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71 results for “calcium signaling”
Рис. 2. Варианты преΑсказанной Αоменной структуры патогенраспознающих моΛекуΛ гемоцитов моΛΛюсков Planorbarius corneus. a — фибриногенпоΑобные беΛки, b — гаΛектины, c — F-Λектины. УсΛовные обозначения и сокращения, зΑесь и ΑаΛее: горизонтаΛьные красные поΛоски — сигнаΛьный пептиΑ, горизонтаΛьные розовые — обΛасть низкой сΛожности, вертикаΛьные синие поΛоски — трансмембранная обΛасть, FBG — фибриногеновый Αомен, FTP — Αомен фукоΛектина, EGF — Αомен эпиΑермаΛьного фактора роста, EGF_CA — каΛьцийсвязывающий EGF-поΑобный Αомен, PAN_AP — APPLE-поΑобный Αомен, SCAN — обΛасть, богатая Λейцином, GLECT — гаΛактозосвязывающий Λектин, CLECT — Λектин C-типа, Gal-bind — гаΛактозиΑ–связывающий Λектин, ML — MD-2- поΑробный Αомен распознавания ΛипиΑов Fig. 2. Variants of the predicted domain structure of pattern recognition molecules from hemocytes of Planorbarius corneus molluscs. a — fibrinogen-related proteins, b — galectins, c — F-lectins. Symbols and abbreviations (here and further): horizontal red stripes — signal peptide, horizontal pink stripes — a low complexity region, vertical blue stripes — transmembrane region, FBG — fibrinogen-related domain, FTP — fucolectin domain, EGF — epidermal growth factor-like domain, EGF_CA — calcium-binding EGF-like domain, PAN_AP — APPLE-like domain, SCAN — leucine rich region, Apple — APPLE domain, GLECT — galactose-binding lectin, CLECT — C-type lectin, Gal-bind — galactoside-binding lectin, ML — MD-2-related lipid-recognition domain in Pathogen recognition molecules from hemocytes of Planorbarius corneus molluscs (Planorbidae, Pulmonata)
Рис. 2. Варианты преΑсказанной Αоменной структуры патогенраспознающих моΛекуΛ гемоцитов моΛΛюсков Planorbarius corneus. a — фибриногенпоΑобные беΛки, b — гаΛектины, c — F-Λектины. УсΛовные обозначения и сокращения, зΑесь и ΑаΛее: горизонтаΛьные красные поΛоски — сигнаΛьный пептиΑ, горизонтаΛьные розовые — обΛасть низкой сΛожности, вертикаΛьные синие поΛоски — трансмембранная обΛасть, FBG — фибриногеновый Αомен, FTP — Αомен фукоΛектина, EGF — Αомен эпиΑермаΛьного фактора роста, EGF_CA — каΛьцийсвязывающий EGF-поΑобный Αомен, PAN_AP — APPLE-поΑобный Αомен, SCAN — обΛасть, богатая Λейцином, GLECT — гаΛактозосвязывающий Λектин, CLECT — Λектин C-типа, Gal-bind — гаΛактозиΑ–связывающий Λектин, ML — MD-2- поΑробный Αомен распознавания ΛипиΑов Fig. 2. Variants of the predicted domain structure of pattern recognition molecules from hemocytes of Planorbarius corneus molluscs. a — fibrinogen-related proteins, b — galectins, c — F-lectins. Symbols and abbreviations (here and further): horizontal red stripes — signal peptide, horizontal pink stripes — a low complexity region, vertical blue stripes — transmembrane region, FBG — fibrinogen-related domain, FTP — fucolectin domain, EGF — epidermal growth factor-like domain, EGF_CA — calcium-binding EGF-like domain, PAN_AP — APPLE-like domain, SCAN — leucine rich region, Apple — APPLE domain, GLECT — galactose-binding lectin, CLECT — C-type lectin, Gal-bind — galactoside-binding lectin, ML — MD-2-related lipid-recognition domain
Data from: A comprehensive suite for extracting neuron signals across multiple sessions in one-photon calcium imaging
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Action potential evoked dendritic calcium signals in the medial superior olive (MSO) during development
<p>Dataset underlying the analysis of dendritic calcium signals evoked by somatic action potentials in MSO neurons during development (postnatal day 10 - 60). The data includes recordings from Mongolian gerbils (<em>Meriones unguiculatus</em>) raised in a normal acoustic environment and in omnidirectional white noise.</p> <p><strong>Linked paper:</strong> Franzen DL, Gleiss SA, Kellner CJ, Kladisios N, Felmy F. Activity-Dependent Calcium Signaling in Neurons of the Medial Superior Olive during Late Postnatal Development. J Neurosci. 2020 Feb 19;40(8):1689–700. <a href="https://doi.org/10.1523/JNEUROSCI.1545-19.2020">https://doi.org/10.1523/JNEUROSCI.1545-19.2020</a>.</p> <p><strong>Files included:</strong></p> <ul> <li> <p>A folder entitiled <em>data</em> containing:</p> <ul> <li>The imaging files (<code>.nix</code>) (1 file per imaged neuron). NIX files contain the kymograph data extracted from a ROI in the raw images along with the metadata. The imaging kymographs and associated <code>.nix</code> files were created with the <a href="https://zenodo.org/record/2575542#.XiYdAS2ZNo4">CaManager: ImageJ Plugin For Ca²⁺ Imaging</a>.</li> <li>An <code>excludes.csv</code> file that contains cells/trials to be excluded (e.g. recording error, movement, difficulty in tracing)</li> <li>A <code>Megatable_C.csv</code> file containing the electrophysiological data corresponding to imaged cells</li> </ul> </li> <li> <p>A <code>.nix</code> intermediate analysis file for <em>default parameters</em></p> </li> <li> <p>A <code>.csv</code> file with the combined electrophysiological and imaging data for <em>default parameters</em></p> </li> <li> <p>Several <code>.xlsx</code> files with the single cell data in Figures 2C, 2D, 2F.</p> </li> </ul> <p><strong>Jupyter notebook:</strong></p> <p>The <a href="https://github.com/delwen/CaJupyter">CaJupyter</a> GitHub repository contains a Jupyter notebook with a step-by-step guide of the analysis. It also allows for further exploration of the data.</p> <p><strong>See also:</strong></p> <ul> <li> <p>The original analysis code (without adaptations for the Jupyter notebook and Python 3) can be found at <a href="https://zenodo.org/record/2575675#.Xi%E2%80%A6">CaAnalysis: Analysis Toolbox for Ca²⁺ Imaging</a>.</p> </li> <li> <p>More information on NIX can be found at this <a href="https://g-node.github.io/nix/">link</a>.</p> </li> </ul>
Dendritic calcium signals in rhesus macaque motor cortex drive an optical brain-computer interface
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Data from: Glutamate sensor and calcium signals in dopamine neurons and dopamine release
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Data from: Diethylcarbamazine elicits calcium signals in HEK293 cells by activation of heterologously expressed <em>Brugia malayi</em> TRP-2b channels
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Light calcium isotope anomaly observed in continental basaltic lavas: a mixed signal of recycled carbonate and fractionation during melting
<p>Table 1 and Supplementary Tables S1 to S7 which support for the manuscript 'Light calcium isotope anomaly observed in continental basaltic lavas: a mixed signal of recycled carbonate and fractionation during melting'.</p>
Data from: Efficient and accurate extraction of in vivo calcium signals from microendoscopic video data
In vivo calcium imaging through microendoscopic lenses enables imaging of previously inaccessible neuronal populations deep within the brains of freely moving animals. However, it is computationally challenging to extract single-neuronal activity from microendoscopic data, because of the very large background fluctuations and high spatial overlaps intrinsic to this recording modality. Here, we describe a new constrained matrix factorization approach to accurately separate the background and then demix and denoise the neuronal signals of interest. We compared the proposed method against previous independent components analysis and constrained nonnegative matrix factorization approaches. On both simulated and experimental data recorded from mice, our method substantially improved the quality of extracted cellular signals and detected more well-isolated neural signals, especially in noisy data regimes. These advances can in turn significantly enhance the statistical power of downstream analyses, and ultimately improve scientific conclusions derived from microendoscopic data.
Data from: Nitric oxide signals are interlinked with calcium signals in normal pancreatic stellate cells upon oxidative stress and inflammation
The mammalian diffuse stellate cell system comprises retinoid-storing cells capable of remarkable transformations from a quiescent to an activated myofibroblast-like phenotype. Activated pancreatic stellate cells (PSCs) attract attention owing to the pivotal role they play in development of tissue fibrosis in chronic pancreatitis and pancreatic cancer. However, little is known about the actual role of PSCs in the normal pancreas. These enigmatic cells have recently been shown to respond to physiological stimuli in a manner that is markedly different from their neighbouring pancreatic acinar cells (PACs). Here, we demonstrate the capacity of PSCs to generate nitric oxide (NO), a free radical messenger mediating, for example, inflammation and vasodilatation. We show that production of cytosolic NO in PSCs is unambiguously related to cytosolic Ca2+ signals. Only stimuli that evoke Ca2+ signals in the PSCs elicit consequent NO generation. We provide fresh evidence for the striking difference between signalling pathways in PSCs and adjacent PACs, because PSCs, in contrast to PACs, generate substantial Ca2+-mediated and NOS-dependent NO signals. We also show that inhibition of NO generation protects both PSCs and PACs from necrosis. Our results highlight the interplay between Ca2+ and NO signalling pathways in cell–cell communication, and also identify a potential therapeutic target for anti-inflammatory therapies.
Data from: Nitric oxide signals are interlinked with calcium signals in normal pancreatic stellate cells upon oxidative stress and inflammation
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Data from: Efficient and accurate extraction of in vivo calcium signals from microendoscopic video data
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Data from: Phenotypic variability in unicellular organisms: from calcium signaling to social behavior
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Urolithin A rewires inter-organellar communication via calcium signaling to promote mitophagy and longevity
GEO Series GSE279559. Caenorhabditis elegans. 8 samples. Type: Expression profiling by high throughput sequencing.
Calcium signaling is impaired in PTEN-deficient T cell acute lymphoblastic leukemia
GEO Series GSE186498. Mus musculus. 2 samples. Type: Expression profiling by high throughput sequencing.
Select EZH2 inhibitors enhance the viral mimicry effects of DNMT inhibition through a mechanism involving Calcium-Calcineurin-NFAT signaling [EPIC]
GEO Series GSE237553. Homo sapiens. 10 samples. Type: Methylation profiling by genome tiling array.
Integration of kinase and calcium signaling at the level of chromatin underlines inducible gene activation in T cells
GEO Series GSE90718. Homo sapiens. 27 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing.
TRPC1 links calcium signaling to cellular senescence in the protection against post-traumatic osteoarthritis
GEO Series GSE288320. Mus musculus. 7 samples. Type: Expression profiling by high throughput sequencing.
Differential Expression of Calcium Channels and Signaling Pathways in Hematologic Cancers
GEO Series GSE189927. Homo sapiens. 44 samples. Type: Expression profiling by high throughput sequencing.
Allopregnanolone Pleiotropic Action in Neurons and Astrocytes: Calcium Signaling Pathways as the Unifying Mechanism
GEO Series GSE229627. Rattus norvegicus. 14 samples. Type: Expression profiling by high throughput sequencing.
Select EZH2 inhibitors enhance the viral mimicry effects of DNMT inhibition through a mechanism involving Calcium-Calcineurin-NFAT signaling [siQ-ChIP]
GEO Series GSE236897. Homo sapiens. 15 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.