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52 results for “central metabolism”
Summer water chemistry, high frequency sensors, zooplankton and benthic macroinvertebrate community composition, periphyton, fish, and macrophyte biomass, along with lake metabolism and greenhouse gas dynamics in six experimental ponds in central Iowa, USA (2020)
This data product contains physical, chemical, and biological data ranging from the minute to daily to weekly scale in six artificial ponds (400 square meter surface area, 2m depth) in central Iowa (USA) 2020. Ponds were paired into three sets of treatment and reference with treatment ponds receiving two nutrient pulses designed to increase ambient phosphorus concentrations ~ 3 - 5%. Nitrogen and phosphorus were added as NH4NO3 and H3PO4, respectively, at a 24:1 molar ratio. The first nutrient pulse occurred on Julian day of year (DOY) 176 corresponding to a 3% increase and the second nutrient pulse occurred on DOY 211 to a 5% increase. Each treatment-reference set had a different food web structure established ranging between low, intermediate, and high complexity based on trophic connectivity and food chain length. Added to this data package is a document titled "2020 Iowa State University Horticultural Farm Experimental Ponds Nutrient Addition Experiment". For experimental set up, context, and a summary table of the data tables archived herein with available variables please review this document. It is added to aid in successful interpretation and to increase ease-of-use. Please email Tyler Butts (tyler.james.butts@gmail.com) for any and all questions regarding context or use of this dataset!
Physical, chemical, and metabolic leaf characteristics within sugar maple in the MELNHE study at Bartlett Experimental Forest, central NH USA, 2017
The MELNHE study looks at patterns of resource limitation through nutrient manipulations in three study sites in New Hampshire: Bartlett Experimental Forest, Hubbard Brook Experimental Forest, and Jeffers Brook, located in the White Mountain National Forest. The investigation is monitoring stem diameter, leaf area, sap flow, foliar chemistry, leaf litter production and chemistry, foliar nutrient resorption, root biomass and production, mycorrhizal associations, soil respiration, heterotrophic respiration, N and P availability, N mineralization, soil phosphatase activity, soil carbon and nitrogen, nutrient uptake capacity of roots, and mineral weathering. Applications of N and P began in June 2011 and continue at the rate of 30 kg N/ha/yr (as NH4NO3) and 10 kg P/ha/yr (as NaH2PO4). This data set includes physical, chemical, and metabolic leaf characteristics collected in a vertical transect within individual tree crowns. Because trees varied in crown depth, not all trees have the same number of samples collected. Depth from the top of the crown was measured and climbing ropes and a pole pruner were used to collect a population of leaves. These data were gathered as part of the Hubbard Brook Ecosystem Study (HBES). The HBES is a collaborative effort at the Hubbard Brook Experimental Forest, which is operated and maintained by the USDA Forest Service, Northern Research Station.
Phosphoglycerate kinase is a central leverage point in Parkinson's Disease driven neuronal metabolic deficits
<p><span>Although certain drivers of familial Parkinson’s Disease (PD) compromise mitochondrial integrity, whether metabolic deficits underly other idiopathic or genetic origins of PD is unclear. Here, we demonstrate that PGK1, a gene in the PARK12 susceptibility locus, <span> </span>is rate limiting in neuronal glycolysis and that modestly increasing PGK1 expression significantly boosts <span> </span>neuronal ATP production kinetics that is sufficient to suppress PARK20-driven synaptic dysfunction. We found that his activity enhancement depends on the molecular chaperone PARK7/DJ-1, whose loss of function significantly disrupts axonal bioenergetics. <em>In-vivo, </em>viral expression of PGK1 confers protection of striatal DA axons against metabolic lesions. These data support the notion that bioenergetic deficits may underpin PD associated pathologies and point to improving neuronal ATP production kinetics as a promising path forward in PD therapeutics.</span></p>
Data for the "Systematic mapping of protein-metabolite interactions in central metabolism of Escherichia coli"
<p>This dataset contains raw and processed NMR data used in the publication.</p>
Central obesity, body mass index, metabolic syndrome and mortality in Mediterranean breast cancer patients
<p>Importance: Obesity and metabolic disorders have been associated with an increased risk of cancer and with poorer outcomes in many cohorts of breast cancer (BC) patients, with poor evidence from Mediterranean cohorts. <br> Objective: To investigate the prognostic potential of anthropometric variables, namely body mass index (BMI), waist circumference (WC), waist-to-hip ratio (WHR), as well as Metabolic Syndrome (MetS) and its components, in early BC patients living in a Southern Mediterranean region of Italy.<br> Design: Prospective cohort study enrolling consecutive early BC patients who were treated between January 2009 and December 2013 in Southern Italy. Median follow-up was 11.8 years and ended on June 15th 2022. Physicians who measured the study variables were blinded to patient groupings.<br> Setting: Multicenter study enrolling consecutive, early BC patients referred to specialized cancer centers.<br> Participants: A total of 955 early BC patients consecutively treated at the Istituto Nazionale dei Tumori, “G. Pascale” and at the Policlinico University Hospital “Federico II”, Naples, Italy, were enrolled. All study subjects provided written informed consent to participate. <br> Intervention(s) (for clinical trials) and exposure (for observational studies): Anthropometric measurements and indices (BMI, hip circumference and WC) were collected. MetS was defined according to NCEP-ATP III criteria. MetS components were categorized as 0, 1-2 or ≥3. <br> Main Outcomes and Measures: Overall survival and BC-specific survival. <br> Results: Mean age was 55.3 years (±12.5 years); 61% of patients were post-menopausal. At the end of follow-up, 208 (22%) patients had died, 131 (14%) of whom from BC. Obesity (BMI≥30 kg/m2) was found in 29% of enrolled patients (14% in pre- and 38% in post-menopause); 24% of patients met the criteria for a diagnosis of MetS (7% in pre- and 36% in post-menopause), whereas 1-2 MetS criteria were found in 53% of patients<br> High WC or WHR were associated with a moderately increased risk of all-cause mortality (WC ≥ 88 cm, HR=1.39, 95%CI: 1.00-1.94; WHR > 0.85, HR=1.62, 95%CI: 1.12-2.37). Furthermore, an increased risk of all-cause mortality was observed with the presence of MetS (HR=1.61, 95%CI: 1.12-2.32). An increased BC-specific mortality risk was found in obese patients (BMI≥30 kg/m2, HR=1.72, 95%CI: 1.06-2.78) and in those with WC ≥88 (HR=1.71, 95%CI: 1.12-2.61). High WHR was also associated with increased risk of BC-specific mortality, both when evaluated as a categorical variable (WHR>0.85, HR=1.80, 95%CI: 1.13-2.86) and as a continuous variable (for each 0.1-U increase in WHR, HR=1.33, 95%CI: 1.08-1.63). The presence of MetS was associated with an 81% increased risk of BC-specific mortality (HR=1.81, 95%CI: 1.51-2.85). <br> These associations varied according to menopausal status. In particular, in pre-menopausal patients higher BMI was associated with an increased risk of both all-cause and BC-specific mortality (HR=1.43 and HR=1.58, respectively). In post-menopausal women an increased risk of all-cause mortality was found only in the presence of ≥3 MetS components (HR=2.77, 95%CI: 1.09-7.06). The associations among anthropometric variables and all-cause and BC-specific mortality also varied according to BC subtype. Triple negative BC was the only disease subtype that wasn’t independently associated with BMI, WC, WHR or MetS or all-cause and BC-specific mortality.<br> Conclusions and Relevance: Central obesity and metabolic disorders result in a highly increased risk of BC death. The magnitude of this effect suggests that obesity may nullify the benefit of effective BC therapies. Active lifestyle interventions to maintain optimal body weight and to prevent MetS should be recommended for several expected beneficial effects, including a potential reduction in BC-specific mortality.</p>
Central Mechanisms That Regulate Glucose Metabolism in Humans
ClinicalTrials.gov study NCT01028846. IPD Sharing: NO. Countries: 1. Publications: 1.
Influence of Prior Walking on Postprandial Metabolism in Centrally Obese Men
ClinicalTrials.gov study NCT03952000. IPD Sharing: YES. Countries: 1. Publications: 2.
Data from: Genetic perturbation of key central metabolic genes extends life span in Drosophila and affects response to dietary restriction
There is a connection between nutrient inputs, energy-sensing pathways, lifespan variation and aging. Despite the role of metabolic enzymes in energy homeostasis and their metabolites as nutrient signals, little is known about how their gene expression impacts lifespan. In this report, we use P-element mutagenesis in Drosophila to study the effect on lifespan of reductions in expression of seven central metabolic enzymes, and contrast the effects on normal diet and dietary restriction. The major observation is that for five of seven genes, the reduction of gene expression extends lifespan on one or both diets. Two genes are involved in redox balance, and we observe that lower activity genotypes significantly extend lifespan. The hexokinases also show extension of lifespan with reduced gene activity. Since both affect the ATP/ADP ratio, this connects with the role of AMP-activated protein kinase as an energy sensor in regulating lifespan and mediating caloric restriction. These genes possess significant expression variation in natural populations, and our experimental genotypes span this level of natural activity variation. Our studies link the readout of energy state with the perturbation of the genes of central metabolism and demonstrate their effect on lifespan.
Pathogenic Bacteria Remodel Central Metabolic Enzyme to Build a Cyclopropanol Warhead
<p>MS raw data used for generating Figure 2a/Supplementary Figure 1.</p> <p>NMR raw data of natural gonydiol.</p>
A metabolic map of E. coli's central metabolism
<p>A diagram showing the reactions, metabolites, co-factors, and enzymes in E. coli's central metabolism. A few select carbon sources and their catabolic pathways are shown as well.</p>
Proximity labeling-based profiling reveals a central role of the nuclear pore in mRNA metabolism
<p>The dataset for '<strong>Proximity labeling-based profiling reveals a central role of the nuclear pore in mRNA metabolism'</strong></p><p>This repository contains 81 high-confidence heterodimer complexes discussed in the publication. </p>
Blood Pressure and Central Vascular Stiffness in Obese Children. Relationship to Metabolic Disturbances and Subclinical Cardiovascular Damage. Effect of Weight Reduction
ClinicalTrials.gov study NCT01310088. IPD Sharing: Not stated. Countries: 1. Publications: 10.
Endotoxin & Cytokines. Do Protein Loss and Metabolic Effects Depend on Central Nervous System (CNS) Activation of Stress Hormones or on Local Mechanisms in Muscle and Fat?
ClinicalTrials.gov study NCT01452958. IPD Sharing: Not stated. Countries: 1. Publications: 1.
The Effect of Central Insulin on Insulin Sensitivity and Energy Metabolism
ClinicalTrials.gov study NCT01479075. IPD Sharing: Not stated. Countries: 1. Publications: 3.
Brain Energy Metabolism in Patients With Chronic Liver Disease and Impaired Central Nervous System
ClinicalTrials.gov study NCT00424957. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Impact of the Central Blood Pressure Level in Cerebral Metabolic Aging: a 18F-FDG PET Study.
ClinicalTrials.gov study NCT03345290. IPD Sharing: UNDECIDED. Countries: 1. Publications: 1.
Data from: Modeling central metabolism and energy biosynthesis across microbial life
Open the record for dataset details and reuse information.
Data from: Genetic perturbation of key central metabolic genes extends life span in Drosophila and affects response to dietary restriction
Open the record for dataset details and reuse information.
The TCA (TriCarboxylic Acid) Cycle/Citric Acid Cycle/Krebs cycle acts as a central metabolic hub
<p>Diagram depicting the TCA (TriCarboxylic Acid) Cycle/Citric Acid Cycle/Krebs cycle and its relation to a variety of macromolecules</p>
Metabolic and Immunomic Differential Analysis of Primary Central Nervous System Diffuse Large B-Cell Lymphoma
ClinicalTrials.gov study NCT07188077. IPD Sharing: UNDECIDED. Countries: 1. Publications: 0.
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.