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59 results for “clinical indicators”
Raw Data for the article: Current Perspectives on Adult Mesenchymal Stromal Cell-Derived Extracellular Vesicles: Biological Features and Clinical Indications
<p>Extracellular vesicles (EVs) constitute one of the main mechanisms by which cells communicate with the surrounding tissue or at distance. Vesicle secretion is featured by most cell types, and adult mesenchymal stromal cells (MSCs) of different tissue origins have shown the ability to produce them. In recent years, several reports disclosed the molecular composition and suggested clinical indications for EVs derived from adult MSCs. The parental cells were already known for their roles in different disease settings in regulating inflammation, immune modulation, or transdifferentiation to promote cell repopulation. Interestingly, most reports also suggested that part of the properties of parental cells were maintained by isolated EV populations. This review analyzes the recent development in the field of cell-free therapies, focusing on several adult tissues as a source of MSC-derived EVs and the available clinical data from in vivo models.</p>
Comprehensive clinical and genetic analyses of circulating bile acids and their associations with diabetes and its indices
<p>Files containing source data for "Comprehensive clinical and genetic analyses of circulating bile acids and their associations with diabetes and its indices," by Choucair et al., published in <em>Diabetes</em>.</p>
Clinically Indicated Magnetic Resonance Imaging in Patients With Cardiac Devices
ClinicalTrials.gov study NCT01130896. IPD Sharing: YES. Countries: 1. Publications: 4.
Precision Subtyping and Prognostic Study of Heart Failure Based on Multi-Omics Integration and Clinical Indicators: A Prospective Single-Center Cohort Study
ClinicalTrials.gov study NCT07355088. IPD Sharing: NO. Countries: 1. Publications: 9.
Data from: Genetic variants and clinical indicators used to build nomogram model
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Association between exposure to ecotoxicants and clinical and laboratory indices at clinical and preclinical stages of rheumatoid arthritis
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Clinical Indicators and Brain Image Data: a Study Based on Kailuan Cohort
ClinicalTrials.gov study NCT05453877. IPD Sharing: Not stated. Countries: 1. Publications: 5.
Exhaled Breath Particles as a Clinical Indicator for Lung Injury and Acute Respiratory Distress Syndrome (ARDS)
ClinicalTrials.gov study NCT04503057. IPD Sharing: NO. Countries: 1. Publications: 3.
Gonadal Tissue Freezing for Fertility Preservation in Individuals at Risk for Ovarian Dysfunction, Premature Ovarian Insufficiency and Clinically Indicated Gonadectomy
ClinicalTrials.gov study NCT04948658. IPD Sharing: UNDECIDED. Countries: 1. Publications: 3.
A Dose Escalation Phase I Study to Assess the Safety and Clinical Activity of Multiple Cancer Indications
ClinicalTrials.gov study NCT03018405. IPD Sharing: NO. Countries: 2. Publications: 2.
Effects of Behavioral Activation on Negative Emotions, Cancer-related Symptoms and Clinical Indicators in Cancer Patients
ClinicalTrials.gov study NCT06348940. IPD Sharing: NO. Countries: 1. Publications: 3.
Evaluation of a TNF-Alpha Modulator for Clinical and Molecular Indicators of Analgesic Effect
ClinicalTrials.gov study NCT00121563. IPD Sharing: Not stated. Countries: 1. Publications: 3.
Open Versus Closed Wedge Distal Femoral Varus Osteotomy for the Valgus Knee. Indications, Clinical and Radiological Outcome
ClinicalTrials.gov study NCT04382118. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Effectiveness of TAF in Reducing Clinical Events in CHB Patients Beyond Treatment Indications by Current Guidelines
ClinicalTrials.gov study NCT03753074. IPD Sharing: NO. Countries: 1. Publications: 14.
ANALYSIS OF CLINICAL AND LABORATORY VARIABLES WITH PREDICTION CAPABILITY FOR INDICATION OF INVASIVE MECHANICAL VENTILATION IN PATIENTS WITH COVID-19
ClinicalTrials.gov study NCT05663528. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Predictive value of clinical indices for intravenous immunoglobulin resistance and coronary artery lesion in Kawasaki disease
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Antibiotic tolerance indicative for persistence is pervasive among clinical Streptococcus pneumoniae isolates and shows strong condition dependence - dataset
<p>The dataset is linked to the article entitled 'Antibiotic tolerance indicative for persistence is pervasive among clinical <em>Streptococcus pneumoniae</em> isolates and shows strong condition dependence' with following abstract. </p> <p><em>Streptococcus pneumoniae</em> is an important human pathogen, being one of the most common causes of community-acquired pneumonia and otitis media. Antibiotic resistance in <em>S. pneumoniae</em> is an emerging problem as it depletes our arsenal of effective drugs. In addition, persistence also contributes to the antibiotic crisis in many other pathogens, yet, in <em>S. pneumonia</em>e little is known about antibiotic-tolerant persisters and robust experimental means are lacking. Persister cells are phenotypic variants that exist as a subpopulation within a clonal culture. Being tolerant to lethal antibiotics, they underly the chronic nature of a variety of infections and even help in acquiring genetic resistance. Here, we set out to identify and characterize persistence in <em>S. pneumoniae. </em>Specifically, we followed different strategies to overcome the self-limiting nature of<em> S. pneumoniae </em>as confounding factor in the prolonged monitoring of antibiotic survival needed to study persistence. In optimized conditions, we identified genuine persisters in various growth phases and for four relevant antibiotics through biphasic survival dynamics and heritability assays. Finally, we detected a high variety in antibiotic survival levels across a diverse collection of <em>S. pneumoniae</em> clinical isolates, which assumes that a high natural diversity in persistence is widely present in <em>S. pneumoniae</em>. Collectively, this proof-of-concept significantly progresses the understanding of the importance of antibiotic persistence in<em> S. pneumoniae</em> infections which will set stage for characterizing its relevance to clinical outcomes and advocates for increased attention to the phenotype in both fundamental and clinical research.</p>
Clinical Outcome of Pacemaker paTIents According to Pacing Modality and Primary INDications
ClinicalTrials.gov study NCT00976482. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Investigating Clinical Indicators of Spine Related Dysfunction Patterns. A Clinical Study on Neck Pain Patients.
ClinicalTrials.gov study NCT03147508. IPD Sharing: NO. Countries: 0. Publications: 2.
Verification of Correlation Between Genetic Testing of Nutritional Metabolism and Clinical Biochemical Indicators
ClinicalTrials.gov study NCT03651934. IPD Sharing: Not stated. Countries: 0. Publications: 1.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.