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291 results for “carotid artery”
Hydrogen sulfide release via the ACE inhibitor Zofenopril prevents intimal hyperplasia in human vein segments and in a mouse model of carotid artery stenosis
<p>The current strategies to reduce intimal hyperplasia (IH) principally rely on local drug delivery, in endovascular approach. The oral angiotensin converting enzyme inhibitor (ACEi) Zofenopril has additional effects compared to other non-sulfyhydrated ACEi to prevent intimal hyperplasia and restenosis. Given the number of patients treated with ACEi worldwide, these findings call for further prospective clinical trials to test the benefits of sulfhydrated ACEi over classic ACEi for the prevention of restenosis in hypertensive patients.</p> <p>Abstract</p> <p>Objectives</p> <p>Hypertension is a major risk factor for intimal hyperplasia (IH) and restenosis following vascular and endovascular interventions. Pre-clinical studies suggest that hydrogen sulfide (H2S), an endogenous gasotransmitter, limits restenosis. While there is no clinically available pure H2S releasing compound, the sulfhydryl-containing angiotensin-converting enzyme inhibitor Zofenopril is a source of H2S. Here, we hypothesized that Zofenopril, due to H2S release, would be superior to other non-sulfhydryl containing angiotensin converting enzyme inhibitor (ACEi), in reducing intimal hyperplasia in the context of hypertension.</p> <p>Materials</p> <p>Spontaneously hypertensive male Cx40 deleted mice (Cx40-/-) or WT littermates were randomly treated with Enalapril 20 mg (Mepha Pharma) or Zofenopril 30 mg (Mylan SA). Discarded human vein segments and primary human smooth muscle cells (SMC) were treated with the active compound Enalaprilat or Zofenoprilat.</p> <p>Methods</p> <p>IH was evaluated in mice 28 days after focal carotid artery stenosis surgery and in human vein segments cultured for 7 days ex vivo. Human primary smooth muscle cell (SMC) proliferation and migration were studied in vitro.</p> <p>Results</p> <p>Compared to control animals (intima/media thickness=2.3±0.33), Enalapril reduced IH in Cx40-/- hypertensive mice by 30% (1.7±0.35; p=0.037), while Zofenopril abrogated IH (0.4±0.16; p<.0015 vs. Ctrl and p>0.99 vs. sham-operated Cx40-/-mice). In WT normotensive mice, enalapril had no effect (0.9665±0.2 in control vs 1.140±0.27; p>.99), while Zofenopril also abrogated IH (0.1623±0.07, p<.008 vs. Ctrl and p>0.99 vs. sham-operated WT mice). Zofenoprilat, but not Enalaprilat, also prevented intimal hyperplasia in human veins segments ex vivo. The effect of Zofenopril on carotid and SMC correlated with reduced SMC proliferation and migration. Zofenoprilat inhibited the MAPK and mTOR pathways in SMC and human vein segments.</p> <p>Conclusion</p> <p>Zofenopril provides extra beneficial effects compared to non-sulfhydryl ACEi to reduce SMC proliferation and restenosis, even in normotensive animals. These findings may hold broad clinical implications for patients suffering from vascular occlusive diseases and hypertension.</p>
Synchrotron-based visualization and segmentation of elastic lamellae in the mouse carotid artery during quasi-static pressure inflation: dataset
<p>This dataset contains images that were obtained during quasi-static pressure inflation of mouse carotid arteries. Images were taken with phase propagation imaging at the X02DA TOMCAT beamline of the Swiss Light Source synchrotron at the Paul Scherrer Institute in Villigen, Switzerland. Scans of n=12 left carotid arteries (n-6 Apoe-deficient mice, n=6 wild-type mice, all on a C57Bl6J background) were taken at pressure levels of 0, 10, 20, 30, 40, 50, 70, 90 and 120 mmHg. For analysis we selected 75 images from the center of each stack (starting at the center of the stack, and skipping 2 of every three images in both cranial and caudal axial directions) for each sample and for each pressure level, resulting in a total of 75 x 12 x 9 = 8100 analyzed images from 108 different scans. Segmentation, 3D visualization and geometric analysis is presented in the corresponding manuscript. Files are uploaded in 16bit .tif format and are named: mouseid_pressurelevel_stacknumber, with mouseid consisting of either Apoe (Apoe-deficient) or Bl (wild-type) and the mouse number, pressurelevel varies from P0 to P120 and stacknumber indicates which image from the stack has been uploaded.</p>
Synchrotron-based visualization and segmentation of elastic lamellae in the mouse carotid artery during quasi-static pressure inflation: 2D segmentations
<p>This dataset contains 2D segmentations of images that were obtained during quasi-static pressure inflation of mouse carotid arteries. Images were taken with phase propagation imaging at the X02DA TOMCAT beamline of the Swiss Light Source synchrotron at the Paul Scherrer Institute in Villigen, Switzerland. Scans of n=12 left carotid arteries (n-6 Apoe-deficient mice, n=6 wild-type mice, all on a C57Bl6J background) were taken at pressure levels of 0, 10, 20, 30, 40, 50, 70, 90 and 120 mmHg. For analysis we selected 75 images from the center of each stack (starting at the center of the stack, and skipping 2 of every three images in both cranial and caudal axial directions) for each sample and for each pressure level, resulting in a total of 75 x 12 x 9 = 8100 analyzed images from 108 different scans. Segmentation algorithm, 3D visualization and geometric analysis are presented in the corresponding manuscript. Files are uploaded in .jpg format and are named: lamella_slicenumber, with slicenumber varying from 1 to 8100. There is also a Matlab file, UndulationData_Zenodo.mat, in which all the relevant variables post analysis are stored. This file contains a variable called "myFiles", which contains the link between the slicenumbers used here and the original dataset that is published in Zenodo (.tif synchrotron images).</p>
Text-fig. 4. Metacheiromys marshii, AMNH 131777, basicranial isosurface from CT scans in oblique posteroventral view: left petrosal in blue and small piece of left entotympanic in red. The white arrow on the left petrosal passes through a canal traversed by the tympanic nerve. Abbreviations: abX – foramen for auricular branch of vagus nerve, aptt – anteroventral process of tegmen tympani, as – alisphenoid, bo – basioccipital, bs – basisphenoid, ctp – caudal tympanic process, eam – squamosal roof of external acoustic meatus, ec – ectotympanic, en – entotympanic, eo – exoccipital, hf – hypoglossal foramen, ips – foramen for inferior petrosal sinus, ljf – lateral jugular foramen, me – mastoid exposure of petrosal, mjf – medial jugular foramen, mt – muscular tubercle, oc – occipital condyle, pcf – posterior carotid foramen, pp – paroccipital process of petrosal, pr – promontorium of petrosal, ptp – posttympanic process of squamosal, smf – stylomastoid foramen, sq – squamosal, stf – stapedial artery foramen, tca – tympanic canaliculus, th – tympanohyal. in Skeletal Anatomy Of The Basicranium And Auditory Region In The Metacheiromyid Palaeanodont Metacheiromys (Mammalia, Pholidotamorpha) Based On High-Resolution Ct Scans
Text-fig. 4. Metacheiromys marshii, AMNH 131777, basicranial isosurface from CT scans in oblique posteroventral view: left petrosal in blue and small piece of left entotympanic in red. The white arrow on the left petrosal passes through a canal traversed by the tympanic nerve. Abbreviations: abX – foramen for auricular branch of vagus nerve, aptt – anteroventral process of tegmen tympani, as – alisphenoid, bo – basioccipital, bs – basisphenoid, ctp – caudal tympanic process, eam – squamosal roof of external acoustic meatus, ec – ectotympanic, en – entotympanic, eo – exoccipital, hf – hypoglossal foramen, ips – foramen for inferior petrosal sinus, ljf – lateral jugular foramen, me – mastoid exposure of petrosal, mjf – medial jugular foramen, mt – muscular tubercle, oc – occipital condyle, pcf – posterior carotid foramen, pp – paroccipital process of petrosal, pr – promontorium of petrosal, ptp – posttympanic process of squamosal, smf – stylomastoid foramen, sq – squamosal, stf – stapedial artery foramen, tca – tympanic canaliculus, th – tympanohyal.
Auditory region circulation in Lagomorpha: the internal carotid artery pattern revisited
<p>The internal carotid artery (ICA) is one of the major vessels in the cranial circulation. Characters concerning the ICA, such as its course in the auditory region, have been employed frequently in phylogenetic analyses of mammals, including extinct taxa. In lagomorphs, however, our knowledge on vascular features of the auditory region has been based predominantly on living species, mostly on the European rabbit. We present the first survey on 11 out of 12 extant genera and key fossil taxa such as stem lagomorphs and early crown representatives (<em>Archaeolagus</em> and <em>Prolagus</em>). The ICA pattern shows a modified transpromontorial course in stem taxa (<em>Litolagus</em>, <em>Megalagus</em> and <em>Palaeolagus</em>) and <em>Archaeolagus</em>, which we propose as the ancestral character state for Lagomorpha, similar to that for the earliest rodents, plesiadapids and scandentians. The ICA pattern in leporids is perbullar but shows structural similarities to stem taxa, whereas the extrabullar ICA course in Ochotona is apparently a highly derived condition. <em>Prolagus</em> shows a mixed character state between leporids and Ochotona in its ICA route. The persistence of the transpromontorial ICA course and similarities in the carotid canal structure among stem taxa and crown leporids support morphological conservatism in Lagomorpha, in contrast to their sister clade Rodentia.</p>
Protective Effects of Long-term Remote Limb Ischemic Preconditioning For Carotid Artery Stenting
ClinicalTrials.gov study NCT01654666. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Bovine Carotid Artery Biologic Graft and Expanded Polytetrafluoroethylene for Permanent Hemodialysis Access
ClinicalTrials.gov study NCT03300024. IPD Sharing: NO. Countries: 1. Publications: 1.
Additional Neurological Symptoms Before Surgery of the Carotid Arteries - A Prospective Study (ANSYSCAP)
ClinicalTrials.gov study NCT00514592. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Safety and Efficacy Study for Reverse Flow Used During Carotid Artery Stenting Procedure
ClinicalTrials.gov study NCT01685567. IPD Sharing: Not stated. Countries: 2. Publications: 4.
Optical Coherence Tomography Angiography Evaluation of Ocular Changes in Patients With Carotid Artery Stenosis
ClinicalTrials.gov study NCT04326842. IPD Sharing: UNDECIDED. Countries: 1. Publications: 1.
Safety and Performance Evaluation of WIRION™ EPD in Patients Undergoing Carotid Artery Stenting
ClinicalTrials.gov study NCT01783639. IPD Sharing: Not stated. Countries: 3. Publications: 1.
Comparison Of The Effects Of Regional Anesthesia On Brain And Carotid Artery Oxygenation In Shoulder Surgery
ClinicalTrials.gov study NCT07398352. IPD Sharing: NO. Countries: 0. Publications: 3.
POST-APPROVAL STUDY of TRANSCAROTID ARTERY REVASCULARIZATION in PATIENTS With SIGNIFICANT CAROTID ARTERY DISEASE
ClinicalTrials.gov study NCT02536378. IPD Sharing: Not stated. Countries: 3. Publications: 4.
Evaluate Carotid Artery Plaque Composition by Magnetic Resonance Imaging in People Receiving Cholesterol Medication
ClinicalTrials.gov study NCT00715273. IPD Sharing: NO. Countries: 1. Publications: 12.
Auditory region circulation in Lagomorpha: the internal carotid artery pattern revisited
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Data from: An uncommon cause of carotid artery dissection: Fabry disease.
<p>Internal cervical artery dissection represent a common etiology of stroke in the young, while the most common central nervous system manifestation of Fabry Disease (FD) is acute cerebral ischemia. Nevertheless, internal carotid artery disease has been scarcely associated with Fabry Disease. </p> <p>We describe the neuroimaging findings of an 49-year-old patient presenting with acute left middle cerebral artery occlusion due to an underlying internal carotid artery dissection. The patient was successfully treated with intravenous thrombolysis and mechanical thrombectomy. Further diagnostic work-up revealed bilateral cornea verticillata and large-fiber polyneuropathy with impaired cold and warm perception. Low a-galactosidase levels and molecular genetic testing established the diagnosis of Fabry Disease, while the patient was started on oral chaperone therapy with migalastat. </p> <p>The present case highlights that Fabry Disease may occasionally manifest with internal carotid artery dissection and that FD should be included in the diagnostic work-up of spontaneous internal carotid artery dissection. <br> </p>
Feasibility Study of Phase-contrast MRI for Flow in the External Carotid Branches Arteries
ClinicalTrials.gov study NCT02829190. IPD Sharing: Not stated. Countries: 1. Publications: 19.
PET-MRI Imaging in Patients With Symptomatic Carotid Artery Stenosis
ClinicalTrials.gov study NCT03215550. IPD Sharing: NO. Countries: 1. Publications: 1.
The Carotid Artery Multi-modality Imaging Prognostic (CAMP) Study
ClinicalTrials.gov study NCT04679727. IPD Sharing: Not stated. Countries: 1. Publications: 9.
Perioperative Time Course of MMP-9 and Its Inhibitor During Carotid Artery Stenting and Carotid Endarterectomy
ClinicalTrials.gov study NCT03410576. IPD Sharing: NO. Countries: 1. Publications: 2.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.