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Dataset results
354 results for “colorectal cancer screening”
CRISPR/dCas9-mediated DNA demethylation screen identifies driver epigenetic determinants of colorectal cancer (Processed data)
<p><strong>Background:</strong> Promoter hypermethylation of tumour suppressor genes is frequently observed during the malignant transformation of colorectal cancer (CRC). However, whether this epigenetic mechanism is an actual driver of cancer or is a mere consequence of the carcinogenic process remains to be elucidated.</p> <p><strong>Results: </strong>In this work we performed an integrative multi -omic approach to identify gene candidates with strong correlations between DNA methylation and gene expression in human CRC samples and a set of 8 colon cancer cell lines. As a proof of concept, we combined recent CRISPR-Cas9 epigenome editing tools (dCas9-TET1, dCas9-TET-IM) with a custom arrayed gRNA library to modulate the DNA methylation status of 56 promoters previously linked with strong epigenetic repression in CRC, and we monitored the potential functional consequences of such DNA methylation loss by means of a high-content cell proliferation screen. Overall, the epigenetic modulation of most of these DNA methylated regions had a mild impact in the reactivation of gene expression and in the viability of cancer cells. Interestingly, we found that epigenetic reactivation of RSPO2 in the tumour context was associated with a significant impairment in cell proliferation in p53-/- cancer cell lines and further validation with human samples demonstrated that the epigenetic silencing of RSPO2 is a mid-late event in the adenoma to carcinoma sequence.</p> <p><strong>Conclusions: </strong>These results highlight the potential role of DNA methylation as a driver mechanism of CRC and open up the venue for the identification of novel therapeutic windows based on the epigenetic reactivation of certain tumour suppressor genes.</p>
An Evaluation of a Multi-target Stool DNA (Mt-sDNA) Test, Cologuard, for CRC Screening in Individuals Aged 45-49 and at Average Risk for Development of Colorectal Cancer: Act Now
ClinicalTrials.gov study NCT03728348. IPD Sharing: YES. Countries: 1. Publications: 1.
Helping Patients and Providers Make Better Decisions About Colorectal Cancer Screening
ClinicalTrials.gov study NCT04683731. IPD Sharing: YES. Countries: 1. Publications: 1.
Paired Promotion of Colorectal Cancer and Social Determinants of Health Screening
ClinicalTrials.gov study NCT04585919. IPD Sharing: YES. Countries: 1. Publications: 2.
Search Strategies for the Cost Effectiveness of Colorectal Cancer Screening
<p><span>The dataset includes the complete, reproducible search strategies for all bibliographic databases searched during this project. The search strategies were designed to answer the following research question:</span></p> <p><span>For the Irish population at average risk of colorectal cancer, is biennial FIT-based colorectal cancer screening at a FIT threshold of 45 ug/g, in persons aged from age 50 to 74 years, cost effective compared to screening in persons aged 55 to 74 years</span></p>
Promoting Veteran-Centered Colorectal Cancer Screening
ClinicalTrials.gov study NCT02027545. IPD Sharing: NO. Countries: 1. Publications: 5.
Quality Improvement of Patient-Provider Communication For Colorectal Cancer Screening
ClinicalTrials.gov study NCT00324753. IPD Sharing: NO. Countries: 1. Publications: 1.
Social Media for Colorectal Cancer Screening
ClinicalTrials.gov study NCT04296630. IPD Sharing: NO. Countries: 1. Publications: 0.
Screening With a DNA Blood Test to Address Colorectal Cancer Inequities
ClinicalTrials.gov study NCT06929481. IPD Sharing: NO. Countries: 1. Publications: 19.
Engaging Black Men in Colorectal Cancer Screening
ClinicalTrials.gov study NCT05980182. IPD Sharing: YES. Countries: 1. Publications: 1.
Low-Literacy Physician-Patient Intervention Promoting Colorectal Cancer Screening
ClinicalTrials.gov study NCT01103479. IPD Sharing: Not stated. Countries: 1. Publications: 3.
Implementing a Multilevel Intervention to Accelerate Colorectal Cancer Screening and Follow-up
ClinicalTrials.gov study NCT04514341. IPD Sharing: NO. Countries: 1. Publications: 1.
Effectiveness of Direct-to-Patient Outreach on Colorectal Cancer Screening Within a Low Income and Diverse Population
ClinicalTrials.gov study NCT01385579. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Clinical Validation of An Optimized Multi-Target Stool DNA (Mt-sDNA 2.0) Test, for Colorectal Cancer Screening "BLUE-C"
ClinicalTrials.gov study NCT04144738. IPD Sharing: YES. Countries: 1. Publications: 3.
Study of Colorectal Cancer Screening Options
ClinicalTrials.gov study NCT05987709. IPD Sharing: NO. Countries: 1. Publications: 1.
Screening More Patients for Colorectal Cancer Through Adapting and Refining Targeted Evidence-Based Interventions in Rural Settings, SMARTER CRC
ClinicalTrials.gov study NCT04890054. IPD Sharing: YES. Countries: 1. Publications: 3.
Screening for Colorectal Cancer in Older Patients (PLCO Screening Trial)
ClinicalTrials.gov study NCT01696981. IPD Sharing: Not stated. Countries: 1. Publications: 6.
Shared Decision-Making for Colorectal Cancer Screening
ClinicalTrials.gov study NCT00251862. IPD Sharing: Not stated. Countries: 1. Publications: 5.
Increasing Colorectal Cancer (CRC) Screening Among Hispanic Primary Care Patients
ClinicalTrials.gov study NCT02272244. IPD Sharing: NO. Countries: 1. Publications: 1.
Audio and Video Brochures for Increasing Colorectal Cancer Screening Among Adults Living in Appalachia
ClinicalTrials.gov study NCT05810714. IPD Sharing: NO. Countries: 1. Publications: 1.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.