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131 results for “carotid plaque”
Asymptomatic Carotid Stenosis: Cognitive Function and Plaque Correlates
ClinicalTrials.gov study NCT01353196. IPD Sharing: NO. Countries: 1. Publications: 1.
Evaluate Carotid Artery Plaque Composition by Magnetic Resonance Imaging in People Receiving Cholesterol Medication
ClinicalTrials.gov study NCT00715273. IPD Sharing: NO. Countries: 1. Publications: 12.
Imaging of the vulnerable carotid plaque – current role of imaging techniques and a research agenda
<p><b>Objectives:</b> Atherothrombosis in the carotid arteries is a main cause of ischemic stroke, and may depend on plaque propensity to complicate with rupture or erosion, in turn related to qualitative features amenable to in vivo imaging. This would provide an opportunity for risk stratification and – potentially – local treatment of more "vulnerable" plaques. We here review current information on this topic.</p> <p><b>Methods:</b> We systematically reviewed the literature for concepts derived from pathophysiological, histopathological and clinical studies on imaging techniques attempting at identifying vulnerable carotid lesions.</p> <p><b>Results:</b> Magnetic resonance imaging, computed tomography, ultrasound- and nuclear medicine-based techniques, alone or with multimodality approaches, all have a link to pathophysiology, and describe different – potentially complementary – aspects of lesions prone to complication. There is also, however, a true paucity of head-to-head comparisons of such techniques for practical implementation of a thorough and cost-effective diagnostic strategy. Especially in asymptomatic patients, major international societies leave wide margins of indecision in the advice to techniques guiding interventions to prevent atherothrombotic stroke.</p> <p><b>Conclusions:</b> To improve practical management of such patients – in addition to patient's vulnerability for systemic reasons – a more precise identification of the vulnerable plaque is needed. A better definition of the diagnostic yield of each imaging approach in comparison with the others should be pursued for a cost-effective translation of the single techniques. Practical translation to guide future clinical practice should be based on improved knowledge of the specific pathophysiologic correlates and on a comparative modality approach, linked to subsequent stroke outcomes.</p>
A Dataset of Reconstructed Carotid Bifurcation Lumen and Plaque Models with Centerline Tree and Simulated Hemodynamics
<p><code>carotid_bifurcation_database.zip</code> contains 79 cases of left and right-side carotid bifurcations (152 inner wall models). For each case, inner wall (lumen) and plaque models were extracted from computed tomography angiography (CTA) scans. The models were segmented, reconstructed, and a centerline tree was created for each geometry using the <a href="https://github.com/PepeEulzer/CarotidAnalyzer">CarotidAnalyzer</a> pipeline. The geometries include varying degrees of internal carotid stenosis. Bifurcations with 100% stenosis were omitted, as the vessel is not discernible in the scan.</p> <p><code>carotid_flow_database.zip</code> contains hemodynamic flow simulations of the above models. Fluid data (velocity, pressure) and surface data (wall shear stress) are given in seperate files for each case. For each field, a systolic and diastolic time step are provided.</p> <p><strong>Further information regarding the extraction pipeline and flow simulations can be obtained from the following publications:<br></strong>P. Eulzer, F. von Deylen, W.-C. Hsu, R. Wickenhöfer, C. M. Klingner, and K. Lawonn (2023), A Fully Integrated Pipeline for Visual Carotid Morphology Analysis. Computer Graphics Forum, 42(3): 25-37. <a href="https://doi.org/10.1111/cgf.14808">https://doi.org/10.1111/cgf.14808</a></p> <p>Kevin Richter, Tristan Probst, Anna Hundertmark, Pepe Eulzer, and Kai Lawonn (2024), Longitudinal wall shear stress evaluation using centerline projection approach in the numerical simulations of the patient-based carotid artery. Computer Methods in Biomechanics and Biomedical Engineering, 27(3): 347-364. <a href="https://doi.org/10.1080/10255842.2023.2185478">https://doi.org/10.1080/10255842.2023.2185478</a></p> <p>P. Eulzer, K. Richter, A. Hundertmark, R. Wickenhöfer, C. M. Klingner, and K. Lawonn (2024), Instantaneous Visual Analysis of Blood Flow in Stenoses Using Morphological Similarity. Computer Graphics Forum 43(3): in print. <a href="https://doi.org/10.1111/cgf.15081">https://doi.org/10.1111/cgf.15081</a></p>
Norwegian Carotid Plaque Study
ClinicalTrials.gov study NCT02759653. IPD Sharing: Not stated. Countries: 1. Publications: 1.
The Changes in Carotid Plaque Neovascularization After Elovocumab Therapy
ClinicalTrials.gov study NCT04423406. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Carotid Plaque Burden in Patients With Philadelphia Negative Myeloproliferative Neoplasms
ClinicalTrials.gov study NCT05993052. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Influenza A VIRus and Destabilization of Atherosclerotic Carotid Plaques
ClinicalTrials.gov study NCT06217471. IPD Sharing: UNDECIDED. Countries: 1. Publications: 6.
Use of in Vivo 3T MR to Characterize Carotid Plaque in Patients and Correlate MR Findings With Symptoms
ClinicalTrials.gov study NCT02335567. IPD Sharing: Not stated. Countries: 1. Publications: 8.
Spider Versus Emboshield Distal Protection on Cerebral Microembolization During Vulnerable Plaque in Carotid Artery Stenting
ClinicalTrials.gov study NCT04904250. IPD Sharing: NO. Countries: 1. Publications: 0.
Arachidonic Acid Metabolism in Carotid Stenosis Plaque in Diabetic Patients
ClinicalTrials.gov study NCT03202823. IPD Sharing: Not stated. Countries: 1. Publications: 1.
A Trial to Evaluate the Efficacy and Safety of DR10624 in Patients With Hypertriglyceridemia and Carotid Atherosclerotic Plaque
ClinicalTrials.gov study NCT07050134. IPD Sharing: NO. Countries: 1. Publications: 7.
Histological Validation Of Carotid Plaque Composition In Preoperative Imaging
ClinicalTrials.gov study NCT01456403. IPD Sharing: NO. Countries: 1. Publications: 1.
Carotid Plaque Imaging in Acute Stroke
ClinicalTrials.gov study NCT01284933. IPD Sharing: Not stated. Countries: 1. Publications: 5.
Intelligent Detection of Carotid Plaque and Its Stability Based on Deep Learning Dynamic Ultrasound Scanning
ClinicalTrials.gov study NCT05230576. IPD Sharing: NO. Countries: 1. Publications: 7.
Individualized Physical Activity and Carotid Plaque Instability
ClinicalTrials.gov study NCT04053166. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Classification of Carotid Plaque With Computed Tomography With Fast kVp (Kilovolt Peak)-Switching Technique
ClinicalTrials.gov study NCT02436967. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Comparison of Fimasartan Versus Amlodipine Therapy on Carotid PlaquE Inflammation
ClinicalTrials.gov study NCT02378064. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Carotid Plaque Assessment Using 18Fluorine (18F) -Sodium Fluoride Positron Emission Tomography (PET) /MR
ClinicalTrials.gov study NCT02726984. IPD Sharing: NO. Countries: 1. Publications: 1.
Omacor and Placebo in Carotid Plaque Stability
ClinicalTrials.gov study NCT00294216. IPD Sharing: Not stated. Countries: 1. Publications: 2.
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
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International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.