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17 results for “cardiolipin”
NAMD Trajectory of a Tetraoleoyl Cardiolipin Bilayer
<p>All-atom TOCL (tetraoleoyl cardiolipin) bilayer simulated in NPT ensemble with NAMD and the CHARMM36 force field from Doktorova et al. 2017 Phys. Chem. Chem. Phys. article (DOI 10.1039/c7cp01921a). The trajectory represents the last 155 ns used for analysis where the area per lipid is equilibrated (the file has 7752 frames output every 20 ps). The bilayer has 100 lipids total (50 lipids per leaflet) and is hydrated with 60 waters/lipid and 140mM NaCl. The simulation was done at 30C (303.15K) and the trajectory is centered on the bilayer midplane.</p>
Supporting data for: "Data-driven discovery of cardiolipin-selective small molecules by computational active learning"
<p>This repository contains supporting data and code for the paper titled "Data-driven discovery of cardiolipin-selective small molecules by computational active learning" by Bernadette Mohr, Kirill Shmilovich, Isabel Kleinwächter, Dirk Schneider, Andrew L.Ferguson, and Tristan Bereau.</p>
Preliminary data on analysis of cardiolipin from mouse tissue
<p>Negative mode LC-ESI-MS/MS data acquired on Exploris 480. Dilution series of cardiolipin authentic standard and analysis of mouse tissue extracts for the screening of cardiolipins.</p>
Data from: Dietary macronutrients modulate the fatty acyl composition of rat liver mitochondrial cardiolipins
The interaction of dietary fats and carbohydrates on liver mitochondria were examined in male FBNF1 rats fed 20 different low-fat, isocaloric diets. Animal growth rates and mitochondrial respiratory parameters were essentially unaffected, but mass spectrometry-based, mitochondrial lipidomics profiling revealed increased levels of cardiolipins (CLs), a family of phospholipids essential for mitochondrial structure and function, in rats fed saturated or trans fat-based diets with a high glycemic index. These mitochondria showed elevated monolysocardiolipins (a CL precursor/product of CL degradation), elevated ratio of trans PC (18:1/18:1) to cis PC (18:1/18:1) (a marker of thiyl radical stress), and decreased ubiquinone Q9 -- the latter two of which imply a low-grade mitochondrial redox abnormality. Extended analysis demonstrated: (i) dietary fats and, to a lesser extent, carbohydrates induce changes in the relative abundance of specific CL species; (ii) Fatty acid (FA) incorporation into mature CLs undergoes both positive (>400-fold) and negative (2.5-fold) regulation; and, (iii) dietary lipid abundance and incorporation of FAs into both the CL pool and specific mature tetra-acyl CLs are inversely related, suggesting previously unobserved compensatory regulation. This study reveals previously unobserved complexity/regulation of the central lipid in mitochondrial metabolism.
Data from: Dietary macronutrients modulate the fatty acyl composition of rat liver mitochondrial cardiolipins
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Cardiolipin Synthesis Governs Systemic Energy Homeostasis through Thermogenic Fat Mitochondria
GEO Series GSE110297. Mus musculus. 10 samples. Type: Expression profiling by high throughput sequencing.
Cardiolipin is required for membrane docking of mitochondrial ribosomes and protein synthesis
GEO Series GSE148178. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing.
Genome-wide analysis of gene transcription in myocardium of mice transgenically expressing human cardiolipin synthase 1 (hCLS1) in cardiac tissue
GEO Series GSE33451. Mus musculus. 8 samples. Type: Expression profiling by array.
Defective mitochondrial cardiolipin remodeling dampens HIF-1a expression in hypoxia
GEO Series GSE119775. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing.
Re-expression of tafazzin isoforms in TAZ-deficient C6 glioma cells restores cardiolipin composition but not proliferation rate and alterations in gene expression
GEO Series GSE207004. Rattus norvegicus. 2 samples. Type: Expression profiling by array.
ABHD18 is essential for cardiolipin remodeling and its inhibition restores mitochondrial function in Barth Syndrome
GEO Series GSE297454. Homo sapiens. 46 samples. Type: Other; Expression profiling by high throughput sequencing.
TFPa/HADHA is required for fatty acid beta-oxidation and cardiolipin re-modeling in human cardiomyocytes
GEO Series GSE135595. Homo sapiens. 28 samples. Type: Expression profiling by high throughput sequencing.
ABHD18 is essential for cardiolipin remodeling and its inhibition restores mitochondrial function in Barth Syndrome [CRISPR]
GEO Series GSE276191. Homo sapiens. 28 samples. Type: Other.
ABHD18 is essential for cardiolipin remodeling and its inhibition restores mitochondrial function in Barth Syndrome [RNA-Seq]
GEO Series GSE297335. Homo sapiens. 18 samples. Type: Expression profiling by high throughput sequencing.
Zc3h10 controls mitochondrial function coupling iron and cardiolipin homeostasis.
GEO Series GSE99138. Mus musculus. 13 samples. Type: Expression profiling by high throughput sequencing; Other.
Zc3h10 controls mitochondrial function coupling iron and cardiolipin homeostasis [RIP-seq]
GEO Series GSE99137. Mus musculus. 2 samples. Type: Other.
Zc3h10 controls mitochondrial function coupling iron and cardiolipin homeostasis [RNA-seq]
GEO Series GSE99136. Mus musculus. 11 samples. Type: Expression profiling by high throughput sequencing.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.