Find research datasets worth reusing
Search datasets from major research repositories and use ShareScore to quickly assess how well each record supports discovery, access, and reuse.
3,262
datasets available to search
ShareScore release 0.7.1
Dataset results
3,262 results for “combination therapy”
Plasmodium falciparum infection in febrile Congolese children: prevalence of clinical malaria ten years after introduction of Artemisinin-combination therapies
<p>dataset used in the paper.</p>
A comparative study of the effectivity of MSC-based, NP-based and combined therapies in an experimental model of NaIO3-induced retinal degeneration
<div><strong>Background</strong></div> <div>Mesenchymal stem cells (MSCs) are currently tested as one of the promising options for the therapy of retinal diseases, due to their immunomodulatory and neuroprotective abilities. However, there are several limitations associated with this type of treatment. Therefore, combinations of MSCs with other therapeutic agents are being considered. One of such approaches is represented by the application of MSCs with nanoparticles (NPs), which are widely used in medicine for their antimicrobial and immunomodulatory properties. Nevertheless, there is a possibility of negative effects of NPs on MSCs.</div> <div><strong>Methods</strong></div> <div>In this study, we tested the <em>in vitro</em> and <em>in vivo</em> effect of silver (Ag) NPs on the properties of MSCs in an experimental mouse model of chronic retinal degeneration induced by sodium iodate.</div> <div><strong>Results</strong></div> <div>The results showed that simultaneous intravitreal administration of MSCs with AgNPs had no effect on the survival of MSCs in the eye, but a less effective regulation of Iba-1 (activated microglia/macrophages) and interleukin-1β expression in the retinal tissue compared to MSCs or AgNP only treated groups was observed. However, all treated groups had decreased expression of the gene for galectin-3 compared to the untreated control. In addition, MSCs applied alone or in combination with AgNPs and sorted from the degenerated retina on day 7 after application had increased expression of genes for specific retinal markers, and for transforming growth factor-β and insulin-like growth factor-1 compared to untreated naïve MSCs. On the contrary, the increased expression of the gene for glial cell-derived growth factor was observed only in the MSCs combined with AgNPs. However, the application of MSCs with AgNPs triggered increased expression for the IL-6 gene in the CD45 cells separated from the retina.</div> <div><strong>Conclusion</strong></div> <div>Overall, the results show that the application of MSCs or AgNPs has an immunomodulatory effect in chronic retinal degeneration, but the combined application of MSCs and AgNPs could decrease the effects of a single therapy.</div>
Lanreotide Autogel and Pegvisomant Combination Therapy in Acromegalic Patients
ClinicalTrials.gov study NCT00383708. IPD Sharing: YES. Countries: 10. Publications: 1.
Study to Compare the Combination of Ribociclib Plus Goserelin Acetate With Hormonal Therapy Versus Combination Chemotherapy in Premenopausal or Perimenopausal Patients With Advanced or Metastatic Brea
ClinicalTrials.gov study NCT03839823. IPD Sharing: YES. Countries: 13. Publications: 1.
Safety and Efficacy Study of a Triple Combination Therapy in Subjects With Hypertension
ClinicalTrials.gov study NCT00649389. IPD Sharing: YES. Countries: 2. Publications: 4.
Effectiveness of Combining Behavioral and Pharmacologic Therapy for Complex Insomnia in Veterans With PTSD
ClinicalTrials.gov study NCT03937713. IPD Sharing: YES. Countries: 1. Publications: 1.
Study of Safety, Efficacy and Tolerability of Secukinumab Versus Placebo, in Combination With SoC Therapy, in Patients With Active Lupus Nephritis
ClinicalTrials.gov study NCT04181762. IPD Sharing: YES. Countries: 34. Publications: 2.
Triple Combination Therapy in High Risk Crohn's Disease (CD)
ClinicalTrials.gov study NCT02764762. IPD Sharing: YES. Countries: 2. Publications: 1.
Evaluation of SAR440340 and as Combination Therapy With Dupilumab in Moderate-to-Severe Asthma Participants
ClinicalTrials.gov study NCT03387852. IPD Sharing: YES. Countries: 8. Publications: 2.
A Study of SAR444245 Combined With Other Anticancer Therapies for the Treatment of Participants With Gastrointestinal Cancer (Master Protocol) (Pegathor Gastrointestinal 203)
ClinicalTrials.gov study NCT05104567. IPD Sharing: YES. Countries: 9. Publications: 0.
Phase III Study Evaluating Efficacy and Safety of Canakinumab in Combination With Docetaxel in Adult Subjects With Non-small Cell Lung Cancers as a Second or Third Line Therapy
ClinicalTrials.gov study NCT03626545. IPD Sharing: YES. Countries: 26. Publications: 1.
Study of Selective BRAF Kinase Inhibitor Dabrafenib Monotherapy Twice Daily and in Combination With Dabrafenib Twice Daily and Trametinib Once Daily in Combination Therapy in Subjects With BRAF V600E
ClinicalTrials.gov study NCT01336634. IPD Sharing: YES. Countries: 11. Publications: 5.
Efficacy and Safety of the Combination Therapy of Dabrafenib and Trametinib in Subjects With BRAF V600E- Mutated Rare Cancers
ClinicalTrials.gov study NCT02034110. IPD Sharing: YES. Countries: 14. Publications: 8.
Phase 1/2 Study of Amcenestrant (SAR439859) Single Agent and in Combination With Other Anti-cancer Therapies in Postmenopausal Women With Estrogen Receptor Positive Advanced Breast Cancer
ClinicalTrials.gov study NCT03284957. IPD Sharing: YES. Countries: 10. Publications: 1.
Overcoming clinical resistance to EZH2 inhibition using rational epigenetic combination therapy
<p>Supplementary data for Kazansky et al, "Overcoming clinical resistance to EZH2 inhibition using rational epigenetic combination therapy" and "Epigenetic targeting of PGBD5-dependent DNA damage in SMARCB1-deficient sarcomas." Raw RNA-seq data from G401 cells can be found at the Gene Expression Omnibus (GEO) repository, accession number GSE213845. RNA-seq data from patient tumor samples has been deposited to the Database of Genotypes and Phenotypes (dbGaP), accession number phs003188.v1.p1.</p> <p>All files are labeled with their corresponding figures.</p> <p>"DESeq_processing_FINAL.R" was used for analysis of patient RNA-seq data, using "20230131_SampleTable.csv" and all "*_htseq.txt" files as input.</p> <p>"Tumor_growth_analysis_FINAL_UPDATED" was used for analysis of tumor growth kinetics using the aucVardiTest function. This was used for both of the manuscripts desscribed above.</p>
Data sets used to demonstrate the software MadHitter in the manuscript "The Landscape of Receptor-Mediated Precision Cancer Combination Therapy Via a Single-Cell Perspective"
<p>This is a zip archive of nine single-cell RNASeq data sets used in the manuscript entitled:</p> <p>"The Landscape of Receptor-Mediated Precision Cancer Combination Therapy Via A Single-Cell Perspective" by Saba Ahmadi, Pattara Sukprasert, Rahulsimham Vegesna, Sanju Sinha, Fiorella Schischlik, Natalie Artzi, Samir Khuller, Alejandro A. Schaffer, Eytan Ruppin,</p> <p>The README.txt describes the data sets in detail.</p> <p>The associated software can be found at https://github.com/ruppinlab/madhitter</p>
COLUMBIA-1: Novel Oncology Therapies in Combination With Chemotherapy and Bevacizumab as First- Line Therapy in MSS-CRC
ClinicalTrials.gov study NCT04068610. IPD Sharing: YES. Countries: 5. Publications: 1.
Study of the Safety and Contraceptive Efficacy of Relugolix Combination Therapy in Women With Uterine Fibroids or Endometriosis Who Are at Risk for Pregnancy
ClinicalTrials.gov study NCT04756037. IPD Sharing: NO. Countries: 2. Publications: 1.
Efficacy and Safety of FIAsp in a Basal-bolus Regimen Versus Basal Insulin Therapy, Both in Combination With Metformin in Adult Subjects With Type 2 Diabetes
ClinicalTrials.gov study NCT01850615. IPD Sharing: Not stated. Countries: 6. Publications: 4.
Safety and Efficacy of Triple Combination Therapy in Patients With Primary Open-Angle Glaucoma or Ocular Hypertension
ClinicalTrials.gov study NCT01241240. IPD Sharing: Not stated. Countries: 2. Publications: 1.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.