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615 results for “central nervous system”
Dataset for manuscript "During haptic communication, the central nervous system compensates distinctly for delay and noise"
<p>Data relating to the manuscript "Dataset for manuscript "During haptic communication, the central nervous system compensates distinctly for delay and noise". This includes the experiment dataset (in file experiment_dataset.csv) as well as the MATLAB functions used for the development of the simulation model (with main function main_delay.m)</p>
The genomic and transcriptional landscape of primary central nervous system lymphoma
<p>Primary lymphomas of the central nervous system (PCNSL) are mainly diffuse large B-cell lymphomas (DLBCLs) confined to the central nervous system (CNS). Despite extensive research, the molecular alterations leading to PCNSL have not been fully elucidated. In order to provide a comprehensive description of the genomic and transcriptional landscape of PCNSL, we here performed whole-genome and transcriptome sequencing and integrative analysis of 51 lymphomas presenting in the CNS, including 42 EBV-negative PCNSL, 6 secondary CNS lymphomas (SCNSL) and 3 EBV+ CNSL and matched controls. The results were compared to an independent validation cohort of 31 FFPE CNSL specimens (PCNSL, n = 19; SCNSL, n = 9; EBV+ CNSL, n = 3) and 36 systemic DLBCL cases outside the CNS.</p> <p>This repository contains tab separated value text files:</p> <p>- Radke_et_al_supplementary_somatic_CNVs.tsv (somatic copy number variations predicted by ACEseq)<br> - Radke_et_al_supplementary_somatic_indels.tsv (somatic indels predicted by the DKFZ platypus workflow)<br> - Radke_et_al_supplementary_somatic_indels_exonic.tsv (somatic exonic indels predicted by the DKFZ platypus workflow)<br> - Radke_et_al_supplementary_somatic_mutations_integrated.tsv (table of gene by patients, stating which mutations were observed) <br> - Radke_et_al_supplementary_somatic_mutations_integr_integrated_including_kataegis_counts.tsv (table of gene by patients, stating which mutations were observed, including the count of mutations falling into kataegis hotspots) <br> - Radke_et_al_supplementary_somatic_SNVs.tsv (somatic SNVs predicted by the DKFZ mpileup workflow)<br> - Radke_et_al_supplementary_somatic_SNVs_exonic_functional.tsv (somatic exonic SNVs predicted by the DKFZ mpileup workflow)<br> - Radke_et_al_supplementary_somatic_SNVs_rescued_by_TiNDA (mutations initially classified as germline, but likely tumor mutations based on VAF modelling by TiNDA)<br> - Radke_et_al_supplementary_somatic_SVs.tsv (somatic structural variations predicted by the DKFZ Sophia workflow)<br> - Radke_et_al_supplementary_RNAseq_numReads_CNSLs.tsv (RNAseq read counts calculated by the DKFZ RNAseq workflow)</p> <p>This repository contains the raw unedited images from the manuscript:</p> <p>- Radke_et_al_Main_Figure_1c_BCL6.tif (raw unedited image for Main Figure 1c - BCL6)<br> - Radke_et_al_Main_Figure_1c_CD10.tif (raw unedited image for Main Figure 1c - CD10)<br> - Radke_et_al_Main_Figure_1c_MUM1.tif (raw unedited image for Main Figure 1c - MUM1)<br> - Radke_et_al_Supplementary_Figure_1a_CD20.tif (raw unedited image for Supplementary Figure 1a - CD20)<br> - Radke_et_al_Supplementary_Figure_1a_EBV.tif (raw unedited image for Supplementary Figure 1a - EBV)<br> - Radke_et_al_Supplementary_Figure_1a_HE_(FFPE).tif (raw unedited image for Supplementary Figure 1a - HE (FFPE))<br> - Radke_et_al_Supplementary_Figure_1a_HE_(frozen)_1.tif (raw unedited image for Supplementary Figure 1a - HE (frozen) 1)<br> - Radke_et_al_Supplementary_Figure_1a_HE_(frozen)_2.tif (raw unedited image for Supplementary Figure 1a - HE (frozen) 2)<br> - Radke_et_al_Supplementary_Figure_1a_HE_(frozen)_3.tif (raw unedited image for Supplementary Figure 1a - HE (frozen) 3)<br> - Radke_et_al_Supplementary_Figure_1a_Ki67.tif (raw unedited image for Supplementary Figure 1a - Ki67)<br> - Radke_et_al_Supplementary_Figure_1b_EBV_PCR.pptx (raw unedited image for Supplementary Figure 1b - EBV PCR )<br> - Radke_et_al_Supplementary_Figure_1c_CDKN2A_FISH_1.jpg (raw unedited image for Supplementary Figure 1c - CDKN2A FISH 1)<br> - Radke_et_al_Supplementary_Figure_1c_CDKN2A_FISH_2.jpg (raw unedited image for Supplementary Figure 1c - CDKN2A FISH 2)<br> - Radke_et_al_Supplementary_Figure_7h_PD-L1_LS-033.tif (raw unedited image for Supplementary Figure 7h - PD-L1 LS-033)<br> - Radke_et_al_Supplementary_Figure_7h_PD-L1_LS-031.tif (raw unedited image for Supplemnetary Figure 7h - PD-L1 LS-031)</p>
Expression of immunoglobulin constant domain genes in neurons of the mouse central nervous system
<p>Data related to the publication "Expression of immunoglobulin constant domain genes in neurons of the mouse central nervous system". </p> <p>The fasta file (.fa) contains the sequence of neuronal FC-Ighm</p> <p>The .pdb files contain the model of the two different protein versions of Ighm</p> <p>The excel file contains the data of the quantification of co-expression and the ATG prediction results.</p>
The central nervous system's proteogenomic and spatial imprint upon systemic viral infection, like SARS-CoV-2
<p>Data set including image files of histological stainings, immunohistochemistry, MELC, and spatial transcriptomics associated with the study mentioned above.</p>
Processed Vectra images for primary central nervous system lymphoma (PCNSL) patients
<ul> <li>FFPE materials</li> </ul> <p>Formalin-fixed paraffin-embedded (FFPE) tumor samples and clinical data were obtained from PCNSL patients enrolled in the HOVON105/ALLG NHL 24 intergroup, multicenter, open-label, randomized phase 3 study (NTR2437 and ACTRN12610000908033) through the HOVON Pathology Facility and Biobank. </p> <ul> <li>Muiltiplex imaging</li> </ul> <p>Multiplex immunofluorescence was performed on 4-µm-thick formalin-fixed, paraffin-embedded whole tissue sections using the Opal 7-color fluorescence immunohistochemistry (IHC) kit (Akoya biosciences, USA), as previously described. In brief, slides were deparaffinized and rehydrated, followed by a blocking step for endogenous peroxidase using 0.3% H<sub>2</sub>O<sub>2</sub>/methanol and fixation with 10% neutral buffered formalin (Leica Biosystems, Germany). Slides were washed in Milli-Q water and 0.05% Tween20 in 1x Tris-Buffered Saline (TBS-T). Antigen retrieval was done by placing the slides in 0.05% ProClin300/Tris–EDTA buffer pH 9.0 in a microwave at 100% power until boiling, followed by 15 min at 30% power. Slides were cooled in Milli-Q water, washed in 1x TBS-T and blocked with Antibody Diluent (Agilent, USA). The slides were then incubated with primary antibody diluted in Normal Antibody Diluent, followed by incubation with the broad spectrum HRP from the SuperPicture Polymer Detection Kit (Life Technologies, USA). Next, the slides were incubated with Opal TSA fluorochromes diluted in an amplification buffer (Akoya biosciences, USA). The primary and secondary antibody complex was stripped by microwave treatment with 0.05% ProClin300/Tris–EDTA buffer at pH 9.0. Finally, DAPI working solution (Akoya biosciences, USA) was applied and the slides were mounted with Prolong Diamond Anti-fade mounting medium (#P36965; Life Technologies).</p> <ul> <li>Image processing</li> </ul> <p>Stained slides were scanned using the Vectra Polaris Automated Quantitative Pathology Imaging System (Akoya biosciences, USA). From each slide, representative tumor regions and regions at the junction of tumor and surrounding cerebral tissue were selected and multispectral imaging (MSI) images were acquired at 40x resolution. After image capture, the images were spectrally unmixed and analyzed, using supervised machine learning algorithms within Inform 4.2.2. (Akoya biosciences). Cells were assigned into ten different phenotype categories: “PAX5+PD-L1-”, “PAX5+PD-L1+”, “CD163+PD-L1-”, “CD163+PD-L1+”, “CD3+CD8-PD-1-”, “CD3+CD8+PD-1-”, “CD3+CD8-PD-1+”, “CD3+CD8+PD-1+”, “other PD-L1+” or “other”, based on the size of the cells and positivity of markers in the panel. </p> <p> </p>
A Safety and Dose Ranging Study of Idursulfase (Intrathecal) Administration Via an Intrathecal Drug Delivery Device in Pediatric Patients With Hunter Syndrome Who Have Central Nervous System Involveme
ClinicalTrials.gov study NCT00920647. IPD Sharing: YES. Countries: 2. Publications: 1.
Lipoic acid protects the central nervous system by immunomodulation and antioxidation
<p>Lipoic acid protects the central nervous system by immunomodulation and antioxidation. In the periphery, LA prevents inflammatory cells from crossing the BBB and protects brain endothelial cells. In the CNS, LA inhibits the activity of T cells/microglia, decreases the expression of TNF-α and IFN-γ, and neutralizes ROS and NO.</p>
Paleoneurology of stem palaeognaths clarifies the plesiomorphic condition of the crown bird central nervous system
<p>This dataset contains additional brain and endosseous labyrinth endocasts generated by Widrig et al. (2024) Paleoneurology of stem palaeognaths clarifies the plesiomorphic condition of the crown bird central nervous system.</p>
Small brains: Body shape constrains tissue allocation to the central nervous system in ant-mimicking spiders
<p>In Batesian mimicry, mimetic traits are not always as convincing as predicted by theory – in fact, inaccurate mimicry with only a superficial model resemblance is common and taxonomically widespread. The ‘selection trade-offs hypothesis’ proposes a life-history trade-off between accurate mimetic traits and one or more vital biological functions. Here, using an accurate myrmecomorphic (ant-mimicking) jumping spider species, <em>Myrmarachne smaragdina</em>, we investigate how myrmecomorphic modifications to the body shape impact the internal anatomy in a way that could be functionally limiting. Specifically, via X-ray micro-computed tomography (microCT), we quantify how the spider’s constricted prosoma, which emulates the head and thorax of ants, impacts the size of the central nervous system (CNS) and the venom glands. We found that, relative to their whole-body mass, the CNS of the ant-mimicking jumping spider was smaller when compared with a relatively closely related non-mimic jumping spider, indicating that some trade-off between mimic accuracy and size of neural anatomy, as articulated by the ‘selection trade-offs hypothesis’, is a possibility. Our explorative evidence enables and encourages broader investigation of how variable mimic accuracy impacts the neuroanatomy in ant mimics as a direct test of the ‘selection trade-offs hypothesis’. </p>
Rituximab and Combination Chemotherapy in Treating Patients With Primary Central Nervous System Lymphoma
ClinicalTrials.gov study NCT00335140. IPD Sharing: YES. Countries: 1. Publications: 1.
A Study to Evaluate Central Nervous System (CNS) Pharmacodynamic Activity of TAK-653 in Healthy Participants Using Transcranial Magnetic Stimulation (TMS)
ClinicalTrials.gov study NCT03792672. IPD Sharing: YES. Countries: 1. Publications: 1.
Buparlisib (BKM120) In Patients With Recurrent/Refractory Primary Central Nervous System Lymphoma (PCNSL) and Recurrent/Refractory Secondary Central Nervous System Lymphoma (SCNSL)
ClinicalTrials.gov study NCT02301364. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Combination Chemotherapy, Radiation Therapy, and an Autologous Peripheral Blood Stem Cell Transplant in Treating Young Patients With Atypical Teratoid/Rhabdoid Tumor of the Central Nervous System
ClinicalTrials.gov study NCT00653068. IPD Sharing: Not stated. Countries: 3. Publications: 2.
Acyclovir for Herpes Infections Involving the Central Nervous System in Neonates
ClinicalTrials.gov study NCT00031460. IPD Sharing: Not stated. Countries: 2. Publications: 1.
Radiation Therapy in Preventing Central Nervous System (CNS) Metastases in Patients With Non-Small Cell Lung Cancer
ClinicalTrials.gov study NCT00048997. IPD Sharing: Not stated. Countries: 1. Publications: 4.
A Study to Evaluate the Safety and Efficacy of Nivolumab Monotherapy and Nivolumab in Combination With Ipilimumab in Pediatric Participants With High Grade Primary Central Nervous System (CNS) Maligna
ClinicalTrials.gov study NCT03130959. IPD Sharing: NO. Countries: 15. Publications: 1.
Sunitinib in Sarcomas of the Central Nervous System
ClinicalTrials.gov study NCT03641326. IPD Sharing: NO. Countries: 1. Publications: 3.
Efficacy and Safety of Gadopiclenol for Central Nervous System (CNS) Magnetic Resonance Imaging (MRI)
ClinicalTrials.gov study NCT03996447. IPD Sharing: Not stated. Countries: 11. Publications: 1.
Safety and Feasibility Study of Combination of State of Art Chemoimmunotherapy, Intensive Central Nervous System Prophylaxis and Scrotal Irradiation to Treat Primary Diffuse Large B-cell Lymphoma of T
ClinicalTrials.gov study NCT00945724. IPD Sharing: Not stated. Countries: 2. Publications: 1.
The Maraviroc Central Nervous System (CNS) Study
ClinicalTrials.gov study NCT00982878. IPD Sharing: NO. Countries: 1. Publications: 1.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.