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Calcium time series of cortex in a rat model of cortical dysplasia

<p>In vitro Calcium time series of rat (P30) primary motor cortex, were recorder by a CCD camera coupled to stereo-fluoerscence<br> microscope, with a fs = 300ms, following the next sequence: <strong>Basal, <em>Stimulus</em>, Rest.</strong></p> <p>All data is included in a compressed file named <strong>calcium_timeseries.tar.gz.</strong></p> <p>There are two groups of rats:&nbsp;<strong>Control</strong>&nbsp;(control animals), and <strong>BCNU</strong>&nbsp;(experimental animals using the BCNU/carmustine model of cortical dysplasia [1]).</p> <p>Time series are stored in .<strong>csv</strong>&nbsp;files with file names as <strong>R?Pilo-KCl.csv</strong>&nbsp;(where <strong>?</strong>&nbsp;indicates the rat ID). Each of these files holds the two recordings, one for each <em>Stimulus</em>, the first being&nbsp;<em>pilocarpine</em>, followd by&nbsp;<em>KCl</em>&nbsp;used as a control of cellular activity.&nbsp;&nbsp;(pilocarpine, KCl).&nbsp;&nbsp;recording session:&nbsp;The first 150 seconds of these time series correspond to basal activity, followed by 30 s of pilocarpine stimulus, and the rest of spontaneous activity after stimulation, for a total of 15 minutes for each <em>Stimulus</em>. The number of cells recorded varied between animals, as indicated by the number of columns in these .csv&nbsp;files. All of these files have the same number of rows (6000), with each row indicating a frame in the time series. The file <strong>dataEx.png</strong> illustrates this organization.</p> <p>Files named <strong>R?-Coor.csv</strong>&nbsp;(<strong>?</strong>&nbsp;indicates rat ID) show the <em>x</em> and <em>y</em> coordinates of every recorded cell, one for each row, ordered as<br> they appear in the calcium activity recordings.&nbsp;</p> <p><br> Authors:</p> <ul> <li>Ana Aquiles anaaquiles@ciencias.unam.mx</li> <li>Tatiana Fiordelisio tfiorde@ciencias.unam.mx</li> <li>Hiram Luna-Mungu&iacute;a hiram_luna@inb.unam.mx</li> <li>Luis Concha lconcha@unam.mx</li> </ul> <p>&nbsp;</p> <p>1.&nbsp;Benardete, E. A., &amp; Kriegstein, A. R. (2002). Increased excitability and decreased sensitivity to GABA in an animal model of dysplastic cortex.&nbsp;<em>Epilepsia</em>,&nbsp;<em>43</em>(9), 970-982.</p>