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90 results for “cardiovascular system”
Data set related to the article: "The Role of BPIFB4 in Immune System and Cardiovascular Disease: The Lesson from Centenarians."
<p>Abstract:</p> <p>Recent discoveries have shed light on the participation of the immune system in the physio pathology of the car- diovascular system underpinning the importance of keeping the balance of the first to preserve the latter. Aging, along with other risk factors, can challenge such balance triggering the onset of cardiovascular diseases.</p> <p>Among several mediators ensuring the proper cross-talk between the two systems, bactericidal/permeability- increasing fold-containing family B member 4 (BPIFB4) has been shown to have a pivotal role, also by sustaining important signals such as eNOS and PKC-alpha.</p> <p>In addition, the Longevity-associated variant (LAV), which is an haplotype allele in BPIFB4 characterized by 4 missense polymorphisms, enriched in homozygosity in Long Living Individuals (LLIs), has been shown to be efficient, if admin- istered systemically through gene therapy, in improving many aspects of cardiovascular diseases (CVDs). This occurs mainly through a fine immune system remodeling across: 1) a M2 macrophage polarizing effect, 2) a favorable redistri- bution of the circulating monocyte cell subsets and 3) the reduction of T-cell activation. Furthermore, LAV-BPIFB4 treat- ment induced a desirable recovery of the inflammatory balance by mitigating the pro-inflammatory factor levels and enhancing the anti-inflammatory boost through a mechanism that is partially dependent on SDF-1/CXCR4 axis.</p> <p>Importantly, the remarkable effects of LAV-BPIFB4 treatment, which translates in increased BPIFB4 circulating levels, mirror what occurs in long-living individuals (LLIs) in whom the high circulating levels of BPIFB4 are protective from age-related and CVDs and emphasize the reason why LLIs are considered a model of successful aging. Here, we review the mechanisms by which LAV-BPIFB4 exerts its immunomodulatory activity in improving the cardiovascular-immune system dialogue that might strengthen its role as a key mediator in CVDs.</p>
Study to Determine if Olmesartan Medoxomil Has the Potential to Benefit the Cardiovascular System in Terms of Arterial Protection
ClinicalTrials.gov study NCT00676845. IPD Sharing: YES. Countries: 3. Publications: 1.
Renin-angiotensin-aldosterone System Polymorphisms in Resistant Hypertension and Adverse Cardiovascular Events
ClinicalTrials.gov study NCT01173029. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Combined Effects of Prolonged Sitting and Mental Stress on the Cardiovascular System
ClinicalTrials.gov study NCT04207333. IPD Sharing: YES. Countries: 1. Publications: 0.
Characterization of Patients With Uncommon Presentations and/or Uncommon Diseases Associated With the Cardiovascular System
ClinicalTrials.gov study NCT01143454. IPD Sharing: UNDECIDED. Countries: 1. Publications: 2.
Technical Development of Cardiovascular Magnetic Resonance Imaging (CMR) Using a Low Specific Absorption Rate (SAR) Scanner System
ClinicalTrials.gov study NCT03331380. IPD Sharing: Not stated. Countries: 1. Publications: 4.
Clinical Trial on the Effects of Caffeine and Taurine From Energy Drinks (EDs) to Parameters of the Cardiovascular System in Humans
ClinicalTrials.gov study NCT01421979. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Growth Hormone's Effect on the Cardiovascular System
ClinicalTrials.gov study NCT00397319. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Prospective Follow-up, Marathon, Long Term, Inflammation and Cardiovascular System
ClinicalTrials.gov study NCT04166903. IPD Sharing: NO. Countries: 1. Publications: 2.
Noise, Oxidative Stress and Cardiovascular System
ClinicalTrials.gov study NCT06294340. IPD Sharing: NO. Countries: 1. Publications: 2.
Effects of Cross-sex Hormone Therapy on Eating Behavior, Metabolism, Energy Balance and Cardiovascular System
ClinicalTrials.gov study NCT04838249. IPD Sharing: YES. Countries: 1. Publications: 30.
Long-term Effects of Coronavirus Disease 2019 on the Cardiovascular System: CV COVID-19 Registry
ClinicalTrials.gov study NCT04359927. IPD Sharing: NO. Countries: 1. Publications: 4.
Usefulness of a Telemedicine System for OSA Patients Follow-up With High Cardiovascular Risk
ClinicalTrials.gov study NCT01226641. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Preventive Effects of Bosentan on the Systemic Cardiovascular Consequence of Sleep Apnea
ClinicalTrials.gov study NCT00777985. IPD Sharing: Not stated. Countries: 1. Publications: 1.
The Effect of Long-Term Moderate Intensity Exercise During Pregnancy on Maternal and Fetal Cardiovascular System
ClinicalTrials.gov study NCT06572943. IPD Sharing: Not stated. Countries: 1. Publications: 10.
Evaluation of Vascular Structure in Elderly Using High-frequency Ultrasound and Construction of a Multimodal Risk Assessment System for Cardiovascular Diseases: a Multicenter Study
ClinicalTrials.gov study NCT06221618. IPD Sharing: NO. Countries: 1. Publications: 3.
Beer, Marathon, Genetics, Inflammation and the Cardiovascular System: Be-MaGIC-Trial
ClinicalTrials.gov study NCT00933218. IPD Sharing: Not stated. Countries: 1. Publications: 5.
What is the Impact of Early Life Exposures on the Cardiovascular System in Young Adulthood?
ClinicalTrials.gov study NCT01487824. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Evaluation of Aging, Autonomic Nervous System Activity and Cardiovascular Events
ClinicalTrials.gov study NCT00759304. IPD Sharing: NO. Countries: 1. Publications: 35.
Subclinical Impairment of Cardiovascular System in Patients With Psoriasis
ClinicalTrials.gov study NCT05957120. IPD Sharing: Not stated. Countries: 1. Publications: 3.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.