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zenodo44/100

Investigating the effect of cochlear synaptopathy on envelope following responses using a model of the auditory nerve

<p>Dataset&nbsp;containing the recorded and simulated data reported in the&nbsp;manuscript &quot;Investigating the effect of cochlear synaptopathy on envelope following responses using a model of the auditory nerve&quot; published in the&nbsp;Journal of the Association for Research in Otolaryngology, JARO (<a href="https://doi.org/10.1007/s10162-019-00721-7">https://doi.org/10.1007/s10162-019-00721-7</a>):</p> <ol> <li>RECORDED Envelope Following Responses (EFR) in normal-hearing (NH) threshold and hearing-impaired (HI) human listeners using deeply (m = 85%) and shallowly (m = 25%) modulated sinusoidally amplitude modulated (SAM) tones.</li> <li>SIMULATED EFRs using the auditory nerve (AN) model by&nbsp;Zilany et al. (2009, 2014).</li> </ol> <p>Files content and structure:</p> <p><strong>Recorded EFRs</strong></p> <p><strong>Fig. 2:</strong></p> <ul> <li><em>fig2__recorded_efr.csv</em>: &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp;<br> EFR recordings as a function of stimulus level (EFR magnitude-level&nbsp;functions)&nbsp;for the NH and HI listeners using two modulation depths.</li> </ul> <p>The file&nbsp;containing the recorded EFR data have the following columns:</p> <ul> <li><em>lvl</em>: &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; Stimulation level</li> <li><em>m85_ok: &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp;</em>EFR magnitude (dB re to 1&nbsp;&micro;V) using m =&nbsp;85%. Significant responses (F-test = 1)</li> <li><em>m85_ko: &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp;</em>EFR magnitude (dB re to 1&nbsp;&micro;V) using m =&nbsp;85%. Non-significant responses (F-test = 0)</li> <li><em>m85_bkg:&nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp;&nbsp;</em>Estimated background noise magnitude (dB re to 1&nbsp;&micro;V) for&nbsp;the recordings when m = 85%</li> <li><em>m25_ok: &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp;</em>EFR magnitude (dB re to 1&nbsp;&micro;V) using m = 25%. Significant responses (F-test = 1)</li> <li><em>m25_ko: &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp;</em>EFR magnitude (dB re to 1&nbsp;&micro;V) using m = 25%. Non-significant responses (F-test = 0)</li> <li><em>m25_bkg:&nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp;&nbsp;</em>Estimated background noise magnitude (dB re to 1&nbsp;&micro;V) for&nbsp;the recordings when m = 25%&nbsp;</li> <li><em>subj: &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp;</em>Listener id</li> <li>hearing: &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; Hearing group (nh | hi) of the listener</li> </ul> <p><strong>Simulated EFRs:</strong></p> <p><strong><em>Files with the simulation results summing across frequency and SR fiber type</em></strong></p> <p><strong>Fig. 4:</strong></p> <ul> <li><em>fig4a__simul_efr__nh_23ohc_13ihc__no_cs.csv</em>:&nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp;<br> Simulated EFR magnitude-level&nbsp;function for the NH threshold listeners (average) assuming 2/3 of OHC loss and 1/3 of IHC loss (Fig. 4a).</li> <li><em>fig4b__simul_efr__nh_slp_thres_all_ohc__no_cs.csv</em>: &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp;<br> Simulated EFR magnitude-level function for the NH threshold listeners (average) assuming sloping threshold at extended high frequencies (EHF) and all of OHC loss&nbsp;(Fig. 4b).</li> <li><em>fig4c__simul_efr__nh_slp_thres_all_ihc__no_cs.csv</em>:&nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp;<br> Simulated EFR magnitude-level function for the NH threshold listeners (average) assuming sloping threshold at extended high frequencies (EHF) and all of IHC loss&nbsp;(Fig. 4c).</li> <li><em>fig4d__simul_efr__hi_23ohc_13ihc__no_cs.csv</em>:&nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp;<br> Simulated EFR magnitude-level&nbsp;function for the HI listeners (average) assuming 2/3 of OHC loss and 1/3 of IHC loss (Fig. 4d).</li> <li><em>fig4e__simul_efr__hi_all_ohc__no_cs.csv</em>:&nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp;<br> Simulated EFR magnitude-level function for the HI threshold listeners (average) assuming&nbsp;all of OHC loss&nbsp;(Fig. 4e).</li> <li><em>fig4f__simul_efr__hi_all_ihc__no_cs.csv</em>:&nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp;<br> Simulated EFR magnitude-level function for the HI threshold listeners (average) assuming all of IHC loss&nbsp;(Fig. 4f).</li> <li><em>fig4g__simul_efr__hi_slp_thres_23ohc_13ihc__no_cs.csv</em>:&nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp;<br> Simulated EFR magnitude-level&nbsp;function for the HI listeners (average) assuming&nbsp;sloping threshold at EHF&nbsp;and 2/3 of OHC loss and 1/3 of IHC loss (Fig. 4d).</li> <li><em>fig4h__simul_efr__hi_slp_thres_all_ohc__no_cs.csv</em>:&nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp;<br> Simulated EFR magnitude-level function for the HI threshold listeners (average) assuming sloping threshold at EHF&nbsp;and all of OHC loss&nbsp;(Fig. 4e).</li> <li><em>fig4i__simul_efr__hi_slp_thres_all_ihc__no_cs.csv</em>:&nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp;<br> Simulated EFR magnitude-level function for the HI threshold listeners (average) assuming sloping threshold at EHF&nbsp;and and all of IHC loss&nbsp;(Fig. 4f).</li> </ul> <p>&nbsp;</p> <p><strong>Fig. 5:</strong></p> <ul> <li><em>fig5a__simul_efr__nh__cs_ms_ls_100p.csv</em>: &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp;<br> Simulated EFR magnitude-level function for the NH threshold listeners (average) assuming&nbsp;cochlear synaptopathy (CS) of a 100% of loss of only medium- and low-spontaneous rate (SR)&nbsp;AN fibers&nbsp;(Fig. 5a).</li> <li><em>fig5b__simul_efr__nh09_cs__approx</em>.<em>csv</em>: &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp;<br> Simulated EFR magnitude-level function to approximate the data for the NH threshold listener NH09 including CS (Fig. 5b).</li> <li><em>fig5c__simul_efr__hi04_cs__approx</em>.<em>csv</em>: &nbsp;<br> Simulated EFR magnitude-level function to approximate the data for the HI listener HI04&nbsp;including CS (Fig. 5c).</li> </ul> <p>&nbsp;</p> <p><strong>Fig. 6:</strong></p> <p>Files with the simulation results for the NH threshold listener&nbsp;in different characteristic frequency (CF) bands and SR fiber types</p> <ul> <li><em>fig6__simul_efr__nh_cf_band_analys__no_cs__m12.mat</em>: &nbsp; &nbsp; &nbsp; &nbsp; &nbsp;<br> Simulated EFR magnitude-level function for the NH using a SAM tone with m = 12%.</li> <li><em>fig6__simul_efr__nh_cf_band_analys__no_cs__m25.mat</em>: &nbsp; &nbsp; &nbsp; &nbsp; &nbsp;<br> Simulated EFR magnitude-level function for the NH using a SAM tone with m = 25%.</li> <li><em>fig6__simul_efr__nh_cf_band_analys__no_cs__m50.mat</em>: &nbsp; &nbsp; &nbsp; &nbsp; &nbsp;<br> Simulated EFR magnitude-level function for the NH using a SAM tone with m = 50%.</li> <li><em>fig6__simul_efr__nh_cf_band_analys__no_cs__m85.mat</em>: &nbsp; &nbsp; &nbsp; &nbsp; &nbsp;<br> Simulated EFR magnitude-level function for the NH using a SAM tone with m = 85%.</li> <li><em>fig6__simul_efr__nh_cf_band_analys__no_cs__m100.mat</em>: &nbsp; &nbsp; &nbsp; &nbsp;<br> Simulated EFR magnitude-level function for the NH using a SAM tone with m = 100%.</li> </ul> <p>&nbsp;</p> <p><strong>Fig. 7:</strong></p> <ul> <li><em>fig7a__simul_efr__bw_analys__32oct_[20, 40, 60, 80, 100]p.csv</em>: &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp;<br> Simulated EFR magnitude-level function for the NH threshold listeners assuming&nbsp;CS of a bandwidth (BW) of 3/2-octave for a loss of AN fibers ranging from 20% to&nbsp;100% (Fig. 7a).</li> <li><em>fig7b__simul_efr__bw_analys__1oct_[20, 40, 60, 80, 100]p.csv</em>: &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp;<br> Simulated EFR magnitude-level function for the NH threshold listeners assuming&nbsp;CS of a bandwidth (BW) of 1-octave for a loss of AN fibers ranging from 20% to&nbsp;100% (Fig. 7b).</li> <li><em>fig7c__simul_efr__bw_analys__13oct_[20, 40, 60, 80, 100]p.csv</em>:<br> Simulated EFR magnitude-level function for the NH threshold listeners assuming&nbsp;CS of a bandwidth (BW) of 1/3-octave for a loss of AN fibers ranging from 20% to&nbsp;100% (Fig. 7c).</li> </ul> <p>&nbsp;</p> <p>-----------------------------------------------------------------------------------------------------------------------------------------------------------------</p> <p>&nbsp;</p> <p>The structure of the .csv files that contain the EFR simulations is:</p> <ul> <li><em>lvl</em>: &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp;Stimulation level</li> <li><em>mgn_mxxx: &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp;</em>Simulated EFR magnitude (a.u. in dB) for each modulation depth (100%, 85%, 50%, 25% and 12%)</li> <li><em>bkg_mxxx: &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp;&nbsp;</em>Estimate of the background noise floor (a.u. in dB)&nbsp;for each modulation depth.&nbsp;</li> <li><em>ftest_mxxx: &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp;</em>Result of the F-test statistical test&nbsp;(0 or 1) for each modulation depth.</li> </ul> <p>&nbsp;</p> <p>The structure of the .mat&nbsp;files that contain the EFR simulations is:</p> <ul> <li><em>exper_type</em>:&nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp;Name of the simulated experiment</li> <li><em>species</em>:&nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp;Species used in the AN model (in this study is always 2: human)</li> <li><em>species_age</em>:&nbsp; &nbsp; &nbsp; &nbsp; &nbsp;(Not used in this work). Age of the animal when species is 4: mouse</li> <li>modulation<em>: &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp;</em>Modulation depth of the SAM tone used in the simulation <em>(100%, 85%, 50%, 25% or 12%)</em></li> <li><em>f_on: &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp;</em>Center frequency of the on-frequency band (<em>2000 Hz</em>)</li> <li><em>f_off_hf: &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp;&nbsp;</em>Center frequency of the first off-frequency band (<em>3000 Hz</em>)</li> <li><em>f_off_vhf: &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; </em>Center frequency of the second off-frequency band (<em>7000 Hz</em>)&nbsp;</li> <li><em>f_off_uvhf: &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; </em>Center frequency of the third&nbsp;off-frequency band (<em>12000 Hz</em>)</li> <li><em>lvl_vect: &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; </em>Stimulus level vector&nbsp;<em>(from 5 to 100 dB SPL, in steps of 5 dB)</em></li> <li><em>simul_efr &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp;&nbsp;</em>&nbsp;&nbsp;Structure with the simulated data <ul> <li>The data structure contains many fields which are&nbsp;matricies of size 3x20. The columns are the 20 stimulus levels defined in <em>lvl_vect</em>, and the first row is the simulated EFR, the second row is the estimates background noise floor in the simulation, and the third row is the output of the F-test statistics.</li> <li>The structure fields can be divided in&nbsp;4 groups: <ul> <li><em>ihc_</em> &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; Responses from the IHC (not shown in the paper)</li> <li><em>an_hs_</em> &nbsp; &nbsp; &nbsp;Responses from the High-SR fibers in the AN</li> <li><em>an_ms_</em> &nbsp; &nbsp; Responses from the Medium-SR fibers in the AN</li> <li><em>an_ls_</em> &nbsp; &nbsp; &nbsp; Responses from the Low-SR fibers in the AN</li> </ul> </li> <li>Each group has 5 responses corresponding to the on-frequency band (<em>_on</em>) and the three off-frequency bands (<em>_off_hf</em>, <em>_off_vhf</em>, <em>_off_uvhf</em>); and the sum across frequencies (<em>_across_f</em>)</li> </ul> </li> </ul>

opencc-by-4.0Aug 2017View details →
ClinicalTrials.gov24/100

Evaluation of the CochSyn Test Prototype to Measure Cochlear Synaptopathy

ClinicalTrials.gov study NCT06114680. IPD Sharing: NO. Countries: 1. Publications: 0.

closedIPD-NOFeb 2026View details →
ClinicalTrials.gov24/100

Fundamental and Clinical Study of Cochlear Synaptopathy

ClinicalTrials.gov study NCT06556160. IPD Sharing: Not stated. Countries: 1. Publications: 0.

restrictedIPD-UNDECIDEDFeb 2026View details →

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