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4 results for “clathrin mediated endocytosis”
Data from: The clathrin adaptor complex AP-2 mediates endocytosis of BRASSINOSTEROID INSENSITIVE1 in Arabidopsis
Clathrin-mediated endocytosis (CME) regulates many aspects of plant development, including hormone signaling and responses to environmental stresses. Despite the importance of this process, the machinery that regulates CME in plants is largely unknown. In mammals, the heterotetrameric ADAPTOR PROTEIN COMPLEX-2 (AP-2) is required for the formation of clathrin-coated vesicles at the plasma membrane (PM). Although the existence of AP-2 has been predicted in Arabidopsis thaliana, the biochemistry and functionality of the complex is still uncharacterized. Here, we identified all the subunits of the Arabidopsis AP-2 by tandem affinity purification and found that one of the large AP-2 subunits, AP2A1, localized at the PM and interacted with clathrin. Furthermore, endocytosis of the leucine-rich repeat receptor kinase, BRASSINOSTEROID INSENSITIVE1 (BRI1), was shown to depend on AP-2. Knockdown of the two Arabidopsis AP2A genes or overexpression of a dominant-negative version of the medium AP-2 subunit, AP2M, impaired BRI1 endocytosis and enhanced the brassinosteroid signaling. Our data reveal that the CME machinery in Arabidopsis is evolutionarily conserved and that AP-2 functions in receptor-mediated endocytosis.
Data for: Intersectin1 promotes clathrin-mediated endocytosis by organizing and stabilizing endocytic protein interaction networks
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Raw data for Jin et. al "Intersectin1 promotes clathrin-mediated endocytosis by organizing and stabilizing endocytic protein interaction networks"
<h2><strong><span>Intersectin1 promotes clathrin-mediated endocytosis by organizing and stabilizing endocytic protein interaction networks</span></strong></h2> <p><span> </span></p> <p><span>Meiyan Jin<sup>1,2*</sup>, Yuichiro Iwamoto<sup>1</sup>, Cyna Shirazinejad<sup>1</sup>, David G. Drubin<sup>1,3**</sup></span></p> <p><sup><span>1 </span></sup><span>Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA</span></p> <p><sup><span>2</span></sup><span> Current Address: Department of Biology, University of Florida, Gainesville, Fl 32611, USA</span></p> <p><sup><span>3</span></sup><span> Lead author</span></p> <p><sup><span>* </span></sup><span>Correspondence: meiyan.jin@ufl.edu</span></p> <p><sup><span>**</span></sup><span>Correspondence: </span><span>drubin@berkeley.edu</span></p>
Data from: The clathrin adaptor complex AP-2 mediates endocytosis of BRASSINOSTEROID INSENSITIVE1 in Arabidopsis
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