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Dataset results
144 results for “collaterals”
Dataset from "In silico assessment of collateral eddy current heating in biocompatible implants subjected to magnetic hyperthermia treatments"
<p>This dataset from the publication entitled "Dataset from "In silico assessment of collateral eddy current heating in biocompatible implants subjected to magnetic hyperthermia treatments" contains simulated data of magnetic hyperthermia treatments for three different indications: colorectal cancer, prostate cancer and head & neck cancer. Since the aim of the study is to evaluate the risk of thermal damage caused by the collateral heating of two common types of passive prostheses (hip and dental implants), eddy currents induced in these implants upon interacting with the externally applied ac field during treatment have been computed for all the evaluated regions. Two different alloys for the implants have been considered for each case as well: Ti6Al4V and CoCrMo. At the same time, besides temperature, the specific abosorption rate (SAR) have been also computed to work out the energy deposition in tissues.</p> <p>Calculations have been carried out using a het exchange model with and without thermoregulation.</p> <p>log-log SAR vs T plots have been obtained and proposed as a quick means to pre-check treatment feasibility in each patient. These graphs are thought to be included in treatment planning prior to the clinical procedure.</p> <p>Other parameters taken into account have been the treatment time (5 and 30 minutes), and the maximum tolerable temperature threshold (1 or 5 ºC, as indicated by the ICNIRP commission), all for three main types of tissues, namely fat, bone and muscle. Each tissue have been simulated using three different field intensities (5, 10 and 15 mT).</p> <p>The field frequency has been 300 kHz in all cases.</p> <p>The files "Dataset_description.doc" and "file_scheme.txt" contain the structure and description of the files that make up the dataset.</p> <p>UPDATES FROM PREVIOUS VERSIONS: simulations of the dental implant without thermoregulation have been added.</p>
Vesicular release probability sets the strength of individual Schaffer collateral synapses
<p>This repository contains the data used to generate the figures of the manuscript entitled 'Vesicular release probability sets the strength of individual Schaffer collateral synapses' and all the data used for the quantal analysis.</p>
Data for "Unravelling the collateral damage of antibiotics on gut bacteria"
<p>This dataset encompasses all data needed to reproduce the analyses presented in the paper "Unravelling the collateral damage of antibiotics on gut bacteria", available here: https://doi.org/10.1038/s41586-021-03986-2</p> <p>You can also check the GitLab repository: https://git.embl.de/maier/abxbug/</p>
Data from: Collateral sensitivity interactions between antibiotics depend on local abiotic conditions
<p>Mutations conferring resistance to one antibiotic can increase (cross resistance) or decrease (collateral sensitivity) resistance to others. Antibiotic combinations displaying collateral sensitivity could be used in treatments that slow resistance evolution. However, lab-to-clinic translation requires understanding whether collateral effects are robust across different environmental conditions. Here, we isolated and characterized resistant mutants of <i>Escherichia coli</i> using five antibiotics, before measuring collateral effects on resistance to other paired antibiotics. During both isolation and phenotyping, we varied conditions in ways relevant in nature (pH, temperature, bile). This revealed local abiotic conditions modified expression of resistance against both the antibiotic used during isolation and other antibiotics. Consequently, local conditions influenced collateral sensitivity in two ways: by favouring different sets of mutants (with different collateral sensitivities), and by modifying expression of collateral effects for individual mutants. These results place collateral sensitivity in the context of environmental variation, with important implications for translation to real-world applications.</p>
Amplicon structure creates collateral therapeutic vulnerability in cancer
<p>Raw RNA sequencing data expressed in KELLY cells with vs. without ectopic DDX1 expression</p> <p>AH_YB_021 DDX1, AH_YB_023 DDX1, AH_YB_025 DDX1, : DDX1 -</p> <p>AH_YB_022 DDX1, AH_YB_024 DDX1, AH_YB_026 DDX1, : DDX1 +</p>
Allele-specific collateral and fitness effects determine the dynamics of fluoroquinolone-resistance evolution
<p>Collateral sensitivity (CS), which arises when resistance to one antibiotic increases sensitivity towards other antibiotics, offers novel treatment opportunities to constrain or reverse the evolution of antibiotic resistance. The applicability of CS-informed treatments remains uncertain, in part because we lack an understanding of the generality of CS effects for different resistance mutations, singly or in combination. Here we address this issue in the Gram-positive pathogen <em>Streptococcus</em> <em>pneumoniae</em> by measuring collateral and fitness effects of clinically relevant <em>gyrA</em> and <em>parC</em> alleles, and their combinations, that confer resistance to fluoroquinolones. We integrated these results in a mathematical model which allowed us to evaluate how different <em>in</em> <em>silico</em> combination treatments impact the dynamics of resistance evolution. We identified common and conserved CS effects of different <em>gyrA</em> and <em>parC</em> alleles; however, the spectrum of collateral effects was unique for each allele or allelic pair. This indicated that allelic identity can impact the evolutionary dynamics of resistance evolution during monotreatment and combination treatment. Our model simulations, which included the experimentally derived antibiotic susceptibilities and fitness effects, and antibiotic-specific pharmacodynamics, revealed that both collateral and fitness effects impact the population dynamics of resistance evolution. Overall, we provide evidence that allelic identity and interactions can have a pronounced impact on collateral effects of different antibiotics and suggest that these need to be considered in models examining CS-based therapies.</p>
Head Down Tilt 15° to Increase Collateral Flow in Acute Ischemic Stroke
ClinicalTrials.gov study NCT06297863. IPD Sharing: YES. Countries: 1. Publications: 5.
Data from: Collateral sensitivity interactions between antibiotics depend on local abiotic conditions
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Allele-specific collateral and fitness effects determine the dynamics of fluoroquinolone-resistance evolution
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Evolution under vancomycin selection drives divergent collateral sensitivity patterns in <em>Staphylococcus aureus</em>
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"An Empirical Study of i18n Collateral Changes and Bugs in GUIs of Android apps" Complementary Material
<p>Study results for the paper: "An Empirical Study of i18n Collateral Changes and Bugs in GUIs of Android apps"</p>
Collateral benefits of targeted supplementary feeding on demography and growth rate of a threatened population
<p>1. Effective evidence-based conservation requires full quantification of the impacts of targeted management interventions on focal populations. Such impacts may extend beyond target individuals to also affect demographic rates of non-target conspecifics (e.g. different age classes). However, such collateral (i.e. unplanned) impacts are rarely evaluated, despite their potential to substantially alter conservation outcomes. Subsequent management decisions may then be poorly informed or erroneous.</p> <p>2. We used 15 years of individual-based demographic data in a "before-after control-impact" (BACI) analysis to quantify collateral demographic impacts of a targeted multi-year supplementary feeding programme designed to increase sub-adult survival and hence viability of a small, threatened red-billed chough (<i>Pyrrhocorax pyrrhocorax</i>) population. Specifically, we assessed whether the intervention also affected adult survival and reproductive success, and whether such collateral effects were themselves sufficient to stabilise population size and hence achieve short-term conservation aims.</p> <p>3. The probabilities of adult survival and successful reproduction increased substantially between the "before-feeding" and "during-feeding" periods in those choughs associated with supplementary feeding, but not otherwise. Overall breeding success (i.e. number of chicks fledged per occupied territory) also tended to increase, even though brood sizes did not increase. These relationships, which were detectible only through BACI analyses, suggest that supplementary feeding targeted at sub-adults had unplanned positive impacts on adult demographic rates.</p> <p>4. Deterministic matrix models designed to project population growth demonstrate that these estimated collateral effects were sufficient to make a substantial contribution to increasing population growth rate and achieving short-term population stability.</p> <p>5. Synthesis and applications. Our results indicate substantial positive collateral impacts of a targeted supplementary feeding intervention on population viability, despite no <i>a priori</i> expectation that the non-target adults were food-limited. This case-study illustrates how thorough assessment of collateral impacts of targeted interventions can affect assessment of short-term efficacy and reveal new opportunities for future interventions, thereby informing subsequent management decisions.</p>
Uncertainty quantification in cerebral circulation simulations focusing on the collateral flow: Surrogate model approach with machine learning
<p>Data and code underlying the findings reported in the paper titled "Uncertainty quantification in cerebral circulation simulations focusing on the collateral flow: Surrogate model approach with machine learning."</p>
Source data sets_Figure 1, 2, 6_Salmonella cancer therapy metabolically disrupts tumours at the collateral cost of T cell immunity
<p>Flow cytometry data files associated with Copland <em>et al., </em><strong><em><span>Salmonella </span></em></strong><strong><span>cancer therapy metabolically disrupts tumours at the collateral cost of T cell immunity.</span></strong></p> <p><span>Data associated to Figures 1, 2 and 6. <br></span></p>
Data from: Collateral damage or a shadow of safety? The effects of signaling heterospecific neighbors on the risks of parasitism and predation
Although males often display from mixed-species aggregations, the influence of nearby heterospecifics on risks associated with sexual signaling has not been previously examined. We tested whether predation and parasitism risks depend on proximity to heterospecific signalers. Using field playback experiments with calls of two species that often display from the same ponds, túngara frogs and hourglass treefrogs, we tested two hypotheses: (1) Calling near heterospecific signalers attractive to eavesdroppers results in increased attention from predatory bats and parasitic midges (Collateral Damage hypothesis); or (2) Calling near heterospecific signalers reduces an individual's predation and parasitism risks, as eavesdroppers are drawn to the heterospecifics (Shadow of Safety hypothesis). Bat visitation was not affected by calling neighbors. The number of frog-biting midges attracted to hourglass treefrog calls, however, rose threefold when played near túngara calls, supporting the collateral damage hypothesis. We thus show that proximity to heterospecific signalers can drastically alter both the absolute risks of signaling and the relative strengths of pressures from predation and parasitism. Through these mechanisms, interactions between heterospecific guild members are likely to influence the evolution of signaling strategies and the distribution of species at both local and larger scales.
Replication package for: Credit Access, Selection, and Incentives in a Market for Asset Collateralized Loans: Evidence from Kenya
<p>Paper: Credit Access, Selection, and Incentives in a Market for Asset Collateralized Loans: Evidence from Kenya, by William Jack, Michael Kremer, Joost de Laat and Tavneet Suri, Forthcoming, the Review of Economic Studies.</p> <p>The replication package includes the data and do files for the experiment reported on in the paper. </p>
The Correlation Between CITED2 and Collateral Circulation in Acute Ischemic Stroke
ClinicalTrials.gov study NCT05345366. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Study of Collateral Circulation in Patients With Symptomatic Intracranial Anterior Circulation Occlusion
ClinicalTrials.gov study NCT04091412. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Prevalence of Extracardiac Coronary Collateral Supply Via the Internal Mammary Arteries
ClinicalTrials.gov study NCT01676207. IPD Sharing: Not stated. Countries: 1. Publications: 1.
COronary CoLLateralization in Type 2 diabEtic Patients With Chronic Total Occlusion
ClinicalTrials.gov study NCT06054126. IPD Sharing: NO. Countries: 1. Publications: 2.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.