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316 results for “cognitive dysfunction”
Cerebral microstructural alterations in Post-COVID-condition are related to cognitive impairment, olfactory dysfunction, and fatigue
<p>After contracting COVID-19, a substantial number of individuals develop a Post-COVID-Condition (PCC), marked by neurologic symptoms such as cognitive deficits, olfactory dysfunction, and fatigue, which can have detrimental socioeconomic consequences. Despite this, biomarkers and pathophysiological understandings of this condition remain limited. Employing magnetic resonance imaging, we conduct a comparative analysis of cerebral microstructure among patients with post-COVID condition, healthy controls, and individuals who contracted COVID-19 without long-term symptoms. This reveals widespread alterations in cerebral microstructure, attributed to a shift in volume from neuronal compartments to free fluid, associated with the severity of the initial infection. Correlating these alterations with cognition, olfaction, and fatigue unveils distinct affected networks, which are in a close anatomical-functional relationship with the respective symptoms. This plausibility of symptom-specific networks not only provides insights into the disease's pathophysiological foundations, which align well with an accelerated aging process but also underscores the significance of microstructure as an imaging biomarker.</p>
Cerebral microstructural alterations in Post-COVID-condition are related to cognitive impairment, olfactory dysfunction, and fatigue
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Deferoxamine Regulates Neuroinflammation and Iron Homeostasis in a Mouse Model of Postoperative Cognitive Dysfunction
<p>The raw data of the manuscript” Deferoxamine Regulates Neuroinflammation and Iron Homeostasis in a Mouse Model of Postoperative Cognitive Dysfunction”</p>
Outcome of severe COVID-19: spotlight on fatigue, fatiguability, multidomain complaints and pattern of cognitive deficits in a case series without prior brain dysfunction and without COVID-19-related stroke and/or cardiac arrest
<p>Outcome of severe COVID-19: spotlight on fatigue, fatiguability, multidomain complaints and pattern of cognitive deficits in a case series without prior brain dysfunction and without COVID-19-related stroke and/or cardiac arrest<br> Valérie Beaud1, Sonia Crottaz-Herbette1, Vincent Dunet2, Jean-François Knebel1, Pierre-Alexandre Bart3, Stephanie Clarke1<br> 1 Service of Neuropsychology and Neurorehabilitation, Lausanne University Hospital and University of Lausanne, 1011 Lausanne, Switzerland<br> 2 Service of Diagnostic and Interventional Radiology, Lausanne University Hospital and University of Lausanne, 1011 Lausanne, Switzerland<br> 3 Service of Internal Medicine, Lausanne University Hospital and University of Lausanne, 1011 Lausanne, Switzerland<br> ABSTRACT<br> Background: Cognitive deficits were often reported during the acute and post-acute stages of severe COVID-19 and were often, but not always, associated with signs of brain damage. Population-wide surveys highlighted the need for investigations into the nature, the severity and the evolution of cognitive, behavioural and psychiatric deficits.<br> Case presentation: We report the outcome at 12 months after severe COVID-19 involving intensive care unit stay and mechanical ventilation in six patients. None of the patients had history of prior brain dysfunction and none sustained stroke and/or cardiac arrest during COVID-19. A pervading mental and physical fatigue was consistently reported as well as numerous multidomain complaints, which affect to some extend everyday life, and for some of the patients a mental fatiguability, a certain degree of neurobehavioural (apathy) and/or psychiatric (anxiety) dysfunction. Standardized neuropsychological tests revealed for 4 of the 6 patients the occurrence relatively isolated of cognitive dysfunction or performance at the lower limit of the norm in some, but not all attentional, executive and/or working memory tests. Somatic scales highlighted the presence of dyspnoea, muscle weakness, olfactory disorder and/or minor sleep problems in some but not all patients.<br> Conclusion: Fatigue, fatiguability, multidomain complaints, which affect to some extend everyday life, cognitive dysfunction or performance at the lower limit of the norm and a certain degree of neurobehavioural and/or psychiatric and/or somatic dysfunction can occur in the aftermath of severe COVID-19 even in the absence of neurological antecedents or of COVID-19-related stroke and/or cardiac arrest.</p>
Validation of the Freund Clock Drawing Test to Screen for Cognitive Dysfunction in Cancer Patients
ClinicalTrials.gov study NCT01749995. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Cognitive Dysfunction in Chronic and Persistent Immune Thrombocytopenia
ClinicalTrials.gov study NCT06817395. IPD Sharing: YES. Countries: 1. Publications: 3.
Curcumin as a Novel Treatment to Improve Cognitive Dysfunction in Schizophrenia
ClinicalTrials.gov study NCT02104752. IPD Sharing: Not stated. Countries: 1. Publications: 5.
Modulating ApoE Signalling to Reduce Brain Inflammation, deLirium and postopErative Cognitive Dysfunction
ClinicalTrials.gov study NCT03802396. IPD Sharing: NO. Countries: 1. Publications: 0.
High-Intensity Exercise to Combat Vascular and Cognitive Dysfunction in Adults With HIV
ClinicalTrials.gov study NCT05965518. IPD Sharing: YES. Countries: 1. Publications: 1.
Cannabidiol Treatment of Cognitive Dysfunction in Schizophrenia
ClinicalTrials.gov study NCT00588731. IPD Sharing: Not stated. Countries: 1. Publications: 1.
CPAP to Treat Cognitive Dysfunction in MS
ClinicalTrials.gov study NCT02544373. IPD Sharing: Not stated. Countries: 1. Publications: 26.
Efficacy of Lu AA21004 on Cognitive Dysfunction in Major Depressive Disorder
ClinicalTrials.gov study NCT01564862. IPD Sharing: Not stated. Countries: 7. Publications: 6.
Treximet for Prevention of Post Traumatic Headache Associated With Cognitive Dysfunction
ClinicalTrials.gov study NCT01053507. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Impact of Anodal tDCS and Virtual Reality on Cognitive Dysfunction in Patients With Multiple Sclerosis
ClinicalTrials.gov study NCT07114809. IPD Sharing: NO. Countries: 1. Publications: 21.
Naratriptan for the Treatment of Post Traumatic Headache Associated With Cognitive Dysfunction
ClinicalTrials.gov study NCT00487578. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Postoperative Cognitive Dysfunction in Transsphenoidal Pituitary Surgeries
ClinicalTrials.gov study NCT06793150. IPD Sharing: NO. Countries: 1. Publications: 3.
Cohort Study to Investigate the Association Between Changes in Brain Volume and Postoperative Cognitive Dysfunction
ClinicalTrials.gov study NCT02045004. IPD Sharing: UNDECIDED. Countries: 1. Publications: 31.
Correlation of Preoperative Anxiety With Early Postoperative Cognitive Dysfunction in Breast Cancer Patients
ClinicalTrials.gov study NCT04701801. IPD Sharing: UNDECIDED. Countries: 1. Publications: 5.
The Impact of Perioperative Transfusion on Postoperative Cognitive Dysfunction
ClinicalTrials.gov study NCT04155489. IPD Sharing: Not stated. Countries: 1. Publications: 6.
Postoperative Cognitive Dysfunction in Elderly Urologic Oncology Patients (POCD)
ClinicalTrials.gov study NCT04837391. IPD Sharing: NO. Countries: 1. Publications: 6.
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.