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307 results for “cerebrovascular”
Data from: Adiposity is related to cerebrovascular and brain volumetry outcomes in the RUN DMC Study
Objective: Adiposity predictors, body mass index (BMI), waist circumference (WC), and blood leptin and total adiponectin levels were associated with components of cerebral small vessel disease (CSVD) and brain volumetry in 503 adults with CSVD age ≥50 years and enrolled in the Radboud University Nijmegen Diffusion tensor and Magnetic resonance imaging Cohort (RUN DMC). Methods: RUN DMC participants were followed for 9 years (2006-2015). BMI, WC, brain imaging and dementia diagnoses were evaluated at baseline and follow-up. Adipokines were measured at baseline. Brain imaging outcomes included CSVD components, white matter hyperintensities, lacunes and microbleeds; and gray and white matter, hippocampal, total brain, and intracranial volumes. Results: Cross-sectionally among men at baseline, higher BMI, WC and leptin were associated with lower gray matter and total brain volumes, and higher BMI and WC were associated with lower hippocampal volume. At follow-up 9 years later, higher BMI was cross-sectionally associated with lower gray matter volume, and an obese WC (>102cm) was protective for >1 lacune or >1 microbleed in men. In women, increasing BMI and overweight or obesity (BMI >25 kg/m2 or WC >88 cm) were associated with >1 lacune. Longitudinally, over 9 years, a baseline obese WC was associated with decreasing hippocampal volume particularly in men, and increasing WMH volume in women and men. Conclusions: Anthropometric and metabolic adiposity predictors were differentially associated with CSVD component and brain volumetry outcomes by sex. Higher adiposity is associated with a vascular-neurodegenerative spectrum among adults at-risk for vascular forms of cognitive impairment and dementias.
Rhythm control and cardiovascular or cerebrovascular out-comes in patients with atrial fibrillation: A study of the CODE-AF registry
<p><strong>SUPPLEMENTARY MATERIAL</strong></p> <p> </p> <p><strong><em>Rhythm control and cardiovascular or cerebrovascular outcomes in patients with atrial fibrillation: A study of the CODE-AF registry</em></strong></p> <p> </p> <p>Ho Gi Chung, MD; Junbeom Park; Jin-Kyu Park; Ki-Woon Kang; Jaemin Shim; Jin-Bae Kim; Jun Kim; Eue-Keun Choi; Hyung Wook Park; Young Soo Lee; Boyoung Joung</p> <table> <tbody> <tr> <td> <p><strong>Supplementary Table 1.</strong> Subgroup analysis of primary outcome in rate- and rhythm-control group before overlap weighting.</p> </td> </tr> </tbody> </table> <table> <tbody> <tr> <td> <p><strong>Supplementary Figure 1. </strong>Cumulative incidence of primary outcome in rhythm and rate control treatment groups before overlap weighting.</p> </td> </tr> </tbody> </table> <table> <tbody> <tr> <td> <p><strong>Supplementary Figure 2. </strong>Cumulative incidence of secondary outcomes in rhythm and rate control treatment groups before overlap weighting.</p> </td> </tr> </tbody> </table>
Vascular Ultrasound Screening in Patients With Ischemic Cerebrovascular Disease: a Multi-center Registry Study
ClinicalTrials.gov study NCT02397655. IPD Sharing: NO. Countries: 1. Publications: 3.
Diagnosis and Treatment of Sleep Apnea in Cerebrovascular Disease
ClinicalTrials.gov study NCT00984308. IPD Sharing: UNDECIDED. Countries: 1. Publications: 7.
PACESETTER: Program to Avoid Cerebrovascular Events Through Systematic Electronic Tracking and Tailoring of an Eminent Risk-factor
ClinicalTrials.gov study NCT03401489. IPD Sharing: NO. Countries: 1. Publications: 1.
Assessing Neurocognition After Cerebrovascular Intervention
ClinicalTrials.gov study NCT03344276. IPD Sharing: NO. Countries: 1. Publications: 8.
Data from: Adiposity is related to cerebrovascular and brain volumetry outcomes in the RUN DMC Study
Open the record for dataset details and reuse information.
Cerebrovascular alterations in a mouse model of late-onset Alzheimer's disease
Open the record for dataset details and reuse information.
Example Data for 3D quantification of zebrafish cerebrovascular architecture
<p>Example data for:</p> <p>E. C. Kugler, J. Frost, V. Silva, K. Plant, K. Chhabria, T. J.A. Chico, P. A. Armitage</p> <p>3D quantification of zebrafish cerebrovascular architecture by automated image analysis of light sheet fluorescence microscopy datasets</p> <p>bioRxiv 2020.08.06.239905; doi: https://doi.org/10.1101/2020.08.06.239905</p> <p>Link: https://www.biorxiv.org/content/10.1101/2020.08.06.239905v2</p> <p><br> Code: https://github.com/ElisabethKugler/ZFVascularQuantification (doi:https://doi.org/10.5281/zenodo.3978278)</p> <p>Transgenic zebrafish 3dpf: Tg(kdrl:HRAS-mCherry)s916<br> Acquisition: Zeiss Z.1 light sheet microscope with a Plan-Apochromat 20x/1.0 Corr nd=1.38 objective, sCMOS detection unit. <br> Activated pivot scan, dual-sided illumination and online fusion; <br> properties of acquired data are as follows: 0.7x zoom, 16bit image depth, 1920 x 1920px (approximately 0.33 x 0.33 µm) image size and minimum z-stack interval (approximately 0.5µm), <br> 561nm laser, LP560, and LP585.</p> <p>Data: <br> - tiff and MIPs<br> - TF: pre-processed with Sato enhancement<br> - TH: segmented with Otsu thresholding<br> - 512x512: downsampled<br> - Reg: intersample registration<br> - analysis: folder for quantification</p>
Data from: An MRI measure of degenerative and cerebrovascular pathology in Alzheimer's disease
Objective: To develop, replicate, and validate an MRI-based quantitative measure of both cerebrovascular and neurodegeneration in Alzheimer's disease for clinical and potentially research purposes. Methods. We used data from a cross-sectional and longitudinal community-based study of Medicare-eligible residents in northern Manhattan followed every 18-24 months (N=1,175, mean age=78 years). White matter hyperintensities, infarcts, hippocampal volumes, and cortical thicknesses were quantified from MRI and combined to generate an MRI measure associated with episodic memory. The combined MRI measure was replicated and validated using autopsy data, clinical diagnoses, and cerebrospinal fluid biomarkers and amyloid PET from the Alzheimer's Disease Neuroimaging Initiative. Results. The quantitative MRI measure was developed in a group of community participants (n=690) and replicated in a similar second group (n=485). Compared with healthy controls, the quantitative MRI measure was lower in patients with mild cognitive impairment and lower still in those with clinically diagnosed Alzheimer's disease. The quantitative MRI measure correlated with neurofibrillary tangles, neuronal loss, atrophy, and infarcts at postmortem in an autopsy subset and was also associated with PET amyloid imaging and cerebrospinal fluid levels of total tau, p-tau, and Aβ42. The MRI measure predicted conversion to MCI and clinical Alzheimer's disease among healthy controls. Conclusions. We developed, replicated and validated an MRI measure of cerebrovascular and neurodegenerative pathologies that are associated with clinical and neuropathological diagnosis of Alzheimer's disease and related to established biomarkers.
Data from: Early detection of cerebrovascular pathology and protective antiviral immunity by MRI
<p>Central nervous system (CNS) infections are a major cause of human morbidity and mortality worldwide. Even patients that survive CNS infections can have lasting neurological dysfunction resulting from immune and pathogen induced pathology. Developing approaches to noninvasively track pathology and immunity in the infected CNS is crucial for patient management and development of new therapeutics. Here, we develop novel MRI-based approaches to monitor virus-specific CD8+ T cells and their relationship to cerebrovascular pathology in the living brain. We studied a relevant murine model in which a neurotropic virus (vesicular stomatitis virus) was introduced intranasally and then entered the brain via olfactory sensory neurons – a route exploited by many pathogens in humans. Using T2*-weighted high-resolution MRI, we identified small cerebral microbleeds as the earliest form of pathology associated with viral entry into the brain. Mechanistically, these microbleeds occurred in the absence of peripheral immune cells and were associated with infection of vascular endothelial cells. We monitored the adaptive response to this infection by developing methods to iron label and track individual virus specific CD8+ T cells by MRI. Transferred antiviral T cells were detected in the brain within a day of infection and were able to reduce cerebral microbleeds. These data demonstrate the utility of MRI in detecting the earliest pathological events in the virally infected CNS as well as the therapeutic potential of antiviral T cells in mitigating this pathology.</p>
Cerebrovascular disease progression in patients with ACTA2 Arg179 pathogenic variants supplementary materials
<p><span><span><span><span><span><span><span><span><span><span><span>Our study entitled "Cerebrovascular disease progression in patients with ACTA2 Arg179 Pathogenic Variants" examines progression of imaging biomarkers of stroke, arterial steno-occlusive disease and white matter injury in patients with smooth muscle dysfunction syndrome caused by mutations in the ACTA2 gene (ACTA2 Arg179 pathogenic variants). We found characteristic patterns of acute white matter ischemic injury and progressive internal carotid artery stenosis on MRI. Longitudinal analysis showed both stable and progressive lesion entities. The data was collected on various scanner setups. To eliminate potential bias related to improving imaging technology we re-analyzed imaging markers for those patients with available longitudinal imaging on an identical scanner setups and present the data in supplementary table e-1. Supplementary table e-2 shows results of a comparison of imaging markers between male and female sex.</span></span></span></span></span></span></span></span></span></span></span></p>
Measure of Cerebrovascular Dysfunction After TBI With fNIRS
ClinicalTrials.gov study NCT01789164. IPD Sharing: NO. Countries: 1. Publications: 3.
Effects of Spironolactone on Cardio- and Cerebrovascular Morbidity and Mortality in Hemodialysis Patients
ClinicalTrials.gov study NCT01687699. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Sildenafil for Cerebrovascular Dysfunction in Chronic Traumatic Brain Injury.
ClinicalTrials.gov study NCT01762475. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Correlation Between Reticulated Platelets and Major Adverse Cardiac and Cerebrovascular Events After Noncardiac Surgery
ClinicalTrials.gov study NCT02097602. IPD Sharing: Not stated. Countries: 1. Publications: 6.
Neuro Anatomical Correlation of Oropharyngeal Swallowing Revisited in Cerebrovascular Stroke Patients
ClinicalTrials.gov study NCT05603377. IPD Sharing: UNDECIDED. Countries: 1. Publications: 4.
Silent Cerebrovascular Lesion and Cognitive Decline Prevention by Cholesterol Lowering in Elderly AF Patients
ClinicalTrials.gov study NCT00449410. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Pathogenesis and Cerebrovascular Manifestations of Septic Encephalopathy
ClinicalTrials.gov study NCT00410111. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Detection and Neurological Impact of Cerebrovascular Events in Cardiac Surgery Patients
ClinicalTrials.gov study NCT04241289. IPD Sharing: NO. Countries: 1. Publications: 8.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.