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20 results for “caspase-3”
Figure 3. Negative Caspase-3 in Investigation of protective effects of lithium borate on spermatogenesis and testes histopathology against cadmium-induced acute toxicity in rats
Figure 3. Negative Caspase-3 expressions in testes tissues of control and LTB groups (A and C), severe Caspase-3 expression in spermatocytes of Cd group (arrowheads) (B), mild Caspase- 3 expression in spermatocytes (arrowheads) of LTB + Cd group (D), IHC - P, Bar: 20 µm.
Catalysis of Ac-DEVD-AMC by caspase-3 (dataset formatted for analysis by interferENZY)
<p><strong>Main description</strong></p> <p>This dataset depicts the catalysis of the fluorogenic substrate Ac-DEVD-AMC to the fluorescent substrate AMC by recombinant purified caspase-3, for fixed concentration of enzyme and variation of concentration of initial substrate. It was originally documented in <em>Biophysical Chemistry 252 (2019) 106193</em> (<a href="https://doi.org/10.1016/j.bpc.2019.106193">https://doi.org/10.1016/j.bpc.2019.106193</a>), and then used as a study case for the webserver interferENZY (a web-based tool for enzymatic assay validation and standardized kinetic analysis; visit <a href="https://interferenzy.i3s.up.pt">https://interferenzy.i3s.up.pt</a> for more information). To this end, it was converted to the format here presented: tab-separated *.txt input required for interferENZY analysis.</p> <p> </p> <p><strong>Dataset organization</strong></p> <p>Line 1: Tab-separated initial concentrations of substrate Ac-DEVD-AMC in micromolar (µM) concentration</p> <p>Line 2: Concentration of enzyme (1 U)</p> <p>Line 3: Units of time</p> <p>Line 4: Units of concentration for substrate values and measurements</p> <p>Line 5: Dataset name</p> <p>Line 6 and downwards: Tab-separated column-pairs of the progress curves (time,Product) corresponding to the indicated values of initial concentrations of substrate in line 1</p> <p> </p> <p><strong>Contact information:</strong></p> <p>Maria Filipa Pinto (mfpinto@i3s.up.pt)<br> Pedro M. Martins (pmartins@ibmc.up.pt)</p> <p>i3S – Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Rua Alfredo Allen, 208, 4200-135 Porto, Portugal. Telephone number: +351 226 074 900</p>
Molecular dynamics simulations data of Caspase-3 enzyme with pentapeptide ligand DEVDG and its chiral mutant DEVdG having D-Asp at fourth position
<p>Amino acids in proteins are maintained in one specific L chiral form in the body. D-amino acids are not normally incorporated into proteins and their accumulation has been associated with several conditions including schizophrenia, amyotrophic lateral sclerosis, and other age-related disorders. However, the mechanisms by which the accumulation of D-amino-acids in proteins may lead to pathophysiological consequences remain poorly understood. In this work, we studied a model protease system, caspase-3 that specifically hydrolyses the 4’–5’ peptide bond of the pentapeptide substrate DEVDG. Through extensive molecular dynamics simulations, free energy calculations and distance maps, we reveal that caspase-3 naturally rejects the pentapeptide containing D-Asp substrate, DEVdG and prevents catalytic activity by caspase. The importance of this chiral discriminating capacity is evident from chiral-selective in vivo experimental assays to detect caspase-bound D-Asp in Drosophila where altering the chiral balance created impaired caspase activity and impaired apoptosis, increased tumour formation, and premature death. The modelling data reveals the molecular level charge balancing that enforces the chiral recognition necessary to maintain homeostasis across the cell, tissue, and organ level.</p>
Evaluation of Mucoadhesive Tacrolimus Patch on Caspase-3 Inducing Apoptosis in Oral Lichen Planus
ClinicalTrials.gov study NCT05139667. IPD Sharing: UNDECIDED. Countries: 1. Publications: 1.
Atypical contribution of caspase-3 to melanoma cancer cell motility by regulating coronin-1B activity
GEO Series GSE270452. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
Transcriptome analysis of Caspase-3 inhibited or not MDA-MB-231 tumors after docetaxel treatment
GEO Series GSE87226. Homo sapiens. 4 samples. Type: Expression profiling by high throughput sequencing.
Functional genomics of Caspase-3 deficiency or proficiency in MCF-7 cells or MDA-MB-231 tumors after docetaxel treatment
GEO Series GSE87227. Homo sapiens. 12 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing.
Interaction between cyclooxygenase-2 and caspase-3 abolishes the cleavage of RNA-binding protein HuR and promotes drug resistance in oral squamous cell carcinoma
GEO Series GSE79477. Homo sapiens. 4 samples. Type: Expression profiling by high throughput sequencing.
Transcriptome analysis of Caspase-3 deficient and proficient MCF-7 cells after docetaxel exposure
GEO Series GSE87225. Homo sapiens. 4 samples. Type: Expression profiling by high throughput sequencing.
A novel non-nad-based PARP1 inhibitor, Japoflavone B, triggered Caspase-3/GSDME-mediated pyroptosis through ROS/p38/p53 pathway in NSCLC
GEO Series GSE281636. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
Effect of caspase-3 and -7 knockout on doxorubicin treated B16 melanoma cells
GEO Series GSE210377. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
Analyses of CED-3 caspase and PMK-1 p38 MAPK in gene regulation in C elegans
GEO Series GSE145983. Caenorhabditis elegans. 12 samples. Type: Expression profiling by high throughput sequencing.
Expression data from heart muscle of cardiac-specific caspase-3 and -7 knockout and wild type newborn and young mice
GEO Series GSE63023. Mus musculus. 24 samples. Type: Expression profiling by array.
MicroRNA-124 and -137 cooperativity controls caspase-3 activity through BCL2L13 in hippocampal neural stem cells. [RNA expression]
GEO Series GSE79129. Mus musculus. 6 samples. Type: Expression profiling by array.
Loss of executioner caspases-3 and -7 in intestinal epithelial cells is dispensable but can be compensated allowing normal gut homeostasis
GEO Series GSE183887. Mus musculus. 24 samples. Type: Expression profiling by high throughput sequencing.
Proteinase 3 Drives Murine Diabetic Kidney Disease by Mediating Caspase-3-dependent Apoptosis of Podocytes
GEO Series GSE220631. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
Functional analysis of caspase cleavable proteoforms of the Drosophila GSK-3 gene shaggy.
GEO Series GSE157625. Drosophila melanogaster. 6 samples. Type: Expression profiling by high throughput sequencing.
Anti-PD-1 exacerbates bleomycin-induced lung injury in mice via Caspase-3/GSDME-mediated pyroptosis
GEO Series GSE280068. Mus musculus. 9 samples. Type: Non-coding RNA profiling by high throughput sequencing.
MicroRNA-124 and -137 cooperativity controls caspase-3 activity through BCL2L13 in hippocampal neural stem cells. [miRNA expression]
GEO Series GSE79131. Mus musculus. 6 samples. Type: Expression profiling by RT-PCR.
MicroRNA-124 and -137 cooperativity controls caspase-3 activity through BCL2L13 in hippocampal neural stem cells.
GEO Series GSE79132. Mus musculus. 12 samples. Type: Expression profiling by array; Expression profiling by RT-PCR.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.