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3 results for “cacophony”
Replication data for Nematzadeh et al. "Information Overload in Group Communication: From Conversation to Cacophony in the Twitch Chat"
<p>A subset of the chat logs dump from Twitch used in this work is provided, to help replicate the central findings of this work (<a href="https://doi.org/10.5281/zenodo.1182793">https://doi.org/10.5281/zenodo.1182793</a>). Data are aggregated and include the number of messages posted in each channel and the number of users posting them, sampled at intervals of 5 minutes. To protect the identity of the users in this data collection, message contents and user names are not included in this dataset. Stream names have been replaced with numeric IDs. <br> No additional filtering or data cleaning operation has been applied to this data. Replication code is available on Github (<a href="https://github.com/glciampaglia/twitch-overload-replication">https://github.com/glciampaglia/twitch-overload-replication</a>).</p>
Data from: Mutations of the calcium channel gene cacophony suppress seizures in Drosophila
Bang sensitive (BS) Drosophila mutants display characteristic seizure-like phenotypes resembling, in some aspects, those of human seizure disorders such as epilepsy. The BS mutant parabss1, caused by a gain-of-function mutation of the voltage-gated Na+ channel gene, is extremely seizure-sensitive with phenotypes that have proven difficult to ameliorate by anti-epileptic drug feeding or by seizure-suppressor mutation. It has been presented as a model for intractable human epilepsy. Here we show that cacophony (cacTS2), a mutation of the Drosophila presynaptic Ca++ channel α1 subunit gene, is a particularly potent seizure-suppressor mutation, reverting seizure-like phenotypes for parabss1 and other BS mutants. Seizure-like phenotypes for parabss1 may be suppressed by as much as 90% in double mutant combinations with cacTS2. Unexpectedly, we find that parabss1 also reciprocally suppresses cacTS2 seizure-like phenotypes. The cacTS2 mutant displays these seizure-like behaviors and spontaneous high-frequency action potential firing transiently after exposure to high temperature. We find that this seizure-like behavior in cacTS2 is ameliorated by 85% in double mutant combinations with parabss1.
Data from: Mutations of the calcium channel gene cacophony suppress seizures in Drosophila
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