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322 results for “chronic stress”
Dataset-Response strategies to acute and chronic environmental stress in the arctic breeding Lapland longspur (Calcarius lapponicus)
<p>This is the dataset presenting the phenotypic measurements in the paper Response strategies to acute and chronic environmental stress in the arctic breeding Lapland longspur (<em>Calcarius lapponicus</em>).</p>
Figure 4 in Chronic stress from fishing gear entanglement is recorded in baleen from a bowhead whale (Balaena mysticetus)
Figure 4. Glucocorticoid hormone profile in baleen from entangled bowhead whale 17B6. Baleen GC concentrations (ng/g) are shown as red circles for cortisol and orange circles for corticosterone. Sample dates were estimated based on an annual baleen growth rate of 17.5 cm/yr, starting with the harvest date (5 May 2017) on the right side of the bottom x-axis and extending retrospectively to approximately November 2005 on the left side of the x-axis (tick marks are months). Sampling locations along the baleen plate are shown on the top x-axis, and background gridlines represent the 1.25 or 2.5 cm sampling intervals used, starting at the plate base.
Figure 3. The first 10 in Chronic stress from fishing gear entanglement is recorded in baleen from a bowhead whale (Balaena mysticetus)
Figure 3. The first 10 cm of the baleen plate from bowhead whale 17B6 showing a measuring tape attached to the labial margin of the plate to guide sampling intervals. Samples were drilled every 1.25 cm (~26 d intervals) across the horizontal growth lines along the plate for the first 35 cm of growth to maximize the possibility of capturing data on the entanglement event from more recent baleen growth, and every 2.5 cm (~52 d intervals) for the reminder of the plate to establish baseline levels of GCs prior to the entanglement. Samples were collected using a hand-held Dremel rotary tool to produce pulverized baleen powder for glucocorticoid hormone analysis.
Figure 2. Fishing rope recovered from bowhead whale 17B6 in Chronic stress from fishing gear entanglement is recorded in baleen from a bowhead whale (Balaena mysticetus)
Figure 2. Fishing rope recovered from bowhead whale 17B6 included two types of 19 mm diameter rope. Segment (#1) appeared to be white nylon rope, while segments (#s 2, 4, 5) were blue-flecked and most likely a copolymer rope. Segment (#3) was line used by the hunters during the harvest and was not part of the whale entanglement. Fraying of the rope ends was consistent with cut ends that had not been heat sealed or whipped. It was not possible to determine the status of the gear at the time of entanglement.
Figure 1. Entangled bowhead whale 17B6 in Chronic stress from fishing gear entanglement is recorded in baleen from a bowhead whale (Balaena mysticetus)
Figure 1. Entangled bowhead whale 17B6. (A) 17B6 appeared quite thin in the posterior region, and had six full wraps of fishing line around the peduncle (white circle). (B) Close-up of the peduncle of 17B6 showing the embedded fishing line. Photo credits: North Slope Borough Department of Wildlife Management, taken under NMFS permit # 17350-01.
Behavioral effects of chronic stress in Carioca High- and Low-conditioned Freezing rats
<p><span>Chronic unpredictable mild stress (CUMS) is a widely used model to study stress-coping strategies in rodents. Different factors have been shown to influence whether animals adopt passive or active coping responses to CUMS. Individual adaptation and susceptibility to the environment seem to play a critical role in this process. To further investigate this relationship, we examined the effects of CUMS on Carioca high- and low-conditioned freezing rats (CHF and CLF, respectively), bidirectional lines of animals selected for high and low freezing in response to contextual cues that were previously associated with footshocks. For this purpose, the behavior of CHF and CLF animals was evaluated in the contextual fear conditioning, open field, elevated T maze, and forced swimming tests before and after 21 days of CUMS. Animals kept under standard housing conditions were used as controls. For all tests, CHF rats were more susceptible to the effects of CUMS compared to CLF and control groups. CHF animals exposed to CUMS displayed a reduction in freezing behavior, decreased number of entries and time spent in the center of the open field, greater latencies to become immobile, and increased avoidance and escaping behaviors in the elevated T maze. Overall, these findings support the hypothesis that a heightened susceptibility to the environment exerts a strong influence on coping responses to chronic stress.</span></p>
Additional raw video and pose estimation data of top view mouse behavior recordings (marble burying test, light-dark box, fear conditioning box) of acute and chronic stress models
<p>This repository contains raw data for 296 different behavioral recordings of mice (marble burying test, light-dark box, fear conditioning box). These include top view raw video .mp4 files (Videos.zip) and the corresponding .csv pose estimation data (data.zip) obtained with DeepLabCut. The data is from multiple different experiments. The METADATA.csv or METADATA.xlsx files contain all grouping variables and help linking the pose estimation files (located in multiple subfolders of /data) to the video files. Visit https://github.com/ETHZ-INS/BehaviorFlow to find out more about how this data has be used by us.</p>
Chronic social defeat stress induces meningeal neutrophilia via type I interferon signaling: single cell RNA sequencing data
<p>Meningeal single cell RNA sequencing data</p> <p>Meningeal samples were collected from both dorsal and ventral skull, avoiding inclusion of choroid plexus. Samples were digested in 2.5 mg/mL Collagenase D (Cat. #11088858001; Roche) and 12.5 μL of 0.5 mg/mL DNAseI (Cat. #L5002139; Worthington), put on a shaker at 370C for 30 m, diluted with cold HBSS + 0.1% BSA, and mashed through a 70 μm cell strainer prior to sorting.</p> <p>Data represent live, nucleated, singlet cells (DAPI-DRAQ5+) sorted on a BD FACS Aria Fusion into HBSS + 10% FBS prior to droplet encapsulation using 10x Genomics’ Drop-seq platform (Chromium v2).</p> <p>10X chip lane is indicate by 'group' column</p> <p>Group 1 = 4 pooled homecage control (unstressed) mice</p> <p>Group 2 = 4 pooled homecage control (unstressed) mice</p> <p>Group 3 = 4 pooled mice exposed to chronic social defeat for 14 days; tissue was collected 2 hours following final defeat</p> <p>See the following repositories for data processing:</p> <p><a href="https://github.com/maryellenlynall/2019_bcell_stress/blob/master/bcellstress20.Rmd">https://github.com/maryellenlynall/2019_bcell_stress/</a> (processing from raw files starts at bcellstress020.Rmd)</p> <p><a href="https://github.com/staceykigar/meningeal_neut/">https://github.com/staceykigar/meningeal_neut/</a></p> <p>We also provide a processed dataset (processed.RData) with assays 'counts' and 'logcounts' which is the processed single cell object saved at line "# Save object for upload to Zenodo" in script <a href="https://github.com/staceykigar/meningeal_neut/">https://github.com/staceykigar/meningeal_neut/</a>neutrophilstress01.Rmd </p> <p>Cluster annotations are in sce$Annotation</p> <p>Neutrophil subcluster annotations are in sce$Subcluster</p> <p>Sample condition is in sce$cond, where "HC" indicates homecage control and "SD" indicates chronic social defeat</p> <p>10X chip lane is in sce$group</p>
Table 1 in Chronic stress from fishing gear entanglement is recorded in baleen from a bowhead whale (Balaena mysticetus)
<p><i>Table 1.</i> The mean (± SD), baseline (± SD), and maximum values for cortisol and corticosterone measured in baleen from a severely entangled bowhead whale (17B6) compared to healthy subadult (<i>n</i> = 3) and adult (<i>n</i> = 4) male bowhead whales. The mean and baseline values for 17B6 were calculated using data from the preentanglement period, and the values are identical because there were no outlier values (see Methods for details).</p><table><tbody><tr><th></th><th>Cortisol (ng/g)</th><th></th><th>Corticosterone (ng/g)</th></tr></tbody><tbody><tr><th></th><td>Mean</td><td>Baseline</td><td>Maximum</td><td>Mean</td><td>Baseline</td><td>Maximum</td></tr><tr><th>Entangled</th><td>0.15 ± 0.06</td><td>0.15 ± 0.06</td><td>3.23</td><td>0.53 ± 0.17</td><td>0.53 ± 0.17</td><td>1.14</td></tr><tr><th>Subadults</th><td>0.52 ± 0.24</td><td>0.49 ± 0.12</td><td>1.60</td><td>1.06 ± 0.57</td><td>1.02 ± 0.25</td><td>2.70</td></tr><tr><th>Adults</th><td>0.35 ± 0.09</td><td>0.32 ± 0.04</td><td>1.11</td><td>0.75 ± 0.22</td><td>0.74 ± 0.13</td><td>1.67</td></tr></tbody></table>
Traumatic events, post-traumatic stress disorder, and proxy measures for central sensitization in chronic pain patients of a German university outpatient pain clinic
<p>This dataset was acquired at Hannover Medical School, Hannover, Germany. The study complied with the Declaration of Helsinki, and was approved by the local ethics committee. All subjects gave written informed consent, and consent to use their data anonymously for research purposes. The study was registered at ClinicalTrials.gov (NCT05190367).</p> <p>Between February 2019 and July 2020, 914 patients who visited our outpatient pain department gave written consent to use their routinely collected data anonymously for research purposes. Participants were divided into four groups depending on their trauma severity: (1) no trauma; (2) accidental trauma (e.g. illness, accident, natural disaster); (3) interpersonal trauma (e.g. assault, rape, war); (4) PTSD (diagnosed according to ICD-10). Patients fulfilling two or more categories were assigned to the highest group.</p> <p>Data were collected using the SymptomMapper application [1]. Participants provided information about their traumas, current pain intensity (visual analogue scale, VAS (0-100) [2]), mean and maximal pain in the last 4 weeks (VAS (0-100)), sleep impairment (VAS (0-100)), acceptable pain (VAS (0-100)), pain disability index (PDI [3]), pain area (digital drawings), pain widespreadness (widespread pain index, WPI [4], derived from drawings), stress (patient health questionnaire, German version, PHQ-D [5]), anxiety (PHQ-D), depression (PHQ-D), and somatization symptoms (PHQ-D).</p> <p>This dataset contains the raw data as well as necessary scripts for reproducing the results of this study.</p> <p> </p> <p>References<br> ##########</p> <p>[1] Neubert TA, Dusch M, Karst M, Beissner F. Designing a Tablet-Based Software App for Mapping Bodily Symptoms: Usability Evaluation and Reproducibility Analysis. JMIR Mhealth Uhealth 2018;6(5):e127.<br> [2] Dworkin RH, Turk DC, Farrar JT et al. Core outcome measures for chronic pain clinical trials: IMMPACT recommendations. Pain 2005;113(1):9-19.<br> [3] Pollard CA. Preliminary Validity Study of the Pain Disability Index. Percept Mot Skills 1984;59(3): 974.<br> [4] Wolfe F, Clauw DJ, Fitzcharles MA et al. The American College of Rheumatology Preliminary Diagnostic Criteria for Fibromyalgia and Measurement of Symptom Severity. Arthritis Care Res 2010;62(5):600-10.<br> [5] Löwe B, Spitzer RL, Zipfel S, Herzog W. Gesundheitsfragebogen für Patienten (PHQ-D). Manual und Testunterlagen (second edition). Pfizer 2002.</p>
Data for: Chronic stress hinders sensory axon regeneration via impairing mitochondrial cristae and OXPHOS
<p>Spinal cord injury (SCI) often leads to physical limitations, chronic pain, significant life changes, and social isolation, increasing the risk of chronic psychological stress such as anxiety and depression. Despite the recognition of the negative effects of chronic stress on SCI recovery, the mechanisms linking stress and regeneration are not fully understood. In this study, we examined the impact of chronic stress on primary sensory axon regeneration in a mouse model of preconditioning lesions. Our findings showed that chronic stress caused mitochondrial damage and energy crisis within primary sensory neurons, hindering the regrowth of their central axons. The stress hormone corticosterone was identified as a critical factor in this process, impacting satellite glial cells instead of neurons by suppressing Kir4.1 expression and leading to increased neuronal hyperactivity and elevated ROS levels. These high levels of ROS altered the shape of the mitochondrial cristae and disrupted ATP production, which is essential for powering axonal regeneration. Our results highlight the importance of addressing psychological stress in SCI patients to promote sensory-motor rehabilitation.</p>
Raw video and pose estimation data of top view open field mouse behavior recordings of acute and chronic stress models
<p>This repository contains raw data for 411 different open field recordings of mice. these include top view raw video .mp4 files (Videos.zip) and the corresponding .csv pose estimation data (data.zip) obtained with DeepLabCut. The data is from multiple different experiments. The METADATA.csv or METADATA.xlsx files contain all grouping variables and help linking the pose estimation files (located in multiple subfolders of /data) to the video files. Visit https://github.com/ETHZ-INS/BehaviorFlow to find out more about how this data has be used by us.</p>
Impact of prolonged chronic social isolation stress on behavior and multifractal complexity of metabolic rate in Octodon degus
<p>We investigated the effects of prolonged chronic social isolation stress on behavioral, cognitive, and physiological performance in the social, long-lived rodent <em>Octodon degus</em>. Degu pups were separated into two social stress treatments: control (CTRL) and chronically isolated (CI) individuals from post-natal and post-weaning until adulthood. We quantified anxiety-like behavior and cognitive performance with behavioral tests. Additionally, we measured their basal metabolic rate (BMR). Data include behavioral tests and physiological traits (body mass and Basal Metabolic Rate).</p>
Association Between Increased Oxidative Stress, Anti-Inflammatory Fatty Acid Formation, and Airway Infection in People With Asthma and Chronic Obstructive Pulmonary Disease
ClinicalTrials.gov study NCT00595114. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Intensive Treatment for Chronic Pain and Posttraumatic Stress Disorder (PTSD)
ClinicalTrials.gov study NCT01120067. IPD Sharing: NO. Countries: 1. Publications: 1.
Patient-Partner Stress Management Effects on Chronic Fatigue Syndrome Symptoms and Neuroimmune Process
ClinicalTrials.gov study NCT01650636. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Effectiveness of Three Different Psychotherapies for Chronic Post-Traumatic Stress Disorder
ClinicalTrials.gov study NCT00739765. IPD Sharing: NO. Countries: 1. Publications: 16.
Effects of Online Mindfulness Therapy on Pain and Stress in Adults With Chronic Migraine and Adverse Childhood Experiences
ClinicalTrials.gov study NCT07033520. IPD Sharing: NO. Countries: 1. Publications: 5.
Treatment of Older Veterans With Chronic Posttraumatic Stress Disorder
ClinicalTrials.gov study NCT00539279. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Efficacy and Safety of Gefapixant (MK-7264) in Women With Chronic Cough and Stress Urinary Incontinence (MK-7264-042)
ClinicalTrials.gov study NCT04193176. IPD Sharing: YES. Countries: 12. Publications: 1.
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International Brain Laboratory public data
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OpenNeuro
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