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580 results for “cocaine”
Patterns of reduced cortical thickness and striatum pathological morphology in cocaine addiction
<p>This dataset includes all the data and scripts needed to reproduce the analysis and results on the manuscript "Patterns of reduced cortical thickness and striatum pathological morphology in cocaine addiction" (<a href="https://www.biorxiv.org/content/early/2018/04/22/306068">link</a>). The brain data is not raw, as T1w were not defaced. We will do so in the near future for version 2.0. Instead we include only the "output/thickness" files used in the final analysis. For the use of raw T1w images, please contact the main author EAGV.</p> <p> </p> <p>Note: Paths will differ in the script.</p>
The Mexican dataset of an rTMS clinical trial on cocaine use disorder patients: SUDMEX TMS
<p>The SUDMEX_TMS dataset is the result of a longitudinal clinical trial of cocaine use disorder patients that were treated with rTMS at 5-Hz on the left dorsolateral prefrontal cortex (lDLPFC) for a 2 week double-blind acute phase and an open-label maintenance phase that included clinical, cognitive and MRI data acquisition. The design was a double-blind placebo-controlled randomized controlled trial with parallel groups (acute phase). The study was done at the National Institute of Psychiatry .</p> <p>Each patient had more than one clinical and MRI session or time point from baseline (T0), 2 weeks (T1), 3 months (T2), 6 months (T3) and some patients had 12 months (T4). The T14 time point was only for patients in the Sham group who decided to continue the clinical trial with open-label rTMS. The T14 refers to 2 weeks after T1 (4 weeks after T0).</p> <p>The MRI sequences were: 1) T1-weighted, 2) rsfMRI 10 min, 3) HARDI-DWI multishell (next release).</p> <p>The data set is curated and organized by test and item for each experimental phase and also has a dictionary to define the variables measured.</p> <p> </p> <p>If you require more information about data or scales, please contact us. </p> <p><em>LANIREM (</em><em>National MRI Laboratory)</em><em>, Institute of Neurobiology, </em></p> <p><em>Universidad Nacional Autónoma de México (UNAM), </em><em>Querétaro, México.</em></p> <p><strong>Diego Angeles Valdez, M. Sc. </strong></p> <ul> <li>diego.ang.val@gmail.com</li> <li>diego.ang.val@inb.unam.mx</li> </ul> <p><br> <strong>Eduardo A. Garza-Villarreal, M.D., Ph.D.</strong></p> <ul> <li>egarza@gmail.com</li> <li>egarza@comunidad.unam.mx</li> </ul>
SUDMEX_CONN: The Mexican dataset of cocaine use disorder patients.
<p>The SUDMEX_CONN is a Mexican open dataset of CUD patients and matched healthy controls that includes demographic, cognitive, clinical and magnetic resonance imaging (MRI) data.</p> <p>The study was done at the National Institute of Psychiatry in Mexico City</p> <p>The MRI sequences are available at https://openneuro.org/datasets/ds003346/versions/1.1.1</p> <p>If you require more information about data or scales, please contact us. </p> <p><em>LANIREM (</em><em>National MRI Laboratory)</em><em>, Institute of Neurobiology, </em></p> <p><em>Universidad Nacional Autónoma de México (UNAM), </em><em>Querétaro, México.</em></p> <p><strong>Diego Angeles Valdez, M. Sc. </strong></p> <ul> <li>diego.ang.val@gmail.com</li> <li>diego.ang.val@inb.unam.mx</li> </ul> <p><br> <strong>Eduardo A. Garza-Villarreal, M.D., Ph.D.</strong></p> <ul> <li>egarza@gmail.com</li> <li>egarza@comunidad.unam.mx</li> </ul> <p> </p> <p><strong>Updates</strong></p> <p>October 11-12, 2022</p> <p>The MINI PLUS was coded to reflect all the possible answers we had for questions about substance use as columns. For example, if the patient said to use more than 1 hallucinogen, we would mark the first one in Mini.L1.d1, then d2 is the second hallucinogen, then d3 is the third one.</p> <p>We updated the databases of the variables Addiction Severity Index (ASI), Barratt's Impulsivity Scale version 11 (BIS-11). and Clinical Global Impressions (CGI) Scale.</p> <p> </p> <pre> </pre>
Data from: Single-nucleus RNA-seq and ATAC-seq in outbred rats with divergent cocaine addiction behaviors reveal long-term changes in gene regulation and GABAergic inhibition in the amygdala
<p>This dataset accompanies our publication titled: "Single-nucleus RNA-seq and ATAC-seq in outbred rats with divergent cocaine addiction behaviors reveal long-term changes in gene regulation and GABAergic inhibition in the amygdala."</p> <p><strong>Files Included:</strong></p> <p><strong>1. geno.N26.vcf.gz</strong><br> - Description: Contains genotypes for 26 Heterogeneous Stock rats whose gene expression was predicted.</p> <p><strong>2. pred_expr.Brain.N26.tsv</strong><br> - Description: This tab-delimited table contains predicted relative gene expression in the brain for 26 Heterogeneous Stock rats. <br> - Details: Predictions were made for 8,997 genes from linear models based on cis-eQTLs from whole brain hemisphere tissue downloaded from the <a href="https://ratgtex.org/download/">RatGTEx Portal</a>. A gene is included in the table if it had at least one significant cis-eQTL, and if its predicted expression in these 26 animals had nonzero variance. The values in the table give the predicted log2(relative expression), where log2(2) = 1 is the baseline expression from the two haplotypes of the gene if it had only reference alleles at all its regulatory loci.<br> - Additional Info: Predictions were generated using <strong>gene_expr_pred.py</strong> available at https://github.com/PejLab/gene_expr_pred<br> An explanation of the prediction model is given in https://doi.org/10.1101/2022.01.28.478116</p> <p><strong>3. Behavioral data.xlsx</strong><br> - Description: Contains behavioral data for the Heterogeneous Stock (HS) rats.<br> - Organization: Each sheet in the file corresponds to data for a specific figure.</p> <p><strong>Additional Dataset Locations:</strong></p> <p>The primary datasets generated during this study can be found on the Gene Expression Omnibus under accession number <a href="https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE212417">GSE212417</a></p> <p><strong>Publicly Available Datasets Utilized:</strong></p> <p>- Rattus norvegicus Ensembl v98 reference genome and genome assembly: <a href="http://useast.ensembl.org/Rattus_norvegicus/Info/Index">Rnor_6.0 </a><br> - JASPAR2022 transcription factor binding profiles for vertebrates: <a href="https://jaspar.genereg.net/">JASPAR</a><br> - ENCODE Honeybadger 2 ChIP-seq: <a href="https://personal.broadinstitute.org/meuleman/reg2map/">Broad Institute</a><br> - Liu et al. 2019106 GWAS for tobacco and nicotine addiction summary statistics: <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6358542/">PubMed</a><br> - RatGTEx Portal tissue-specific cis-eQTLs: <a href="https://ratgtex.org/download/">RatGTEx Portal </a><br> - 1000 Genomes European reference panel: <a href="https://alkesgroup.broadinstitute.org/LDSCORE/">Alkes Group</a><br> - KEGG pathways: <a href="https://www.kegg.jp/kegg/rest/keggapi.html">KEGG API</a></p>
Cocaine Use Reduction and Health
ClinicalTrials.gov study NCT03224546. IPD Sharing: NO. Countries: 1. Publications: 3.
White matter deficits in cocaine use disorder V1.0
Open the record for dataset details and reuse information.
Phillips 2023 acute & repeated cocaine object
<p>Contains the integrated acute & repated cocaine R object published in Phillips et al 2023 <em>Molecular Cellular Neuorscience</em></p>
Theta-Burst Stimulation as a Treatment for Reducing Cocaine Use
ClinicalTrials.gov study NCT02927236. IPD Sharing: NO. Countries: 1. Publications: 3.
Study of the Effects of Risperdal Consta on Brain Reward Circuitry Function, Craving and Cocaine Use in Active Cocaine Dependence
ClinicalTrials.gov study NCT00385801. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Pharmacogenetics of Disulfiram for Cocaine
ClinicalTrials.gov study NCT00149630. IPD Sharing: NO. Countries: 1. Publications: 2.
Impact of Buspirone Maintenance on the Reinforcing Effects of Cocaine
ClinicalTrials.gov study NCT01639157. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Study of Adderall-XR for the Treatment of Adult Attention Deficit Hyperactivity Disorder and Cocaine Dependence
ClinicalTrials.gov study NCT00553319. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Improving Learning-based Treatment of Cocaine Dependence With Medication
ClinicalTrials.gov study NCT01526538. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Treatment With Lorcaserin for Cocaine Use: The TLC Study
ClinicalTrials.gov study NCT03192995. IPD Sharing: NO. Countries: 1. Publications: 73.
Quetiapine for the Reduction of Cocaine Use
ClinicalTrials.gov study NCT00631748. IPD Sharing: Not stated. Countries: 1. Publications: 1.
A Study of the Relationship Between Disulfiram and Cocaine Self-administration.
ClinicalTrials.gov study NCT00729300. IPD Sharing: NO. Countries: 1. Publications: 1.
Progesterone Treatment for Cocaine-dependent Women: A Pilot Study
ClinicalTrials.gov study NCT00632099. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Towards Detecting Cocaine Use Using Smartwatches in the NIDA Clinical Trials Network
ClinicalTrials.gov study NCT02915341. IPD Sharing: YES. Countries: 1. Publications: 2.
Bupropion-Enhanced Contingency Management (CM) for Cocaine Dependence
ClinicalTrials.gov study NCT02111798. IPD Sharing: UNDECIDED. Countries: 1. Publications: 1.
Effectiveness of Modafinil and D-amphetamine in Treating Cocaine Dependent Individuals
ClinicalTrials.gov study NCT00218062. IPD Sharing: Not stated. Countries: 1. Publications: 1.
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.