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4,582 results for “chronic disease”
Exploring the Impact of Physiotherapy on Health Outcomes in Elderly Patients with Chronic Diseases: A Cross-Sectional Analysis
<p>In this cross-sectional analysis, we investigate the transformative impact of physiotherapy on health outcomes among elderly patients grappling with chronic diseases. Physiotherapy emerges as a pivotal intervention, offering multifaceted benefits that extend beyond mere symptom management. Through tailored exercises, mobility enhancements, and targeted pain management strategies, physiotherapy not only mitigates physical limitations but also fosters greater independence and quality of life. By examining a diverse cohort of elderly individuals diagnosed with chronic conditions such as osteoarthritis and cardiovascular diseases, this study underscores the profound role of physiotherapy in promoting functional mobility, reducing healthcare burdens, and enhancing overall well-being among this vulnerable population."</p>
Data from: Chronic Rapamycin administration via drinking water mitigates the pathological phenotype in a Krabbe disease mouse model through autophagy activation.
<p>ABSTRACT </p><p>Krabbe disease (KD) is a rare disorder caused by a deficiency of the lysosomal enzyme galactosylceramidase (GALC), resulting in the accumulation of the cytotoxic metabolite psychosine (PSY) in the nervous system. This accumulation triggers demyelination and neurodegeneration. Despite ongoing research, the underlying pathogenic mechanisms remain incompletely understood, and there is currently no cure available.</p><p>Previous studies from our lab revealed the presence of autophagy dysfunctions in KD pathogenesis, as evidenced by the presence of p62-tagged protein aggregates in the brains of KD mice and increased p62 levels in the KD sciatic nerve. We also demonstrated that the autophagy inducer Rapamycin (RAPA) can partially restore the wild-type (WT) phenotype in KD primary cells by reducing the number of p62 aggregates.</p><p>In this study, we tested RAPA in the Twitcher (TWI) mouse, a spontaneous KD mouse model. We administered the drug ad libitum via drinking water (15 mg/L) starting from post-natal day (PND) 21-23. We longitudinally monitored the motor performance of the mice through grip strength and rotarod tests, along with various biochemical parameters related to KD pathogenesis (i.e. autophagy markers expression, myelination, astrogliosis, and PSY accumulation).</p><p>Our findings demonstrate that RAPA significantly enhances motor functions at specific treatment time points and reduces astrogliosis in TWI brain, spinal cord, and sciatic nerves. Using western blot and immunohistochemistry, we observed a decrease in p62 aggregates in TWI nervous tissues, which corroborates our earlier in-vitro results. Furthermore, RAPA treatment partially reduces PSY levels in the spinal cord.</p><p>In conclusion, our results support the consideration of RAPA as a supportive therapy for KD. Importantly, as RAPA is already available in pharmaceutical formulations for clinical use, its potential for KD treatment can be promptly evaluated in clinical trials.</p>
Assessment of skin autofluorescence and its association with glycated hemoglobin, cardiovascular risk markers and concomitant chronic diseases in children with type 1 diabetes
<p>This is the dataset for the publication "Assessment of skin autofluorescence and its association with glycated hemoglobin, cardiovascular risk markers and concomitant chronic diseases in children with type 1 diabetes".</p>
Dataset for "Cognitive behavioural therapy self-help intervention preferences among informal caregivers of adults with chronic kidney disease: an online cross-sectional survey"
<p>Data and R code used for the analysis of data for the publication: Coumoundouros et al., Cognitive behavioural therapy self-help intervention preferences among informal caregivers of adults with chronic kidney disease: an online cross-sectional survey. BMC Nephrology</p> <p><strong>Summary of study</strong></p> <p>An online cross-sectional survey for informal caregivers (e.g. family and friends) of people living with chronic kidney disease in the United Kingdom. Study aimed to examine informal caregivers' cognitive behavioural therapy self-help intervention preferences, and describe the caregiving situation (e.g. types of care activities) and informal caregiver's mental health (depression, anxiety and stress symptoms).</p> <p>Participants were eligible to participate if they were at least 18 years old, lived in the United Kingdom, and provided unpaid care to someone living with chronic kidney disease who was at least 18 years old.</p> <p>The online survey included questions regarding (1) informal caregiver's characteristics; (2) care recipient's characteristics; (3) intervention preferences (e.g. content, delivery format); and (4) informal caregiver's mental health. Informal caregiver's mental health was assessed using the 21 item Depression, Anxiety, and Stress Scale (DASS-21), which is composed of three subscales measuring depression, anxiety, and stress, respectively.</p> <p>Sixty-five individuals participated in the survey.</p> <p>See the published article for full study details.</p> <p><strong>Description of uploaded files</strong></p> <p>1. ENTWINE_ESR14_Kidney Carer Survey Data_FULL_2022-08-30: Excel file with the complete, raw survey data. Note: the first half of participant's postal codes was collected, however this data was removed from the uploaded dataset to ensure participant anonymity.</p> <p>2. ENTWINE_ESR14_Kidney Carer Survey Data_Clean DASS-21 Data_2022-08-30: Excel file with cleaned data for the DASS-21 scale. Data cleaning involved imputation of missing data if participants were missing data for one item within a subscale of the DASS-21. Missing values were imputed by finding the mean of all other items within the relevant subscale. </p> <p>3. ENTWINE_ESR14_Kidney Carer Survey_KEY_2022-08-30: Excel file with key linking item labels in uploaded datasets with the corresponding survey question.</p> <p>4. R Code for Kidney Carer Survey_2022-08-30: R file of R code used to analyse survey data.</p> <p>5. R code for Kidney Carer Survey_PDF_2022-08-30: PDF file of R code used to analyse survey data.</p>
Supplementary material: Prophylactic antibiotics for adults with chronic obstructive pulmonary disease: a network meta-analysis
<p>Supplementary material for Cochrane review: Janjua S , Mathioudakis AG , Fortescue R , Walker RAE , Sharif S , Threapleton CJD , Dias S . Prophylactic antibiotics for adults with chronic obstructive pulmonary disease: a network meta-analysis. Cochrane Database of Systematic Reviews 2021, Issue 1. Art. No.: <a href="https://archie.cochrane.org/sections/documents/CD013198">CD013198</a>. DOI: <a href="https://archie.cochrane.org/sections/documents/10.1002/14651858.CD013198.pub2">10.1002/14651858.CD013198.pub2</a>.</p>
Experiment data in support of "Segmentation analysis and the recovery of queuing parameters via the Wasserstein distance: a study of administrative data for patients with chronic obstructive pulmonary disease"
<p>This archive contains a ZIP archive, `data.zip`, that itself contains the data used in the final sections of the paper. The remainder of the paper's supporting files are available at <a href="https://github.com/daffidwilde/copd-paper/">github.com/daffidwilde/copd-paper/</a></p> <p>The ZIP archive is structured as follows:</p> <ul> <li>There is a directory, `wasserstein`, for the parameter sweep described in the model construction section of the paper. Its contents are: (i) a file, `main.csv`, describing each parameter and their maximal Wasserstein distance to the observed data, and (ii) three directories, `best`, `median` and `worst`, each containing the simulated queuing results (in `main.csv`) from that sweep with the best, median and worst found parameter sets, respectively (in `params.txt`).</li> <li>The remaining three directories correspond to the experiments conducted in the final section of the paper. Each directory contains two files: (i) `system_times.csv` which holds trial parameters and system time records for every patient to pass through the model in that experiment, and (ii) `utilisations.csv` which holds trial parameters and utilisations for each server in the model for that experiment.</li> </ul>
An exposome atlas of serum reveals risk of chronic diseases in Chinese population
<p>Although adverse environmental exposures are considered to be a major cause to chronic diseases, current studies have provided limited knowledge on real-world chemical exposures and related risks. Here, we collected serum samples from 5696 healthy people and patients, including 12 chronic diseases in China, and completed serum biomonitoring containing 267 chemicals using gas and liquid chromatography-tandem mass spectrometry. 74 high-frequently detected exposures were used for exposure characterization and risk analysis. Results showed that region was the most critical factor influencing human exposure levels, followed by age. Organochlorine pesticides and perfluoroalkyl substances were associated with multiple chronic diseases, and some of them exceeded safe ranges. Mixture effect models showed significant risk effects of exposure on hyperlipidemia, metabolic syndrome and hyperuricemia. Overall, this study provided a comprehensive human serum exposure atlas and its disease risk, which could guide subsequent more in-depth cause-and-effect studies between environmental exposures and human health. The R codes and related example data for statistical analysis and figure production have been deposited to the GitHub (https://github.com/youlei2023/ExposomeAtlas).</p>
Outdoor air pollution impacts chronic obstructive pulmonary disease deaths in South Asia and China: a systematic review and meta-analysis
<p><strong>Background: </strong>Chronic obstructive pulmonary disease (COPD) is among leading causes of death globally. Exposure to outdoor pollution is an important cause for increased mortality and morbidity. This study presents a systemic review regarding the impact of outdoor pollution on COPD mortality in South Asia and China.</p> <p><strong>Methods: </strong>A systematic search was conducted from 1990 to June 30<sup>th</sup> 2020 in English electronic databases: PubMed, Google Scholar and CDSR (Cochrane Database of Systematic Reviews) following Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. The following terms were used: Chronic Obstructive Pulmonary disease OR COPD OR Chronic Bronchitis OR Emphysema OR COPD Deaths OR Chronic Obstructive Lung Disease OR Airflow Obstruction OR Chronic Airflow Obstruction OR Airflow Obstruction, Chronic OR Bronchitis, Chronic AND Mortality OR Death OR Deceased AND Outdoor pollution, ambient pollution was conducted.</p> <p><strong>Results:</strong> Out of 1899 papers screened only 17 were found eligible to be included. Subjects with COPD exposed to higher levels of outdoor air pollution had a 49% higher risk of death as compared to COPD subjects exposed to lower levels of outdoor air pollution. When taking common air pollutants individually into consideration, PM10 had an odds ratio (OR) of 1.99 respectively at CI 95%, whereas SO2 had OR of 1.8 at 95% CI, and NO2 had an OR of 1.23 OR at 95% CI. These values suggest that there is an effect of outdoor pollution on COPD but not to a significant level.</p> <p><strong>Conclusion: </strong>Despite heterogeneity across selected studies, individuals exposed to outdoor pollutants were found to be at risk of COPD mortality. Though it appears to have risk, COPD mortality was not significantly associated with outdoor pollutants. Controlling air pollution can substantially decrease the risk of COPD in South Asia and China. Further researches including more prospective and longitudinal studies are urgently needed in COPD sub-groups.</p>
Data from: The impact of long-term azithromycin on antibiotic resistance in HIV-associated chronic lung disease
<p><b>Background</b>: Selection for resistance to azithromycin (AZM) and other antibiotics such as tetracyclines and lincosamides remains a concern with long-term AZM use for treatment of chronic lung diseases (CLD). We investigated the impact of 48 weeks of AZM on the carriage and antibiotic resistance of common respiratory bacteria among children with HIV-associated CLD.</p> <p><b>Methods</b>: Nasopharyngeal (NP) swabs and sputa were collected at baseline, 48 and 72 weeks from participants with HIV-associated CLD randomised to receive weekly AZM or placebo for 48 weeks and followed post-intervention until 72 weeks. The primary outcomes were prevalence and antibiotic resistance of <i>Streptococcus pneumoniae</i> (SP), <i>Staphylococcus aureus </i>(SA), <i>Haemophilus influenzae </i>(HI), and <i>Moraxella catarrhalis </i>(MC) at these timepoints. Mixed-effects logistic regression and Fisher's exact test were used to compare carriage and resistance respectively.</p> <p><b>Results</b>: Of 347 (174 AZM, 173 placebo) participants (median age 15 years [IQR =13–18], females 49%),NP carriage was significantly lower in the AZM (n=159) compared to placebo (n=153) arm for SP (18% vs 41%, <i>p</i><0.001)<i>, </i>HI (7% vs 16%, p=0.01)<i>, </i>and MC (4% vs 11%, <i>p</i>=0.02); SP resistance to AZM (62% [18/29] vs 13%[8/63], <i>p</i><0.0001) or tetracycline (60%[18/29] vs 21%[13/63], <i>p</i><0.0001) were higher in the AZM arm. Carriage of SA resistant to AZM (91% [31/34] vs 3% [1/31],<i> p</i><0.0001), tetracycline (35% [12/34] vs 13% [4/31],<i> p</i>= 0.05) and clindamycin (79% [27/34] vs 3% [1/31],<i> p</i><0.0001) was also significantly higher in the AZM arm and persisted at 72 weeks. Similar findings were observed for sputa.</p> <p><b>Conclusions</b>: The persistence of antibiotic resistance and its clinical relevance for future infectious episodes requiring treatment needs further investigation.</p>
The efficacy of wildlife fences for keeping reindeer outside a chronic wasting disease risk area
<p>Data to</p> <p>"The efficacy of wildlife fences for keeping reindeer outside a chronic wasting disease risk area"</p> <p>accepted in Ecological Solutions and Evidence</p>
A network-based approach for isolating the chronic inflammation gene signatures underlying complex diseases towards finding new treatment opportunities
<p>This file contains the data that was used in the paper titled "A network-based approach for isolating the chronic inflammation gene signatures underlying complex diseases towards finding new treatment opportunities" which will be published in Frontiers of Pharmacology.</p>
Chronic wasting disease alters the movement behavior and habitat use of mule deer during clinical stages of infection
<p>Integrating host movement and pathogen data is a central issue in wildlife disease ecology that will allow for a better understanding of disease transmission. We examined how adult female mule deer (<em>Odocoileus hemionus</em>) responded behaviorally to infection with chronic wasting disease (CWD). We compared movement and habitat use of CWD-infected deer (<em>n</em> = 18) to those that succumbed to starvation (and were CWD-negative by ELISA and IHC; <em>n</em> = 8) and others in which CWD was not detected (<em>n</em> = 111, including animals that survived the duration of the study) using GPS collar data from two distinct populations collared in central Wyoming, USA during 2018–2022. CWD and predation were the leading causes of mortality during our study (32 of 91 deaths attributed to CWD and 27 of 91 deaths attributed to predation). Deer infected with CWD moved slower and used lower elevation areas closer to rivers in the months preceding death compared with uninfected deer that did not succumb to starvation. Although CWD-infected deer and those that died of starvation moved at similar speeds during the final months of life, CWD-infected deer used areas closer to streams with less herbaceous biomass than deer that died of starvation. These behavioral differences may allow for the development of predictive models of disease status from movement data, which will be useful to supplement field and laboratory diagnostics or when mortalities cannot be quickly retrieved to assess cause-specific mortality. Furthermore, identifying individuals that are sick before predation events could help to assess the extent to which disease mortality is compensatory with predation. Finally, infected animals began to slow down around four months prior to death from CWD. Our approach for detecting the timing of infection-induced shifts in movement behavior may be useful in application to other disease systems to better understand the response of wildlife to infectious disease.</p>
Fig. 1 in Apparent effect of chronic Plasmodium infections on disease severity caused by experimental infections with Mycoplasma gallisepticum in house finches
Fig. 1. Mean severity of eye lesions ± SE (circles), and M. gallisepticum-load (log (qPCR+1)) (triangles) of birds infected through horizontal transmission with the CA2015 strain of M. gallisepticum. Birds in which Plasmodium was detected by PCR (grey symbols) developed more severe disease than birds in which Plasmodium was not found (white symbol). As there is no significant interaction between M. gallisepticum ‾strain and Plasmodium infection (Table 2) the results for the other M. gallisepticum strains are qualitatively similar and therefore not shown.
Data files for manuscript "Prevalence of hereditary tubulointerstitial kidney diseases in the German Chronic Kidney Disease study"
<p>#2021-09-19<br> #Summary<br> This ZIP-file contains the Excel files used for all analyses for the manuscript "Prevalence of hereditary tubulointerstitial kidney diseases in the German Chronic Kidney Disease study".</p> <p><br> #File structure<br> README.txt This README file.<br> File S1 ("FileS1_GCKD-ADTKD.cohort.xlsx") Cohort characteristics, sequencing quality parameters and fingerprinting results.<br> File S2 ("FileS2_GCKD-ADTKD.content.xlsx") Sequencing panel design/ content with information on gene domains used for Figure 2.<br> File S3 ("FileS3_GCKD-ADTKD.variants.xlsx") Information on small variants, CNVs and MUC1 analyses (SNaPshot and adVNTR).<br> File S4 ("FileS4_GCKD-ADTKD.simulation.xlsx") Curated variant and individual data from the Groopman study with results of the simulation for Figure 4.</p> <p><br> #Files and checksums<br> 2D6184BC145987D3EE2E0DC6873DDDDB ./README.txt<br> 10EE4C3C9D9ED6417647F26A09583820 ./FileS1_GCKD-ADTKD.cohort.xlsx<br> 9F95661845215FB7875EB053F887AB36 ./FileS2_GCKD-ADTKD.content.xlsx<br> 2AC19FBC6103CB48905F64716428AE5B ./FileS3_GCKD-ADTKD.variants.xlsx<br> 2D6184BC145987D3EE2E0DC6873DDDDB ./FileS4_GCKD-ADTKD.simulation.xlsx</p>
Data from: Age estimation using methylation-sensitive high-resolution melting (MS-HRM) in both healthy felines and those with chronic kidney disease
<p>Age is an important ecological tool in wildlife conservation. However, it is difficult to estimate in most animals, including felines — most of whom are endangered. Here, we developed the first DNA methylation-based age-estimation technique — as an alternative to current age-estimation methods — for two feline species that share a relatively long genetic distance with each other: domestic cat (<i>Felis catus</i>; 79 blood samples) and an endangered <i>Panthera</i>, the snow leopard (<i>Panthera uncia</i>; 11 blood samples). We measured the methylation rates of two gene regions <span>using </span>methylation-sensitive high-resolution melting (MS-HRM). Domestic cat age was estimated with a mean absolute deviation (MAD) of 3.83 years. Health conditions influenced accuracy of the model. Specifically, the models built on cats with chronic kidney disease (CKD) had lower accuracy than those built on healthy cats. The snow leopard-specific model (i.e. the model that resets the model settings for snow leopards) had a better accuracy (MAD = 2.10 years) than that obtained on using the domestic cat model directly. This implies that our markers could be utilised across species, although changing the model settings when targeting different species could lead to better estimation accuracy. The snow leopard-specific model also successfully distinguished between sexually immature and mature individuals.</p>
Innovation in chronic respiratory diseases: biodiversity and commons – WHO GARD workshop [video]
<p>00:00 Introduction by Letitia Harding.</p> <p>00:15 Embedding biodiversity in digitally-enabled, patient-centered care pathways for airway diseases – Dr Jean Bousquet.</p> <p>09:35 Open-source respiratory health commons. 15 projects communities can adapt, repair, reproduce for low cost medical care (libre and open-source tech) [<a href="https://doi.org/10.5281/zenodo.5515632">download presentation</a>].</p> <p>18:13 Open discussion – Facilitation by Letitia Harding.</p> <p>28:56 End.</p>
Statistics "Bioderived therapeutics for chronic liver diseases"
<p>Details to the statistics for the chapter 4 in the thesis "Bioderived therapeutics for chronic liver diseases"</p>
Fig. 1 in Infection with Toxoplasma gondii can promote chronic liver diseases in HIV-infected individuals
Fig. 1. Frequency of different liver pathologies in deceased patients from cohorts seropositive and seronegative to Toxoplasma gondii (Nicolle et Manceaux, 1908). * – difference between the indices for the entire cohort of seropositive patients and for the group of deceased patients from this cohort (p <0.05); ^ – difference between the indices for the entire cohort of seronegative patients and for the group of deceased patients from this cohort (p <0.05)
Safety and Efficacy Study of AB023 (Xisomab 3G3) in End Stage Renal Disease Patients on Chronic Hemodialysis
ClinicalTrials.gov study NCT03612856. IPD Sharing: YES. Countries: 1. Publications: 2.
Safety and Efficacy Study of AB002 (E-WE Thrombin) in End Stage Renal Disease Patients on Chronic Hemodialysis
ClinicalTrials.gov study NCT03963895. IPD Sharing: YES. Countries: 1. Publications: 2.
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.