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216 results for “cholera”
Oral cholera vaccine coverage survey, Goma, August 2022
<p>Dataset collected during Vaccination Coverage Survey for Oral Cholera Vaccine in Goma, August 2022</p>
Interviews for New Business Models for Pharmaceutical Innovation and Access to Medicines - Case Study of the Oral Cholera Vaccine Development
<p>These supplementary materials represent the partial dataset in the form of semi-structured interviews, collected and analyzed in the research article "The 30-year evolution of oral cholera vaccines: A case study of a collaborative network alternative innovation model". This article is one of the outcomes of the "New Business Models for Pharmaceutical Innovation and Global Access to Medicines" research project, conducted at the Global Health Center, within the Geneva Graduate Institute. The dataset contains 8/16 interviews collected and used in this article, which are published with the informed consent of the interviewees.</p>
The functions of cholera toxin subunit B as a modulator of silica nanoparticle endocytosis
<p>The gastrointestinal tract is the main target of orally ingested nanoparticles (NPs) and at 9 the same time exposed to noxious substances, such as bacterial components. We investigated the 10 interaction of 59 nm silica (SiO2) NPs with differentiated Caco-2 intestinal epithelial cells in the pres-11 ence of cholera toxin subunit B (CTxB) and compared the effects to J774A.1 macrophages. CTxB can 12 affect cellular functions and modulate endocytosis via binding to the monosialoganglioside (GM1) 13 receptor, expressed on both cell lines. After stimulating macrophages with CTxB, we observed no-14 table changes in the membrane structure but not in Caco-2 cells and no secretion of the pro-inflam-15 matory cytokine TNF-α was detected. Cells were then exposed to 59 nm SiO2 NPs and CtxB sequen-16 tially and simultaneously, resulting in a high NPs uptake in J774A.1 cells but no uptake in Caco-2 17 cells was detected. Flow cytometry analysis revealed that exposure of J774A.1 cells to CTxB resulted 18 in a significant reduction in the uptake of SiO2 NPs. In contrast, the uptake of NPs by highly selective 19 Caco-2 cells remained unaffected following CTxB exposure. Based on colocalization studies, CTxB 20 and NPs might enter cells via shared endocytic pathways, followed by their sorting into different 21 intracellular compartments. Our findings provide new insights into the CTxB function to modulate 22 SiO2 NPs uptake in phagocytic but not in differentiated intestine cells.</p>
Vibrio cholerae codon biased genes list
<p>Files called top25: For each codon, 25% of genes with highest differential codon usage are listed. </p> <p>Files called top: For each codon, top genes with highest differential codon usage are listed, as indicated by violin plots in pdf files. </p> <p>Excel sheet with assigned codon usage for each codon and each gene.</p> <p>Whole genome of Vibrio cholerae N16961</p>
Fig. 4 in Bactericidal properties of mangrove Bruguiera cylindrica (L.) Blume leaf and Rhizophora mucronata Poir. stilt root extracts on Vibrio cholera, MTCC 435 and Escherichia coli pathogens
Fig. 4 — Percentage viability of HeLa cells with different mangrove extracts. Values are mean of triplicate reading (mean±SD)
Fig. 3 in Bactericidal properties of mangrove Bruguiera cylindrica (L.) Blume leaf and Rhizophora mucronata Poir. stilt root extracts on Vibrio cholera, MTCC 435 and Escherichia coli pathogens
Fig. 3 — SEM images of mangrove extracts with treated and un-treated bacterial cells: (a) Un-treated; (b) MTCC 435 treated with R. mucronata acetone stilt root extract; (c) MTCC 435 treated with B. cylindrica acetone leaf extract; (d) Un-treated Escherichia coli; (e) Escherichia coli treated with R. mucronata acetone stilt root extract; (f) Escherichia coli treated with B. cylindrica ethyl acetate leaf extract; (g) Un-treated Vibrio cholera; and (h) Vibrio cholerae treated with R. mucronata acetone stilt root extract
Fig. 2 in Bactericidal properties of mangrove Bruguiera cylindrica (L.) Blume leaf and Rhizophora mucronata Poir. stilt root extracts on Vibrio cholera, MTCC 435 and Escherichia coli pathogens
Fig. 2 — Viable count analysis of the bacterial pathogens - I: Collected solvent extract; II: Control plates [a) MTCC 435, g) E. coli, m) V. cholerae; b, h & n: Tetracycline (40 µg.ml-1) treated plates - (b) MTCC 435, h) E. coli, and n) V. cholerae); c, e, i, k & o: X- MBC concentration treated plates - (c) MTCC 435 with R. mucronata acetone stilt root extract, e) MTCC 435 with B. cylindrica acetone leaf extract, i) E. coli with R. mucronata acetone stilt root extract, k) E. coli with B. cylindrica acetone leaf extract, and o) V. cholerae with B. cylindrica ethyl acetate leaf extract); d, f, j, l & p: 2X-MBC concentration treated plates - (d) MTCC 435 with R. mucronata acetone stilt root extract, f) MTCC 435 with B. cylindrica acetone leaf extract, j) E. coli with R. mucronata acetone stilt root extract, l) E. coli with B. cylindrica acetone leaf extract, and p) V. cholerae with B. cylindrica ethyl acetate leaf extract)]
Fig. 1 in Bactericidal properties of mangrove Bruguiera cylindrica (L.) Blume leaf and Rhizophora mucronata Poir. stilt root extracts on Vibrio cholera, MTCC 435 and Escherichia coli pathogens
Fig. 1 — Effect of various extracts on growth pattern of clinical pathogens: a) R. mucronata acetone stilt root extract with MTCC 435; b) B. cylindrica acetone leaf extract with MTCC 435; c) R. mucronata acetone stilt root extract with E. coli; d) B. cylindrica acetone leaf extract with E. coli; and e) B. cylindrica ethyl acetate leaf extract with V. cholera
Data on the occurrence of Vibrio spp. of public health importance (i.e. Vibrio parahaemolyticus, Vibrio vulnificus, and Vibrio cholerae non-O1/non-O139) in seafood in European countries (Jan 2010-Sept 2023)
<p><span>This file contains data on the occurrence of <em><span>Vibrio</span></em><span> spp. of public health importance (<em>i.e</em>. <em>Vibrio parahaemolyticus</em>, <em>Vibrio vulnificus,</em> and <em>Vibrio cholerae </em>non-O1/non-O139) in seafood produced and/or commercialized in Europe, </span>covering studies published between January 2010 and September 2023. </span><span>The systematic review protocol used to identify and extract the information is available at <a href="../doi/10.5281/zenodo.10282513"><span>https://zenodo.org/doi/10.5281/zenodo.10282513</span></a> .</span></p>
Single cell annotations in 3D bacterial biofilms of Vibrio cholerae
<p>This repository contains the data to reproduce the study `Single-cell segmentation in bacterial biofilms with optimized convolutional neural networks enables tracking of cell lineages and measurements of growth rates` by Jelli, Ohmura, Netter, et al. It contains the following four subfolders:</p> <p> </p> <p>- `training-data-from-experimentally-acquired-images`: the dataset that was created to train segmentation models<br> - `trained-models`: contains five models trained on the trainind dataset to be used for predictions<br> - `segmentation-predictions-for-different-species`: segmentations based on a trained model on biofilms of different species<br> - `training-data-synthetic`: Synthetic microscope images and their corresponding label images together with scripts to create the data</p>
Resource availability and capacity to implement multi-stranded cholera interventions in the north-east region of Nigeria
<p>Limited healthcare facility (HCF) resources and capacity to implement multi-stranded cholera interventions ('water, sanitation, and hygiene (WASH)’, ‘surveillance’, ‘case management’, and ‘community engagement’) can hinder the actualisation of the global strategic roadmap goals for cholera control, especially in settings made fragile by armed conflicts, such as the north-east region of Nigeria. Therefore, we aimed to assess HCF resource availability and capacity to implement these cholera interventions in Adamawa and Bauchi States in Nigeria, as well as assess their coordination in both states and Abuja, where national coordination of cholera is based.<br> We conducted a cross-sectional survey using a face-to-face structured questionnaire to collect data on multi-stranded cholera interventions and their respective indicators in HCFs. We generated scores to describe the resource availability of each cholera intervention and categorised them as: 0-50 (low), 51-70 (moderate), 71-90 (high), and over 90 (excellent). Further, we defined an HCF with a high capacity to implement a cholera intervention as one with a score equal to or above the average intervention score. </p>
Data for: Constitutive expression of the Type VI secretion system carries no measurable fitness cost in Vibrio cholerae
Open the record for dataset details and reuse information.
Global Vibrio Cholerae O1 dataset
<p>This repository contains six files. Files with the n4196 file notation pertain the full core genome alignment, while the n100 FASTA file can be used for testing purposes. The files (.csv and .tsv) conains metadata of the sequences in the FASTA and tree files. Both core genome alignments (FASTA files) contain sequence outputs from SNIPPY and has not been processed through the clustering or masking steps in CholeraSeq. </p>
Supplementary Figures -B Cell Epitopes Mapping of the Vibrio cholera Toxins A, B, and P and an ELISA assay
<p>Figure S1- List of <em>Vibrio cholerae</em> [toxin A (P01555), B (P01556), and P (P29485)] synthetic peptides and position in the cellulose membrane of Spot synthesis.</p> <p>Figure S2- Purification of the peptide B (Vc/TxB-11) by HPLC using an XBridge BEH C18 (2.7 μ, 5 cm x 4.6 mm) column coupled to a Water HPLC system at a flow rate of 1.2 ml min<sup>-1 </sup>using mobile phases A [0.05% formic acid in water (18 MΩ × cm)] and B [(0.05% formic acid in ACN (acetonitrile acid)] (v/v) in water. Detection at 200-300 nm using a diode array.</p> <p>Figure S3- Mass spectrometry. The peptide B (Vc/TxB-11) was solubilized in deionized water to a final concentration of 10 µg/ml and then added formic acid to a final concentration of 0.1%. The mass spectrometer used was the Water UPLC model Acquity-I Class. The samples were electronically injected by the equipment at 1 µl/min. The range used for ion detection ranged from 1000-11500 m/z.</p>
Cholera Anti-Secretory Treatment Trial
ClinicalTrials.gov study NCT04150250. IPD Sharing: NO. Countries: 1. Publications: 1.
Immunologic Responses to a Live Attenuated Oral Cholera Vaccine
ClinicalTrials.gov study NCT03251495. IPD Sharing: NO. Countries: 1. Publications: 1.
Epidemiology Non-cholera Vibrio Infections
ClinicalTrials.gov study NCT04451707. IPD Sharing: YES. Countries: 1. Publications: 5.
Follow-up of Pregnant Women After a Mass Vaccination of Oral Cholera Vaccine (ShancholTM) in Nsanje Malawi
ClinicalTrials.gov study NCT02499172. IPD Sharing: Not stated. Countries: 1. Publications: 1.
A Study of Live Oral Cholera Vaccine, PXVX200 in Healthy Older Adults
ClinicalTrials.gov study NCT02100631. IPD Sharing: NO. Countries: 1. Publications: 1.
Safety and Efficacy Challenge Study of Live Oral Cholera Vaccine Candidate,PXVX0200, to Prevent Cholera
ClinicalTrials.gov study NCT01895855. IPD Sharing: NO. Countries: 1. Publications: 5.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.