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9 results for “chemoreceptor”
Convergent loss of chemoreceptors across independent origins of slave-making in ants
<p>Manual annotations and sequence files of olfactory and gustatory receptors in eight species of ants (slave-making ants, hosts and non-host species) spanning 3 independent origins of slave-making. These manual annotations were investigated for patterns of convergent gain or loss in slave-making ants compared to their hosts and vice versa. We highlighted extensive losses of chemoreceptors in slave-making ants compared to hosts, indicating a loss in perception accompanying the transition to social parasitism, with some degree of convergent molecular evolution at the level of individual genes.</p> <p>For the full study, see doi:10.1093/molbev/msab305</p>
Data from: Remote homolog detection places insect chemoreceptors in a cryptic protein superfamily spanning the tree of life
<p><span>Many proteins exist in the so-called "twilight zone" of sequence alignment, where low pairwise sequence identity makes it difficult to determine homology and phylogeny. As protein tertiary structure is often more conserved, recent advances in<em> ab initio </em>protein folding have made structure-based identification of putative homologs feasible. However, structural screening and phylogenetics are in their infancy, particularly for twilight zone proteins. We present a pipeline for the identification and characterization of distant homologs, and apply it to 7-transmembrane domain ion channels (7TMICs), a protein group founded by insect Odorant and Gustatory receptors. Previous sequence and limited structure-based searches identified putatively-related proteins, mainly in other animals and plants. However, very few 7TMICs have been identified in non-animal, non-plant taxa. Moreover, these proteins' remarkable sequence dissimilarity made it uncertain if disparate 7TMIC types (Gr/Or, Grl, GRL, DUF3537, PHTF and GrlHz) are homologous or convergent, leaving their evolutionary history unresolved. Our pipeline identified thousands of new 7TMICs in archaea, bacteria and unicellular eukaryotes. Using graph-based analyses and protein language models to extract family-wide signatures, we demonstrate that 7TMICs have structure and sequence similarity, supporting homology. Through sequence and structure-based phylogenetics, we classify eukaryotic 7TMICs into two families (Class-A and Class-B), which are the result of a gene duplication predating the split(s) leading to Amorphea (animals, fungi and allies) and Diaphoretickes (plants and allies). Our work reveals 7TMICs as a cryptic superfamily with origins close to the evolution of cellular life. More generally, this study serves as a methodological proof of principle for the identification of extremely distant protein homologs.</span></p>
Materials for rattlesnake chemoreceptor gene expression
Open the record for dataset details and reuse information.
Data from: Remote homolog detection places insect chemoreceptors in a cryptic protein superfamily spanning the tree of life
Open the record for dataset details and reuse information.
Study on Reflex Response During Temporary Stimulation and Inhibition of Chemoreceptors of Carotid Bodies - a Pilot Study
ClinicalTrials.gov study NCT01939912. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Collection of Gastrointestinal Tissue Samples for the Characterization and ex Vivo Functional Assessment of Chemoreceptors
ClinicalTrials.gov study NCT02859116. IPD Sharing: NO. Countries: 1. Publications: 18.
Effects of P2Y12 Receptor Inhibitors on Central and Peripheral Chemoreceptors' Sensitivity
ClinicalTrials.gov study NCT05080478. IPD Sharing: UNDECIDED. Countries: 1. Publications: 0.
Blue light perception by epiphytic Pseudomonas syringae drives chemoreceptor expression enabling efficient plant infection
GEO Series GSE152188. Pseudomonas syringae pv. tomato str. DC3000. 16 samples. Type: Expression profiling by array.
Chemoreceptor hyperactivity in heart failure: is lactate the culprit?
<p>we propose that in patients with HF, the blunted cardiac output during exercise results in inadequate oxygen delivery to working muscle, and earlier anaerobic metabolism which increase both lactate production and H+ and both are stimulus that augment the ventilatory drive and induce an early reduction of PaCO2 tensions.</p> <p>The link between lactate and hyperventilation is further supported by the demonstration that a reduction of arterial lactate concentration throughout exercise is associated with a reduction of ventilatory response to exercise in patients with HF after 2 months of exercise training.10 Also, reduction of blood lactate concentrations by dichloroacetate administration is associated with an improvement of myocardial function in patients with HF.</p> <p>We recognize that the documentation of the correlation between blood lactate concentration and VE/VCO2 slope during exercise in HF does not prove a cause-effect relationship. Accordingly, the present report should be considered only as hypothesis generating but this fascinating hypothesis has a strong physiological background but needs to be confirmed by dedicated studies.</p> <p></p>
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.