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Row data for the experiment: "Clinical, psychosocial and demographic factors affect decisions in SLE people".
<p>These datasets correspond to the article titled: “Clinical, psychosocial and demographic factors affect decisions in SLE people”, which can be found at <a href="https://www.medrxiv.org/content/10.1101/2024.03.25.24304643v1.full.pdf">https://www.medrxiv.org/content/10.1101/2024.03.25.24304643v1.full.pdf</a></p> <p>Analysis scripts, and an explanation of variables, can be found at: <a href="https://github.com/NeuroGenomicsMX/Factors_affecting_decisions_in_SLE">https://github.com/NeuroGenomicsMX/Factors_affecting_decisions_in_SLE</a></p> <p>Abstract</p> <p><span>Neurological and psychiatric manifestations affect most lupus individuals and include depression, anxiety, mood disorders, and cognitive dysfunction. Although there is evidence supporting suboptimal decision-making in lupus and its association with glucocorticoids consumption, it is not clear what variables impact such decisions. The aim of this study is to explore how social, clinical, psychological, and demographic factors impact social and temporal decision-making in people with lupus. Through a within-subjects experimental-design, our participants responded to social, clinical, psychological, and demographic electronic questionnaires. Then, they participated in two behavioral economics experiments: the third-party dictator game, and the delay discounting task. Our results show that hostility, and age are essential predictors of social decisions, whereas obsessive-compulsiveness and anxiety better predict temporal decisions. These variables behave as expected, but anxiety shows unexpected results: most anxious people act patiently and prefer delayed but bigger rewards. Finally, clinical factors are critical decision predictors for social and temporal decisions. When people are in remission, they tend to impose higher punishment on those who violate the social norm, and they also tend to prefer immediate rewards. When taking glucocorticoids, they also prefer immediate rewards, and as the dosage of glucocorticoids intake increases, they tend to impose higher punishment on norm violators. Clinicians, researchers, and practitioners must consider the side effects of glucocorticoids on decision-making.</span></p>
Dataset Clinical Epilepsy iEEG to BIDS -RESPect_intraoperative_iEEG
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Dataset Clinical Epilepsy iEEG to BIDS - RESPect_longterm_iEEG
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HOSENG trial – HOme-based oral SElf-testiNG for absent and refusing individuals during a door-to-door HIV testing campaign: a cluster randomised clinical trial in rural Lesotho
<p>These are pseudo-anonymised data from the HOSENG randomized trial: " HOSENG trial – HOme-based oral SElf-testiNG for absent and refusing individuals during a door-to-door HIV testing campaign: a cluster randomised clinical trial in rural Lesotho". The data dictionary explains the data available in the dataset. Between July 2018 and December 2018, 10516 eligible individuals from 106 consenting villages were enrolled from two districts of Lesotho, and followed up for a maximum of 120 days. Main manuscript reference, DOI: <a href="https://doi.org/10.1016/s2352-3018(20)30233-2">10.1016/S2352-3018(20)30233-2. </a>The protocol was published, DOI:10.1186/s13063-019-3469-2.</p>
Dataset for the IntoValue 1 + 2 studies on results dissemination from clinical trials conducted at German university medical centers completed between 2009 and 2017
<p>The IntoValue dataset contains clinical trials conducted at one of 35 German UMCs and registered on ClinicalTrials.gov or the German Clinical Trials Registry (DRKS). All trials were reported as complete between 2009 and 2017 on the trial registry at the time of data collection. The dataset also includes a results publication found via manual searches; if multiple results publications were found, the earliest was included.</p> <p>Trials were associated with a German UMC by searching for trials with a UMC listed as responsible party or lead sponsor, or with a principle investigator (PI) from a UMC ('lead_city'). Version 1 additionally includes trials with a UMC only as a facility (`facility_city`). A lookup table of regular expressions used to identify German UMCs is available at <a href="https://github.com/quest-bih/IntoValue2/blob/master/data/1_sample_generation/city_search_terms.csv">https://github.com/quest-bih/IntoValue2/blob/master/data/1_sample_generation/city_search_terms.csv</a>.</p> <p>Trials include all interventional studies and are not limited to investigational medical product trials, as regulated by the EU's Clinical Trials Directive or Germany's Arzneimittelgesetz (AMG) or Novelle des Medizinproduktegesetzes (MPG).</p> <p>DRKS data were searched (pre-filtered for completion years and study status as well as Germany as 'Country of recruitment') and downloaded as CSVs from the DRKS website (<a href="https://www.drks.de/">https://www.drks.de/</a>). ClinicalTrials.gov data were downloaded downloaded as pipe files from Clinical Trials Transformation Initiative (CTTI) Aggregate Content of ClinicalTrials.gov (AACT) (<a href="https://aact.ctti-clinicaltrials.org/pipe_files">https://aact.ctti-clinicaltrials.org/pipe_files</a>). DRKS and ClinicalTrials.gov use different terminology for various trial aspects, such as phase and masking; these different levels are captured in the data dictionary as `levels_drks` and `levels_ctgov`. For later analyses requiring parity across registries, levels for some variables were collapsed and a lookup table is provided in `iv_data_lookup_registries.csv`.</p> <p>These data were generated and used for two publications (Wieschowski et al., 2019; Riedel et al. 2021) and therefore comprises two versions (indicated as `iv_version`).</p> <p>For version 1, registry data was collected on April 17, 2017 from ClinicalTrials.gov and on July 27, 2017 for DRKS and was limited to trials with a completion date on DRKS and primary completion date on ClinicalTrials.gov between 2009 and 2013. Version 1 manual searches for results publications were conducted from 2017-07-01 to 2017-12-01.<br> For version 2, registry data was collected on June 3, 2020 and was limited to trials with a completion date on DRKS and ClinicalTrials.gov between 2014 and 2017. Version 2 manual searches for results publications were conducted from 2020-07-01 to 2020-09-01.</p> <p>Raw registry data for versions 1 and 2 is available in `raw-registries.zip`.</p> <p>Publication identifiers (DOI, PMID, URL) were manually entered during the publication search and then further enhanced using the API of Internet Archive's open-source Fatcat catalog of research publications, to add PMIDs based on DOIs, and vice versa.</p> <p>Manual search steps differed slightly in the two versions and are indicated and described in `identification_step`.<br> Version 1 includes trials with a German UMC as either a `lead_city` or a `facility_city`, whereas version 2 is limited to trials a German UMC as a `lead_city`.</p> <p>Each row indicates a single trial registration. Due to changes in completion dates, some trials are duplicated between versions as indicated in `is_dupe`. Cross-registered trials were manually deduplicated, and some cross-registered duplicates remain (e.g., DRKS00004156 and NCT00215683) and are not indicated in the dataset.</p> <p>All dates are provided as `yyyy-mm-dd`.</p> <p>Additional documentation on each variable (type, description, levels) is provided in `iv_data_dictionary.csv`.</p> <p>Additional information on the project and methods for generating the dataset is available in associated publications and at the project's OSF page (<a href="https://osf.io/98j7u/">https://osf.io/98j7u/</a>). Code for the project is available at <a href="https://github.com/quest-bih/IntoValue2">https://github.com/quest-bih/IntoValue2</a>.</p> <p><strong>References:</strong></p> <p>Wieschowski, S., Riedel, N., Wollmann, K., Kahrass, H., Müller-Ohlraun, S., Schürmann, C., Kelley, S., Kszuk, U., Siegerink, B., Dirnagl, U., Meerpohl, J., & Strech, D. (2019). Result dissemination from clinical trials conducted at German university medical centers was delayed and incomplete. Journal of Clinical Epidemiology, 115, 37–45. <a href="https://doi.org/10.1016/j.jclinepi.2019.06.002">https://doi.org/10.1016/j.jclinepi.2019.06.002</a></p> <p>Riedel, N., Wieschowski, S., Bruckner, T., Holst, M. R., Kahrass, H., Nury, E., Meerpohl, J. J., Salholz-Hillel, M., & Strech, D. (2021). Results dissemination from completed clinical trials conducted at German university medical centers remained delayed and incomplete. The 2014-2017 cohort. Journal of Clinical Epidemiology, 0(0). <a href="http://doi.org/10.1016/j.jclinepi.2021.12.012">https://doi.org/10.1016/j.jclinepi.2021.12.012</a><br> </p>
Dataset of Pedigree, genotypes, clinical and biochemical characteristics of families of Northeastern Mexico
<p>This dataset combines pedigree, genotypes, clinical and biochemical data of 37 families of Northeastern Mexico. Primary reference is the article:</p> <p>Gallardo‑Blanco, H.L., Villarreal‑Perez, J.Z., Cerda‑Flores, R.M., Figueroa, A., Sanchez‑Dominguez, C.N., Gutierrez‑Valverde, J.M. ... Martinez‑Garza, L.E. (2017). Genetic variants in KCNJ11, TCF7L2 and HNF4A are associated with type 2 diabetes, BMI and dyslipidemia in families of Northeastern Mexico: A pilot study. Experimental and Therapeutic Medicine, 13, 523-529. https://doi.org/10.3892/etm.2016.3990</p> <p><strong>If you use these data please cite the corresponding manuscript, which can be downloaded here:</strong></p> <p>https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5348709/</p> <p>https://www.spandidos-publications.com/10.3892/etm.2016.3990</p> <p>This dataset contains genotypes for the following SNPs:</p> <p>rs2986742</p> <p>rs4846051</p> <p>rs1801131</p> <p>rs1801133</p> <p>rs6541030</p> <p>rs12130799</p> <p>rs11208654</p> <p>rs1137100</p> <p>rs12405556</p> <p>rs3118378</p> <p>rs3737576</p> <p>rs10923931</p> <p>rs7554936</p> <p>rs3737787</p> <p>rs2516839</p> <p>rs1040404</p> <p>rs4670767</p> <p>rs7578597</p> <p>rs13400937</p> <p>rs10496971</p> <p>rs2627037</p> <p>rs1801262</p> <p>rs1569175</p> <p>rs2975760</p> <p>rs3792267</p> <p>rs10510228</p> <p>rs1801282</p> <p>rs3856806</p> <p>rs4955316</p> <p>rs9809104</p> <p>rs4607103</p> <p>rs6548616</p> <p>rs734873</p> <p>rs5400</p> <p>rs2030763</p> <p>rs4402960</p> <p>rs1513181</p> <p>rs9291090</p> <p>rs10010131</p> <p>rs10007810</p> <p>rs385194</p> <p>rs1799883</p> <p>rs2504853</p> <p>rs7754840</p> <p>rs7745461</p> <p>rs1800750</p> <p>rs1800629</p> <p>rs361525</p> <p>rs12200998</p> <p>rs2397060</p> <p>rs192655</p> <p>rs1044498</p> <p>rs4463276</p> <p>rs731257</p> <p>rs864745</p> <p>rs32314</p> <p>rs2330442</p> <p>rs4717865</p> <p>rs3173798</p> <p>rs10954737</p> <p>rs854555</p> <p>rs3917542</p> <p>rs662</p> <p>rs705308</p> <p>rs3943253</p> <p>rs751141</p> <p>rs1471939</p> <p>rs12544346</p> <p>rs13266634</p> <p>rs7844723</p> <p>rs2242103</p> <p>rs1408801</p> <p>rs10811661</p> <p>rs10511828</p> <p>rs12779790</p> <p>rs3793791</p> <p>rs4746136</p> <p>rs1111875</p> <p>rs10885390</p> <p>rs11196175</p> <p>rs7903146</p> <p>rs10885406</p> <p>rs12255372</p> <p>rs290487</p> <p>rs4918842</p> <p>rs2237892</p> <p>rs10839880</p> <p>rs1837606</p> <p>rs5210</p> <p>rs5218</p> <p>rs5219</p> <p>rs2946788</p> <p>rs11227699</p> <p>rs7930460</p> <p>rs1800849</p> <p>rs1387153</p> <p>rs948028</p> <p>rs2270031</p> <p>rs2416791</p> <p>rs7961581</p> <p>rs2070586</p> <p>rs1503767</p> <p>rs2269793</p> <p>rs8050136</p> <p>rs818386</p> <p>rs2966849</p> <p>rs1879488</p> <p>rs757210</p> <p>rs2033111</p> <p>rs11652805</p> <p>rs10512572</p> <p>rs2125345</p> <p>rs12946618</p> <p>rs12946115</p> <p>rs12950541</p> <p>rs1885088</p> <p>rs3907047</p> <p>rs2071023</p> <p>rs2833479</p> <p>rs2833483</p> <p>rs2300386</p> <p>rs2835370</p> <p>rs1296819</p> <p>rs1892848</p> <p>rs4821004</p> <p> </p>
Dataset T2 Mapping from Super-Resolution-Reconstructed Clinical Fast Spin Echo Magnetic Resonance Acquisitions
<p>This dataset provides various acquisitions for T2 mapping of the MnCl2 array of the NIST phantom at 1.5T. Data were acquired on a MAGNETOM Sola (Siemens Healthcare, Erlangen, Germany), with an 18-channel body coil and a 32-channel spine coil (12 elements used). It gathers original acquisitions from Lajous H. et al. (2020) T2 Mapping from Super-Resolution-Reconstructed Clinical Fast Spin Echo Magnetic Resonance Acquisitions. In: Martel A.L. et al. (eds) Medical Image Computing and Computer Assisted Intervention – MICCAI 2020. MICCAI 2020. Lecture Notes in Computer Science, vol 12262. Springer, Cham. https://doi.org/10.1007/978-3-030-59713-9_12.</p> <p>The dataset is composed of DICOM images from:</p> <p>i) Gold-standard single-echo spin echo (SE) sequences acquired at variable TE;</p> <p>ii) Alternative reference multi-echo spin echo (MESE) acquisitions;</p> <p>iii) Half-Fourier Acquisition Single-shot Turbo spin Echo (HASTE) images at variable TE in three orthogonal orientations.</p> <p>The acquisition parameters are further detailed in the ReadMe.txt file provided along with the images.</p> <p>These acquisitions were repeated independently on three different days during the month of January 2020.</p> <p>These data are made publicly available as a support for further reproducibility studies as well as for the validation of new T2 relaxometry strategies.</p> <p>Works using any of these data should cite the following two references:</p> <p>- Lajous H. et al. (2020) T2 Mapping from Super-Resolution-Reconstructed Clinical Fast Spin Echo Magnetic Resonance Acquisitions. In: Martel A.L. et al. (eds) Medical Image Computing and Computer Assisted Intervention – MICCAI 2020. MICCAI 2020. Lecture Notes in Computer Science, vol 12262. Springer, Cham. https://doi.org/10.1007/978-3-030-59713-9_12</p> <p>- Lajous, Hélène, Ledoux, Jean-Baptiste, Hilbert, Tom, van Heeswijk, Ruud B., & Bach Cuadra, Meritxell. (2020). Dataset T2 Mapping from Super-Resolution-Reconstructed Clinical Fast Spin Echo Magnetic Resonance Acquisitions [Data set]. Zenodo. http://doi.org/10.5281/zenodo.3931812</p>
DATA SET: Performance Assessment of a Commercial Continuous-Wave Near-Infrared Spectroscopy Tissue Oximeter for Suitability for Use in an International, Multi-Center Clinical Trial
<p>This repository contains the data sets related to the publication:</p> <p>Cortese, L.; Zanoletti, M.; Karadeniz, U.; Pagliazzi, M.; Yaqub, M.A.; Busch, D.R.; Mesquida, J.; Durduran, T. Performance Assessment of a Commercial Continuous-Wave Near-Infrared Spectroscopy Tissue Oximeter for Suitability for Use in an International, Multi-Center Clinical Trial. <em>Sensors</em> <strong>2021</strong>, <em>21</em>, 6957. https://doi.org/10.3390/s21216957</p>
Epidemiological and clinical characteristics predictive of ICU mortality of traumatic brain injury patients treated at a trauma reference hospital – A cohort study - Dataset
<p><strong>Dataset of a cohort whose summary is described below.</strong></p> <p><strong>ABSTRACT</strong></p> <p><strong>Background</strong>: Traumatic brain injury (TBI) has substantial physical, psychological, social and economic impacts, with high rates of morbidity and mortality. Considering its high incidence, the aim of this study was to identify epidemiological and clinical characteristics that predict mortality in patients hospitalized for TBI in intensive care units (ICUs). <strong>Methods</strong>: A retrospective cohort study was carried out with patients over 18 years old with TBI admitted to an ICU of a Brazilian trauma referral hospital between January 2012 and August 2019. TBI was compared with other traumas in terms of clinical characteristics of ICU admission and outcome. Univariate and multivariate analyses were used to estimate the odds ratio for mortality. <strong>Results</strong>: Of the 4816 patients included, 1114 had TBI, with a predominance of males (85.1%). Compared with patients with other traumas, patients with TBI had a lower mean age (45.3 ± 19.1 versus 57.1 ± 24.1 years, p < 0.001), higher median APACHE II (19 versus 15, p <0.001) and SOFA (6 versus 3, p < 0.001) scores, lower median Glasgow Coma Scale (GCS) score (10 versus 15, p < 0.001), higher median length of stay (7 days versus 4 days, p < 0.001) and higher mortality (27.6% versus 13.3%, p < 0.001). In the multivariate analysis, the predictors of mortality were older age (OR: 1.008 [1.002-1.015], p = 0.016), higher APACHE II score (OR: 1.180 [1.155-1.204], p < 0.001), lower GCS score for the first 24 hours (OR: 0.730 [0.700-0.760], p < 0.001), and greater number of brain injuries and presence of associated chest trauma (OR: 1.727 [1.192-2.501], p < 0.001). <strong>Conclusion</strong>: Patients admitted to the ICU for TBI were younger and had worse prognostic scores, longer hospital stays and higher mortality than those admitted to the ICU for other traumas. The independent predictors of mortality were advanced age, APACHE II score, first 24-hour GCS score, number of brain injuries and chest trauma.</p>
Multi-head CRF classifier for biomedical multi-class Named Entity Recognition on Spanish clinical notes
<p>This contains the merged dataset as described in the work "<strong>Multi-head CRF classifier for biomedical multi-class Named Entity Recognition on Spanish clinical notes"</strong>.</p> <p>This dataset consists of 4 seperate datasets:</p> <ul> <li><a href="../records/8224056" target="_blank" rel="noopener">MedProcNer</a></li> <li><a href="../records/7614764" target="_blank" rel="noopener">DisTEMIST</a></li> <li><a href="../records/4270158" target="_blank" rel="noopener">PharmaCoNER</a></li> <li><a href="../records/10635215" target="_blank" rel="noopener">SympTEMIST</a></li> </ul> <p>The dataset contains two tasks:</p> <p><strong>Task 1:</strong> This task is related to multi-class Named Entity Recognition. This dataset contains 5 possible classes: SYMPTOM, PROCEDURE, DISEASE, CHEMICAL and PROTEIN.</p> <p><strong>Task 2:</strong> This task is related to Named Entity Linking, where each code corresponds to a code within the SNOMED-CT corpus. The exact corpus used can be obtained <a href="https://download.nlm.nih.gov/umls/kss/IHTSDO20190131/SnomedCT_SpanishRelease-es_PRODUCTION_20190430T120000Z.zip" target="_blank" rel="noopener">here</a>. Further for the MedProcNER, SympTEMIST and DisTEMIST datasets, a gazetteer is provided in the original datasets. </p> <p>For more information on the construction of the dataset, aswell as dataloaders, we refer you to our <a href="https://github.com/ieeta-pt/Multi-Head-CRF" target="_blank" rel="noopener">GitHub repository</a>.<br><br>Further this also contains the embeddings from the <a href="https://huggingface.co/cambridgeltl/SapBERT-UMLS-2020AB-all-lang-from-XLMR-large" target="_blank" rel="noopener">SapBERT</a> model.</p> <p><strong>Please, cite:</strong></p> <div> <div> <div> <div> <div> <div> <div> <div> <div> <div> <div> <div> <blockquote> <div>@article{jonker2024a, title = {Multi-head {{CRF}} classifier for biomedical multi-class named entity recognition on {{Spanish}} clinical notes}, author = {Jonker, Richard A. A. and Almeida, Tiago and Antunes, Rui and Almeida, Jo{\~a}o R. and Matos, S{\'e}rgio}, year = {2024}, journal = {Database}, publisher = {Oxford University Press} }</div> </blockquote> <div>Jonker, R. A. A., Almeida, T., Antunes, R., Almeida, J. R., & Matos, S. (2024). Multi-head CRF classifier for biomedical multi-class named entity recognition on Spanish clinical notes. (Submitted.) </div> <div> </div> <div> <p><strong>License</strong></p> <p>This work is licensed under a <a href="http://creativecommons.org/licenses/by/4.0/">Creative Commons Attribution 4.0 International License</a>.</p> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div>
Infection Inspection: Classifications and images of ciprofloxacin-treated Escherichia coli clinical isolates
<p>This dataset includes a .csv file with the image metadata and a folder of RGB images of <i>E. coli</i> grown from clinical isolates with varying concentrations of the antibiotic ciprofloxacin and varying minimum inhibitory concentrations. The <i>E. coli</i> cell membranes are stained with Nile Red and the DNA is stained with DAPI. The details of the image data collection are included in: https://doi.org/10.1038/s42003-023-05524-4. The classification data come from a Zooniverse citizen science project, Infection Inspection. (https://www.zooniverse.org/projects/conor-feehily/infection-inspection) Volunteers learned how to interpret ciprofloxacin response phenotypes as antibiotic-sensitive or antibiotic-resistant, and their classifications are included in the Metadata.csv file.</p><p>This dataset could be used for further analysis into the volunteer classifications, or the image data could be used for further image feature analysis of the ciprofloxacin response phenotypes.</p>
MiRoR11 - P2 - Annotated corpus for semantic similarity of clinical trial outcomes
<p>Outcome similarity corpus</p> <p>This dataset contains annotations of semantic similarity for pairs of primary and reported outcomes.<br> Tab-separated format is used. The files contain the following columns:<br> filename, sentence pair ID, sentence pair text, primary outcome, primary outcome start position, primary outcome end position, reported outcome, reported outcome start position, reported outcome end position, label</p> <p>The folder out_relations_split contains the dataset splits for 10-fold cross-validation.</p>
Post-trial access practice in Malaria, Tuberculosis, and NTDs Clinical Trial studies in Sub-Saharan African countries, quantitative study
<p>This is the data set used <span>to evaluate post trial access plan and implementation practice on TB, Malaria and NTD clinical trial studies conducted in the sub-Saharan African countries. </span></p>
Offering ART refill through community health workers versus clinic-based follow-up after home-based same-day ART initiation in rural Lesotho: The VIBRA cluster-randomised clinical trial
<p>These are pseudo-anonymised data from the VIBRA randomized trial: "Offering ART refill through community health workers versus clinic-based follow-up after home-based same-day ART initiation in rural Lesotho: The VIBRA cluster-randomised clinical trial". The data dictionary explains the data available in the dataset. Between August 2018 and May 2019, 257 eligible individuals from 117 consenting villages were enrolled from two districts of Lesotho, and followed up for a maximum of 15 months. The protocol was published, doi: 10.1186/s13063-019-3510-5</p>
TomoBreast randomized clinical trial's lung-heart outcomes and mortality through the 2020 COVID-19 pandemic: data and software
<p>Dataset and R script to reproduce the analyses of the manuscript:</p> <p>Vinh-Hung V, Gorobets O, Adriaenssens N, Van Parijs H, Storme G, Verellen D, Nguyen NP, Magne N, De Ridder M.</p> <p><strong>Lung-heart outcomes and mortality through the 2020 COVID-19 pandemic in a prospective cohort of breast cancer radiotherapy patients.</strong></p> <p>Cancers 2022; 14(24):6241. https:// doi.org/10.3390/cancers14246241</p> <p>https://www.mdpi.com/2072-6694/14/24/6241</p> <p>PubMed: PMID: 36551726</p> <p>PMCID: PMC9777311</p> <p>Info on the variables in file "aelq6_public.R"</p> <p>reproduced in "aelq_2_3_readme.txt":</p> <p>"aelq2_base2.txt" = baseline characteristics.</p> <p>"aelq3.txt" = longitudinal maesurements.</p> <p>Variables in "aelq2_base2.txt":</p> <p>"<strong>aelq2_base2.txt</strong>" = baseline characteristics. <br># Age at randomization, years. <br># RTdose: cf TomoBreast papers. <br># 51 Gy = hypofractionated, simultaneous integrated boost<br># 42 Gy = hypofractionated, no boost, mastectomy cases only<br># 50 Gy = conventional, no boost, mastectomy cases only<br># 66 Gy = conventional, sequential boost<br># Weight kg, Height cm, <br># Detection 1=found by screening (senology follow-up/controle)<br># 2=found by symptoms (pain, palpable)<br># 9=unknown<br># Smoker 0= Not smoker<br># 1= Smoker<br># 2=ex-smoker<br># Mastectomy (and other binary coded) 1= yes<br># chemosched 0=none<br># 1= planned after RT (sequential)<br># 2= prior to RT and is finished (sequential)<br># 3= chemo is on-going or is planned to start with RT (concomitant)<br># hormonetherapy 0=no<br># 1=tamoxifen (nolvadex)<br># 2=Femara (Letrozole)<br># 3=zoladex<br># 4=tamoxifen + zoladex<br># Laterality 1,=Right, 2=Left, 3=Bilateral<br># LengthFU: length of follow-up, days from randomization</p> <p>"<strong>aelq3.txt</strong>" = longitudinal maesurements.<br># "Nr" = Case ID<br># "Time" in days from origin (origin =date of randomization), <br># if negative =before randomization<br># "KPS" "Weight" <br># "Died" "LocalRec" "Metast" "NewPrim" = binary code, 0=no, 1=yes<br># "fAEBreast" "fAEHeart" "fAELung" "fAEOther" <br># fAE = freedom from breast, heart, lung, other adverse event score<br># "LVEF2" = ejection fraction, %<br># "MacIver" = estimated cardiac strain</p> <p># the following are pulmonary function tests, untransformed units<br># "FVC", "FEV1", "PEF", "VC", "TLC", "RV", "FRC", "Raw", "sRaw", "DLCO",<br># "VA", "PF"</p> <p># "fDY", "fFA", "fPA" = freedom from dyspnea, from fatigue, from pain<br># range 0 to 100 (best)<br># see papers:</p> <p># Van Parijs, H.; Vinh-Hung, V.; Fontaine, C.; Storme, G.; Verschraegen, C.;<br># Nguyen, D.M.; Adriaenssens, N.; Nguyen, N.P.; Gorobets, O.; De Ridder, M.<br># Cardiopulmonary-related patient-reported outcomes in a randomized clinical<br># trial of radiation therapy for breast cancer. BMC Cancer 2021, 21, 1177,<br># doi:10.1186/s12885-021-08916-z.</p> <p># preprint:<br># Van Parijs, H.; Cecilia-Joseph, E.; Gorobets, O.; Storme, G.; <br># Adriaenssens, N.; Heyndrickx, B.; Verschraegen, C.; Nguyen, N.P.;<br># De Ridder, M.; Vinh-Hung, V. Lung-heart toxicity in a randomized <br># clinical trial of hypofractionated image guided radiation therapy for<br># breast cancer. Preprints 2022, 202212, 0214.<br># https://doi.org/10.20944/preprints202212.0214.v1</p> <p># <br># "Year" = year of the observation<br># example: randomized 1/1/2011, measurement done 1/31/2011, time = 30 days,<br># Year =2011<br>#<br> </p>
Clinically approved small molecule antibiotics since 2010
<p>Properties of clinically approved small molecule antibiotics since 2010 are summarized.</p> <p>Properties include: Name Year approved Origin Mechanism of action Indication Administration Spectrum Protein binding Resistance Smiles Molweight cLogP cLogS H-Acceptors H-Donors Druglikeness DrugScore Total Molweight Monoisotopic Mass Total Surface Area Relative PSA Polar Surface Area LE from Molweight LLE from Molweight LELP from Molweight Shape Index Molecular Flexibility Molecular Complexity Structure of Smiles [idcode]</p> <p> </p> <p>Propeties in rows B to I were retrieved from the references cited in the dataset. <br> Properties in rows K - AC were calculated with DataWarrior. https://openmolecules.org/datawarrior/index.html</p>
CLUSTER anti-TNF clinical dataset
<p>This data dictionary describes the CLUSTER anti-TNF clinical dataset. It contains key variables of interest for measuring treatment response to tumour necrosis factor inhibitors (anti-TNF) in juvenile idiopathic arthritis (JIA) patients at baseline/timepoint 1 (start of anti-TNF treatment or up to 3 months before) and timepoint 2 (6 months after baseline, within a 3-12 month window). If a patient had multiple visits within a timepoint window, the one closest to baseline/6 months was selected. There are 2401 patients in this dataset.</p> <p>CLUSTER has brought together data from 4 UK observational JIA research cohort studies: the UK JIA Biologics Register, the Childhood Arthritis Prospective Study (CAPS) and the Childhood Arthritis Response to Medication Study (CHARMS). Clinical data from these studies was pooled to create the CLUSTER anti-TNF clinical dataset. More details of CLUSTER's clinical data harmonisation process are available here: <link></p> <p>We are open to collaborating and sharing data with researchers who have research questions that may be answered by our data. Access to CLUSTER data is regulated according to the conditions of patient consent, study ethics and the CLUSTER Consortium’s policies. Access is available to researchers via an application to the CLUSTER data access committee - more details are available on <a href="https://www.clusterconsortium.org.uk/">CLUSTER's website.</a></p>
CLUSTER MTX Clinical Dataset
<p>This data dictionary describes the CLUSTER MTX clinical dataset. It contains key variables of interest for measuring treatment response to methotrexate (MTX) in juvenile idiopathic arthritis (JIA) patients at baseline/timepoint 1 (start of MTX treatment or up to 3 months before) and timepoint 2 (6 months after baseline, within a 3-12 month window). If a patient had multiple visits within a timepoint window, the one closest to baseline/6 months was selected. There are 2899 patients in this dataset.</p> <p>CLUSTER has brought together data from 4 UK observational JIA research cohort studies: the UK JIA Biologics Register, the Childhood Arthritis Prospective Study (CAPS) and the Childhood Arthritis Response to Medication Study (CHARMS). Clinical data from these studies was pooled to create the CLUSTER MTX clinical dataset. More details of CLUSTER's clinical data harmonisation process are available here: <link></p> <p>We are open to collaborating and sharing data with researchers who have research questions that may be answered by our data. Access to CLUSTER data is regulated according to the conditions of patient consent, study ethics and the CLUSTER Consortium’s policies. Access is available to researchers via an application to the CLUSTER data access committee - more details are available on <a href="https://www.clusterconsortium.org.uk">CLUSTER's website.</a></p>
Dataset Treatment of early childhood caries with three different topical fluoride treatments: a randomised clinical trial
<p>These files contain the data and the research script about the effectiveness of the 38% silver diamine fluoride (SDF, SDI Riva Star) and Tiefenfluorid (TF, Humanchemie GmbH), using two different application protocols in children ≤71 months of age with early childhood caries, with a focus on patient-centred outcomes including major complications (pain, abscess, extraction) and minor complications (lesion progression).</p> <p>This work was funded by European Regional Development Fund Postdoc Latvia 1.1.1.2/VIAA/3/19/543, Contract No 9.-14.5/27. Uribe was supported by European Union’s Horizon 2020 grant agreement 857287 for the Baltic Biomaterials Centre of Excellence.</p>
Final Dataset for the DIssemination of REgistered COVID-19 Clinical Trials (DIRECCT) Study
<p>The DIRECCT study is a multi-phase examination of clinical trial results dissemination during the COVID-19 pandemic.</p> <p>Interim data for trials completed during the first six months of the pandemic (i.e., 1 January 2020 – 30 June 2020) was previously deposited at https://doi.org/10.5281/zenodo.4669936.<br> This data deposit comprises the results of searches for trials completed during the first 18-months of the pandemic (i.e., 1 January 2020 – 30 June 2021).<br> The data structure for the final phase of the project is not identical to the interim data as it was substantially more complex.<br> The data include datatables (CSVs) that can be treated as relational and joined on the `id` or `trn` columns. See datamodel.png for an overview of the data.</p> <p>Details on data sources and methods for the creation and analysis of this dataset are available in a detailed protocol (Version 3.1, 19 July 2023) : https://osf.io/w8t7r</p> <p>Note: This repository will be updated with additional information including a codebook and archives of raw data.</p> <p>Additional information on the project is available at the project's OSF page: https://doi.org/10.17605/osf.io/5f8j2.</p>
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.