Exposure of BI 409306 in Cerebrospinal Fluid (CSF) Relative to Plasma as Well as to Evaluation of the Effect of Different Doses of BI 409306 on the cGMP (Cyclic Guanosine Monophosphate)
ClinicalTrials.gov study NCT01493570. IPD Sharing: NO. Countries: 1. Publications: 0.
cGMP inducer effect on cell line Panc-1
GEO Series GSE66403. Homo sapiens. 2 samples. Type: Expression profiling by array.
Naringenin modulates the NO-cGMP-PKG signaling pathway through AKT binding to enhance osteogenic differentiation in hPDLSCs
GEO Series GSE266150. Homo sapiens. 8 samples. Type: Expression profiling by high throughput sequencing.
cGMP: Metabolism and Appetite Modulation
ClinicalTrials.gov study NCT06794515. IPD Sharing: NO. Countries: 1. Publications: 0.
Elevated Extracellular cGMP Produced after Exposure to Enterotoxigenic Escherichia coli (ETEC) Heat-Stable Toxin (ST) Induces Epithelial IL-33 Release and Alters Intestinal Immunity
GEO Series GSE162393. Homo sapiens. 12 samples. Type: Expression profiling by high throughput sequencing; Non-coding RNA profiling by high throughput sequencing.
cGMP-dependent protein kinase 1 (cGK1) modulates human hepatic stellate cell activation
GEO Series GSE111988. Mus musculus. 6 samples. Type: Expression profiling by array.
cGMP
Drawing uploaded to scidraw.io on: 12 March 2020
cGMP
Drawing uploaded to scidraw.io on: 12 March 2020
Marked Disparity of MicroRNA Modulation by cGMP-selective PDE5 versus PDE9 Inhibitors in Heart Disease
GEO Series GSE112056. Mus musculus. 42 samples. Type: Non-coding RNA profiling by high throughput sequencing; Expression profiling by high throughput sequencing.
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.