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23 results for “cobalamin”
Data From: Shedding light on cobalamin photodegradation in the ocean
<p>Cobalamin, vitamin B<sub>12</sub>, is an important micronutrient that has been investigated for decades in the marine context because it is required for phytoplankton growth. The biologically active forms (Me-B<sub>12</sub>, Ado-B<sub>12</sub>) and the synthetic form (CN-B<sub>12</sub>) quickly convert to OH-B<sub>12</sub> after light exposure in various aqueous solutions, but puzzlingly have been frequently reported to dominate dissolved cobalamin pools in the sunlit ocean. Here we document photodegradation timescales for these cobalamin forms in natural seawater using targeted mass spectrometry, providing quantitative evidence that OH-B<sub>12</sub> is expected to be the dominant dissolved form in irradiated seawater. Then, through high resolution mass spectrometry, we identify four photodegradation products of OH-B<sub>12</sub> which represent potential building blocks microbes could salvage and remodel to satisfy cellular cobalamin requirements. Taken together, these results clarify the impact of light on marine cobalamin dynamics, laying a foundation for a more quantitative understanding of the role of cobalamin in microbial communities and biogeochemical cycles.</p>
Fig. 1 in Genetics and biochemistry of cobalamin disorders
Fig. 1. Light trap.
Data From: Shedding light on cobalamin photodegradation in the ocean
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Data from: Seasonal patterns in B-vitamins and cobalamin co-limitation in the Northwest Atlantic
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Raw data for the paper "Cobalamin co-limits phytoplankton and bacterial biomass and activity in Eastern Mediterranean coastal waters"
<p>Raw data for the paper "Cobalamin co-limits phytoplankton and bacterial biomass and activity in Eastern Mediterranean coastal waters".</p> <p> </p>
EPI-743 in Cobalamin C Defect: Effects on Visual and Neurological Impairment
ClinicalTrials.gov study NCT01793090. IPD Sharing: Not stated. Countries: 1. Publications: 7.
Cobalamin Status in Young Children With Developmental Delay
ClinicalTrials.gov study NCT00710138. IPD Sharing: Not stated. Countries: 1. Publications: 7.
Cobalamin Supplementation During Infancy; Effect on B-vitamin Status, Growth and Psychomotor Development
ClinicalTrials.gov study NCT00479479. IPD Sharing: Not stated. Countries: 1. Publications: 5.
Cobalamin Status in Young Children With Gastrointestinal Symptoms or Feeding Problems
ClinicalTrials.gov study NCT00710359. IPD Sharing: Not stated. Countries: 1. Publications: 6.
Oral/Intramuscular B12 to Treat Cobalamin Deficiency
ClinicalTrials.gov study NCT01476007. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Efficacy and Safety Study of Oral Eligen® B12 in Subjects With Low Serum Cobalamin
ClinicalTrials.gov study NCT01312831. IPD Sharing: Not stated. Countries: 0. Publications: 1.
CblX disease is both an inborn error of cobalamin metabolism and a ribosomopathy
GEO Series GSE161763. Mus musculus. 9 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing.
Inherited disorders of cobalamin metabolism disrupt nucleocytoplasmic transport of mRNA through impaired methylation/phosphorylation of HuR
GEO Series GSE103417. Mus musculus. 24 samples. Type: Expression profiling by array.
Dioxin-elicited decrease in cobalamin redirects hepatic propionyl-CoA metabolism to the β–oxidation-like pathway resulting in acrylyl-CoA conjugate accumulation
GEO Series GSE203302. Mus musculus. 40 samples. Type: Expression profiling by high throughput sequencing.
Plasma Holotranscobalamin as Compared to Plasma Cobalamins for Assessment of Vitamin B12 Absorption
ClinicalTrials.gov study NCT00306358. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Interaction of Cobalamin Status With Nitrous Oxide in Relation to Postoperative Cognitive Changes in the Elderly
ClinicalTrials.gov study NCT00212147. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Cobalamin Supply and Metabolism in Healthy Children From Birth to the Age of 12 Months and in Their Mothers (Cbl_Neo)
ClinicalTrials.gov study NCT05315843. IPD Sharing: NO. Countries: 2. Publications: 0.
Cobalamin Absorption From Fortified Food
ClinicalTrials.gov study NCT01399164. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Cobalamin Deficiency - Diagnosis and Therapy
ClinicalTrials.gov study NCT04243707. IPD Sharing: NO. Countries: 1. Publications: 0.
THAP11F80L cobalamin disorder-associated mutation reveals normal and pathogenic THAP11 functions in gene expression and cell proliferation
GEO Series GSE138208. Homo sapiens. 10 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.