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2,088 results for “catheter”
A Niclosamide-releasing hot-melt extruded catheter prevents Staphylococcus aureus experimental biomaterial-associated infection
<p>Biomaterial-associated infections are a major healthcare challenge as they are responsible for high disease burden in critically ill patients. In this study, we have developed drug-eluting antibacterial catheters to prevent catheter-related infections. Niclosamide (NIC), originally an antiparasitic drug, was incorporated into the polymeric matrix of thermoplastic polyurethane (TPU) via solvent casting, and catheters were fabricated using hot-melt extrusion technology. The mechanical and physicochemical properties of TPU polymers loaded with NIC were studied. NIC was released in a sustained manner from the catheters and exhibited <em>in vitro</em> antibacterial activity against <em>Staphylococcus aureus</em> and <em>Staphylococcus epidermidis</em>. Moreover, the antibacterial efficacy of NIC-loaded catheters was validated in an <em>in vivo</em> biomaterial-associated infection mouse model using a methicillin-susceptible and methicillin-resistant strain of <em>S. aureus. </em>The released NIC from the produced catheters reduced bacterial colonization of the catheter as well as of the surrounding tissue. In summary, the NIC-releasing hot-melt extruded catheters prevented implant colonization and reduced the bacterial colonization of peri-catheter tissue by methicillin sensitive as well as resistant <em>S. aureus</em> in a biomaterial-associated infection mouse model and has good prospects for preclinical development.</p>
Edoxaban Treatment Versus Vitamin K Antagonist (VKA) in Patients With Atrial Fibrillation (AF) Undergoing Catheter Ablation
ClinicalTrials.gov study NCT02942576. IPD Sharing: YES. Countries: 11. Publications: 10.
Edoxaban Compared to Standard Care After Heart Valve Replacement Using a Catheter in Patients With Atrial Fibrillation (ENVISAGE-TAVI AF)
ClinicalTrials.gov study NCT02943785. IPD Sharing: YES. Countries: 14. Publications: 5.
Enterobacter cloacae complex (E. bugandensis species, ST599) strain associated with a catheter-related bloodstream infection (CRBSI) (genome assembly and annotation dataset)
<p>This dataset includes the assembled contigs (.fasta and .gbk files), the nucleotide sequences of the prediction transcripts (.ffn files) and the respective amino acid sequences of the translated CDS sequences (.faa files) of a <em><strong>Enterobacter cloacae </strong></em><strong>complex</strong><em><strong> (E. bugandensis </strong></em><strong>species</strong><em><strong>, </strong></em><strong>ST599</strong><em><strong>) </strong></em>strain associated with a catheter-related bloodstream infection (CRBSI) (genome anotation was performed using Prokka v1.14.5; https://github.com/tseemann/prokka)</p> <p>The raw sequence reads were deposited in the European Nucleotide Archive (ENA) (BioProject PRJEB45360; Run Accession: ERR10044433).</p>
Comparative analysis of two Candida parapsilosis isolates from the patient with a central venous catheter harbouring the Y132F and R398I mutations
<p>This work presents a comparative analysis of 2 clinical isolates of <em>C. parapsilosis</em>; isolated from haemoculture (HC) and central venous catheter (CVC). Both strains harboured Y132F and R398I mutations associated with resistance to fluconazole (FLC). Differences between HC and CVC isolates in terms of virulence, resistance to FLC and lipid distribution were addressed. Expression of the ERG6 and ERG9 genes, lipid analysis, fatty acid composition and lipase activity were assessed by qPCR, thin-layer chromatography/high performance liquid chromatography, gas chromatography and spectrophotometry, respectively. A regulation of the ERG6 and ERG9 genes did not prove any impact on FLC resistance. Analysis of lipid metabolism showed a higher accumulation of lanosterol in both isolates regardless of FLC presence. Additionally, a decreased level in triacylglycerols (TAG) with impact on the composition of total FA was observed for both isolates. Direct impact of the ERG11 mutations to lipid/FA analysis has not been confirmed. The higher lipase activity observed for <em>C. parapsilosis</em> HC isolate could be correlated with the significantly decreased level of TAG. The very close relatedness between both isolates suggests that one isolate was derived from another after the initial infection of the host.</p>
Use of Dapagliflozin to Reduce Burden of Atrial Fibrillation in Patients Undergoing Catheter Ablation of Symptomatic Atrial Fibrillation
ClinicalTrials.gov study NCT04792190. IPD Sharing: NO. Countries: 1. Publications: 42.
Randomized Controlled Trial of Talc Instillation In Addition To Daily Drainage Through a Tunneled Pleural Catheter to Improve Rates of Outpatient Pleurodesis in Patients With Malignant Pleural Effusio
ClinicalTrials.gov study NCT04792970. IPD Sharing: NO. Countries: 1. Publications: 2.
Pan-Asia United States PrEvention of Sudden Cardiac Death Catheter Ablation Trial
ClinicalTrials.gov study NCT02848781. IPD Sharing: NO. Countries: 5. Publications: 2.
Liposomal Bupivacaine vs Continuous Nerve Catheters for Below the Knee Amputations
ClinicalTrials.gov study NCT05140499. IPD Sharing: NO. Countries: 1. Publications: 21.
A Study Assessing Arrhythmia Mapping With the Multi-Electrode OPTRELL™ Mapping Catheter
ClinicalTrials.gov study NCT04983797. IPD Sharing: YES. Countries: 2. Publications: 14.
Pilot Study of the Safety of a Daily Ethanol Lock for Urinary Catheters in Critically Ill Children
ClinicalTrials.gov study NCT01865708. IPD Sharing: NO. Countries: 1. Publications: 1.
An Initial Assessment of the Sphere-9™ Catheter and Affera Mapping and Ablation System
ClinicalTrials.gov study NCT04210622. IPD Sharing: NO. Countries: 1. Publications: 2.
Single Catheter Primary Percutaneous Coronary Intervention Method in Patients With ST Elevation Myocardial Infarction
ClinicalTrials.gov study NCT05604976. IPD Sharing: NO. Countries: 1. Publications: 7.
Comparing Peripherally Inserted Central Catheters to Long Peripheral Catheters in Pediatrics
ClinicalTrials.gov study NCT05346406. IPD Sharing: NO. Countries: 1. Publications: 12.
Study of Safety and Efficacy for the Eustachian Tube Balloon Catheter
ClinicalTrials.gov study NCT02087150. IPD Sharing: YES. Countries: 1. Publications: 1.
A Study Exploring Two Treatment Strategies in Patients With Atrial Fibrillation Who Undergo Catheter Ablation Therapy
ClinicalTrials.gov study NCT01729871. IPD Sharing: Not stated. Countries: 5. Publications: 1.
Study to Estimate the Point Prevalence of Peripheral Intravenous Catheter-related Complications in Brazil
ClinicalTrials.gov study NCT03719287. IPD Sharing: Not stated. Countries: 1. Publications: 11.
First - In - Man Study to Assess the Safety and Feasibility of The Bashir™ Endovascular Catheter for the Treatment of Acute Pulmonary Embolism
ClinicalTrials.gov study NCT03927508. IPD Sharing: NO. Countries: 1. Publications: 1.
A Study For Treatment Of Paroxysmal Atrial Fibrillation (PAF) With The THERMOCOOL SMARTTOUCH SF Catheter and TRUPULSE Generator
ClinicalTrials.gov study NCT05752487. IPD Sharing: YES. Countries: 4. Publications: 2.
Multi-electrode Radiofrequency Balloon Catheter Use for the Isolation of the Pulmonary Veins.
ClinicalTrials.gov study NCT03437733. IPD Sharing: Not stated. Countries: 3. Publications: 1.
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OpenNeuro
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