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ShareScore release 0.9.0
Dataset results
12 results for “collateral sensitivity”
Data from: Collateral sensitivity interactions between antibiotics depend on local abiotic conditions
<p>Mutations conferring resistance to one antibiotic can increase (cross resistance) or decrease (collateral sensitivity) resistance to others. Antibiotic combinations displaying collateral sensitivity could be used in treatments that slow resistance evolution. However, lab-to-clinic translation requires understanding whether collateral effects are robust across different environmental conditions. Here, we isolated and characterized resistant mutants of <i>Escherichia coli</i> using five antibiotics, before measuring collateral effects on resistance to other paired antibiotics. During both isolation and phenotyping, we varied conditions in ways relevant in nature (pH, temperature, bile). This revealed local abiotic conditions modified expression of resistance against both the antibiotic used during isolation and other antibiotics. Consequently, local conditions influenced collateral sensitivity in two ways: by favouring different sets of mutants (with different collateral sensitivities), and by modifying expression of collateral effects for individual mutants. These results place collateral sensitivity in the context of environmental variation, with important implications for translation to real-world applications.</p>
Data from: Collateral sensitivity interactions between antibiotics depend on local abiotic conditions
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Evolution under vancomycin selection drives divergent collateral sensitivity patterns in <em>Staphylococcus aureus</em>
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Data from: Macrophage adaptation leads to parallel evolution of genetically diverse Escherichia coli small-colony variants with increased fitness in vivo and antibiotic collateral sensitivity
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Data from: Patterns of cross-resistance and collateral sensitivity between clinical antibiotics and natural antimicrobials
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Acquired resistance to PRMT5 inhibition and the consequent collateral sensitivity to paclitaxel are both Stmn2 dependent
GEO Series GSE157715. Mus musculus. 15 samples. Type: Expression profiling by high throughput sequencing.
Prediction of Cross-resistance and Collateral Sensitivity by Gene Expression profiles and Genomic Mutations.
GEO Series GSE89746. Escherichia coli; Escherichia coli str. K-12 substr. MDS42. 124 samples. Type: Expression profiling by array.
Collateral sensitivity of antibiotic resistant bacteria to antimicrobial peptides
GEO Series GSE96706. Escherichia coli. 84 samples. Type: Expression profiling by high throughput sequencing.
Exploiting collateral sensitivity in the evolution of resistance to tyrosine kinase inhibitors in soft tissue sarcomas.
GEO Series GSE298261. Homo sapiens. 20 samples. Type: Expression profiling by high throughput sequencing.
Exploiting Temporal Collateral Sensitivity in Tumor Clonal Evolution
GEO Series GSE72910. Mus musculus. 10 samples. Type: Expression profiling by high throughput sequencing.
Collateral Responses to Classical Cytotoxic Chemotherapies are Heterogeneous and Sensitivities are Sparse
GEO Series GSE166425. Mus musculus. 30 samples. Type: Expression profiling by high throughput sequencing.
Phenotypic convergent evolution towards fosfomycin collateral sensitivity of Pseudomonas aeruginosa antibiotic resistant mutants
GEO Series GSE153006. Pseudomonas aeruginosa. 5 samples. Type: Expression profiling by high throughput sequencing.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.