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Dataset results
522 results for “cell expansion”
Data from: Cellects, a software to quantify cell expansion and motion
<p>Automated quantification offers unique opportunities to study biological phenomena, increasing reproducibility, replicability, accuracy, and throughput, while reducing observer biases. We present Cellects, a tool to quantify growth and motion in 2D. This software operates with image sequences containing specimens growing and moving on an immobile flat surface. Its user-friendly interface makes it easy to adjust the quantification parameters to cover a wide range of species and conditions, and includes tools to validate the results and correct mistakes if necessary. The software provides the region covered by the specimens at each point of time, as well as many geometrical descriptors that characterize it. We validated Cellects with <em>Physarum polycephalum</em>, which is particularly difficult to detect because of its complex shape and internal heterogeneity. This validation covered five different conditions with different background and lighting, and found Cellects to be highly accurate in all cases. Cellects' main strengths are its broad scope of action, automated computation of a variety of geometrical descriptors, easy installation and user-friendly interface.</p>
Data used in the study "mRNA vaccination boosts spike-specific T cell memory and promotes expansion of CD45RAint TEMRA-like CD8+ T cells in COVID-19 recovered individuals"
<p>Data associated with an original research study examining T cell responses to mRNA vaccination in COVID-19 recovered individuals. 10X Cell Ranger outputs, bulk TCR sequencing data, and T cell functional (ICS) data in this study have been deposited. Authors KMB and HR contributed equally to this effort. Address correspondence to EWN.</p>
Data from: Cellects, a software to quantify cell expansion and motion
Open the record for dataset details and reuse information.
Sustained liver HBsAg loss and clonal T and B cell expansion upon therapeutic DNA vaccination require low HBsAg levels
<p>C57BL/6 mice samples transduced with AAV-HBV, followed by treatment with siRNA+TxTv, control siRNA+TxVx or control siRNA+empty plasmid. 10x genomics (VDJ) was performed in liver IHIC.</p><p>An rds object with the raw and normalised counts, the annotations is available.</p>
Dataset for "Role of electron-phonon coupling and thermal expansion on band gaps, carrier mobility, and interfacial offsets in kesterite thin-film solar cells"
<p>Dataset for "Role of electron-phonon coupling and thermal expansion on band gaps, carrier mobility, and interfacial offsets in kesterite thin-film solar cells"</p>
Preservation and Expansion of T-cell Subsets Following HAART De-intensification to Atazanavir/Ritonavir (ATV/r)
ClinicalTrials.gov study NCT00491556. IPD Sharing: Not stated. Countries: 2. Publications: 1.
Dose Escalation and Dose Expansion Study of Tirabrutinib in Combination With Other Targeted Anti-cancer Therapies in Adults With B-cell Malignancies
ClinicalTrials.gov study NCT02457598. IPD Sharing: NO. Countries: 3. Publications: 6.
A Pilot Study of Autologous T-Cell Transplantation With Vaccine Driven Expansion of Anti-Tumor Effectors After Cytoreductive Therapy in Metastatic Pediatric Sarcomas
ClinicalTrials.gov study NCT00001566. IPD Sharing: Not stated. Countries: 1. Publications: 5.
A Phase Ib Expansion Study Investigating the Safety, Efficacy, and Pharmacokinetics of Intravenous CUDC-101 in Subjects With Advanced Head and Neck, Gastric, Breast, Liver and Non-small Cell Lung Canc
ClinicalTrials.gov study NCT01171924. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Ph1b/2 Dose-Escalation Study of Entinostat With Pembrolizumab in Non-small Cell Lung Cancer (NSCLC) With Expansion Cohorts in NSCLC, Melanoma, and Colorectal Cancer (CRC)
ClinicalTrials.gov study NCT02437136. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Interleukin-7 (CYT107) Treatment of Idiopathic CD4 Lymphocytopenia: Expansion of CD4 T Cells (ICICLE)
ClinicalTrials.gov study NCT00839436. IPD Sharing: Not stated. Countries: 1. Publications: 4.
Gluten-free diet exposure prohibits pathobiont expansion and gluten sensitive enteropathy in B cell deficient mice
<p>In humans, celiac disease (CeD) is a T-cell-driven gluten-sensitive enteropathy (GSE) localized to the small bowel (duodenum). The presence of antibodies specific for gluten- and self-antigens are commonly used diagnostic biomarkers of CeD and are considered to play a role in GSE pathogenesis. Previously, we have described an apparent T-cell-mediated GSE in CD19<sup>-/-</sup> mice, which develop weak and abnormal B cell responses. Here, we expand on this observation and use a mouse model of complete B cell deficiency (J<sub>H</sub><sup>-/-</sup> mice), to show that absence of a humoral immune response also promotes development of a GSE. Furthermore, 16S analysis of microbial communities in the small intestine (SI) demonstrates that a gluten-free diet (GFD) suppresses the expansion of anaerobic bacteria in the SI and colonization of the SI by a specific pathobiont. Finally, we also observe that SI enteropathy in mice fed a gluten-rich diet (GRD) is positively correlated with the abundance of several microbial peptidase genes, which supports that bacterial metabolism of gluten may be an important driver of GSE in our model. Collectively, results from our experiments indicate that J<sub>H</sub><sup>-/-</sup> mice will be a useful resource to investigators seeking to empirically delineate the contribution of humoral immunity on GSE pathogenesis, and support the hypothesis that humoral immunity promotes tolerance to gluten.</p>
Benchmark datasets for "Detecting T-cell expansion and quantifying clone survival from deep profiling of immune repertoires"
<p>T-cell receptor repertoire sequencing datasets describing time courses obtained for vaccination, normal aging and blood transplant cases. Datasets reported here were previously published (except for Tem/Tcm data), this is just a compendium of selected samples that is properly pre-processed and formatted.</p>
Ongoing Effect of Expansion Prisms Following the Discontinuation of Use on Visual Field Enlargement and Retrograde Ganglion Cell Degeneration in Homonymous Hemianopia Patients
ClinicalTrials.gov study NCT06674369. IPD Sharing: YES. Countries: 1. Publications: 1.
Autologous ex Vivo Conjunctival Epithelial Cell Expansion for Ocular Surface Transplantation
ClinicalTrials.gov study NCT00346450. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Cord Blood Expansion on Mesenchymal Stem Cells
ClinicalTrials.gov study NCT00498316. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Autologous T-Cell Transplantation and the Immunotherapy of Residual Disease in Breast Cancer: Pilot Study of Vaccine-Driven T-Cell Expansion in Patients Treated With Dose-Intensive Chemotherapy
ClinicalTrials.gov study NCT00001440. IPD Sharing: Not stated. Countries: 1. Publications: 3.
Autologous Bone Marrow-Derived Mononuclear Cell Transplantation in Accelerating Tissue Expansion and Skin Regeneration
ClinicalTrials.gov study NCT01209611. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Gluten-free diet exposure prohibits pathobiont expansion and gluten sensitive enteropathy in B cell deficient mice
Open the record for dataset details and reuse information.
Integrative analyses of single-cell transcriptome and immune profiling reveal clonal expansion of T cells in the blood and cerebrospinal fluid of Parkinson's disease
<p>An increasing number of studies has indicated that the immune system plays important roles in the pathogenesis of Parkinson's disease. However, little is known about the contribution of adaptive immune responses in Parkinson's disease. Here, we performed comprehensive integrative analyses of single-cell transcriptome and immune profiling of the blood of 8 Parkinson's patients and 13 healthy controls as well as the cerebrospinal fluid of 6 Parkinson's patients, 4 Alzheimer's patients, 5 mild cognitive impairment (MCI) patients and 9 healthy controls. In total, 22 T cell subsets with distinct functions and clonalities were identified from 121,402 T cells. We observed significant clonal expansion of effector CD8+ T cells in Parkinson's patients, which formed a gradient of transcriptional states from central memory CD8+ T cells to early effector CD8+ T cells followed by terminal effector CD8+ T cells. Shared TCRs in this progression suggest TCRs may be involved in the state transition of CD8+ T cells stimulated by antigens. Notably, we also found that a group of clonally expanded cytotoxic CD4+ T cells were significantly increased in Parkinson's patients compared to controls, suggesting their cytotoxic roles in Parkinson's disease. Finally, we screened putative TCR-antigen pairs that existed in both blood and cerebrospinal fluid of patients with Parkinson's disease. These results reveal an adaptive immune response in the blood and cerebrospinal fluid of Parkinson's disease and provide novel evidence of clonal, antigen-experienced T cells patrolling in the blood and cerebrospinal fluid of Parkinson's disease.</p>
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.