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215 results for “convalescent”
Multi-omics identify LRRC15 as a COVID-19 severity predictor and persistent pro-thrombotic signals in convalescence
<p>RNA sequencing, SomaLogic proteomics and flow cytometry data were generated for two cohorts of end-stage kidney disease patients with COVID-19. The Wave 1 cohort consists of samples collected from patients during the first wave of COVID-19 in early 2020, while samples were collected for the Wave 2 cohort in the following year.</p> <p>This data deposition includes the RNA-seq counts, SomaScan proteomics, flow cytometry and clinical metadata associated with the study. For further information about the study and data, see the associated GitHub repository (https://github.com/jackgisby/covid-longitudinal-multi-omics) or our pre-print (https://doi.org/10.1101/2022.04.29.22274267). The repository also contains code to replicate our analysis of the data.</p> <p>The raw RNA-seq reads were processed using the nf-core RNA-seq v3.2 pipeline before htseq-count was used to generate a raw counts matrix, which is included in this deposition (<code>htseq_counts.csv</code>). Three files make up the proteomics data: <code>sample_technical_meta.csv</code>, <code>feature_meta.csv</code> and <code>soma_abundance.csv</code>. The first two files contain metadata columns for the samples and protein features, respectively. The final file includes the unprocessed protein abundance data. The files <code>general_panel.csv</code> and <code>t_cell_panel.csv</code> contain the flow cytometry data, split into the general and T-cell panels, respectively. Finally, clinical metadata is available for the two cohorts described in this study (<code>w1_metadata.csv</code>, <code>w2_metadata.csv</code>).</p> <p>The features in the clinical metadata include:</p> <table> <thead> <tr> <th>Column Name</th> <th>Data Type</th> <th>Description</th> </tr> </thead> <tbody> <tr> <td>sample_id</td> <td>Character</td> <td>Unique identifier for samples</td> </tr> <tr> <td>individual_id</td> <td>Character</td> <td>Unique identifier for individuals</td> </tr> <tr> <td>ethnicity</td> <td>Character</td> <td>The individual's ethnicity (asian, white, black or other)</td> </tr> <tr> <td>sex</td> <td>Character</td> <td>The individual's sex (M or F)</td> </tr> <tr> <td>calc_age</td> <td>Integer</td> <td>Age in years</td> </tr> <tr> <td>ihd</td> <td>Character</td> <td>Information on coronary heart disease</td> </tr> <tr> <td>previous_vte</td> <td>Character</td> <td>Whether individuals have had venous thromboembolism</td> </tr> <tr> <td>copd</td> <td>Character</td> <td>Whether individuals have chronic obstructive pulmonary disease</td> </tr> <tr> <td>diabetes</td> <td>Character</td> <td>Whether individuals have diabetes, and, if so, the type of diabetes</td> </tr> <tr> <td>smoking</td> <td>Character</td> <td>Smoking status</td> </tr> <tr> <td>cause_eskd</td> <td>Character</td> <td>Cause of ESKD</td> </tr> <tr> <td>WHO_severity</td> <td>Character</td> <td>The peak (WHO) severity for the patient over the disease course</td> </tr> <tr> <td>WHO_temp_severity</td> <td>Character</td> <td>The (WHO) severity at time of sampling</td> </tr> <tr> <td>fatal_disease</td> <td>Logical</td> <td>Whether the disease was fatal</td> </tr> <tr> <td>case_control</td> <td>Character</td> <td>Whether the individual was COVID-19 <code>POSITIVE</code> or <code>NEGATIVE</code> at time of sampling. Convalescent patients are denoted by the label <code>RECOVERY</code></td> </tr> <tr> <td>radiology_evidence_covid</td> <td>Character</td> <td>Evidence of COVID-19 from radiology</td> </tr> <tr> <td>time_from_first_symptoms</td> <td>Integer</td> <td>The number of days since the individual first experienced COVID symptoms at time of sampling</td> </tr> <tr> <td>time_from_first_positive_swab</td> <td>Integer</td> <td>The number of days since the individual's first positive swab was taken at time of sampling</td> </tr> </tbody> </table>
ROB 2 assessments_Convalescent plasma or hyperimmune immunoglobulin for people with COVID-19_a living systematic review
<p>Risk of bias assessments and support for judgement with ROB 2 tool for the Cochrane Review: Convalescent plasma or hyperimmune immunoglobulin for people with COVID-19:a living systematic review (Version 3). </p>
Risk of bias assessments for version 5 of the Cochrane review 'Convalescent plasma for people with COVID-19'
<p>Risk of bias assessments and support for judgement with ROB 2 tool for the Cochrane Living Systematic Review: Convalescent plasma for people with COVID-19 (Version 5). </p>
Observational Study of Convalescent Plasma for Treatment of Veterans With COVID-19
ClinicalTrials.gov study NCT04545047. IPD Sharing: NO. Countries: 1. Publications: 1.
Single-cell immune repertoire sequencing of two convalescent COVID-19 patients
<p>Single-cell immune repertoire sequencing of two convalescent COVID-19 patients using 10x genomics 5' immune profiling. Resulting output files are from the count and vdj functions from 10x genomic's cellranger v3.1.0. </p>
Source data for Neutralization of SARS-CoV-2 variants by convalescent and BNT162b2 vaccinated serum
<p>This dataset contains the source data used in the publication: "Neutralization of SARS-CoV-2 variants by convalescent and BNT162b2 vaccinated serum" published in Nature communications on August 26, 2021 (10.1038/s41467-021-25479-6).</p>
Transcriptome profiling of human monocytes from accute phase and convalescent patients infected with Plasmodium vivax malaria
<p> RNA sequencing raw data of monocytes obtained from five patients in acute phase of <em>Plasmodium vivax </em>malaria and 45 days after treatment. Individuals from Rondônia (Brazil) were between 18 and 60 years and attended to the exclusion criteria: chronic inflammatory or infectious diseases, pregnancy, and breastfeeding. Diagnostic of malaria by clinical symptoms and thick blood smear was also confirmed by qPCR. According to the recommended protocol of the Brazilian Ministry of Health patients were treated with chloroquine associated to primaquine. Protocols used were approved by the Ethical Committees on Human Experimentation from Instituto Rene ́ Rachou, Fiocruz, and National Ethical Council (CAAE: 59902816.7.0000.5091). </p> <p> Sequencing was performed in a NextSeq 500 system using the NextSeq 500/550 High Output Kit v2.5 for 75 cycles (both from Illumina). Before sequencing total mRNA samples were prepared using TruSeq Stranded mRNA Kit (Illumina) according to the manufacturer’s protocol. Files are in FASTQ format, just as they were downloaded from Illumina's cloud environment (BaseSpace) right after sequencing. Files are identified by patient number (1 to 5) and health condition: acute phase of the disease or convalescent (45 days after treatment).</p>
Convalescent Plasma as Treatment for Subjects With Early COVID-19 Infection
ClinicalTrials.gov study NCT04456413. IPD Sharing: NO. Countries: 1. Publications: 22.
COVID-19 Convalescent Plasma
ClinicalTrials.gov study NCT04340050. IPD Sharing: YES. Countries: 1. Publications: 4.
Treatment With Investigational Convalescent Plasma and Measure Antibody Levels in Patients Hospitalized With COVID-19
ClinicalTrials.gov study NCT04434131. IPD Sharing: NO. Countries: 1. Publications: 5.
Convalescent Plasma for Early Treatment of COVID-19
ClinicalTrials.gov study NCT04390503. IPD Sharing: NO. Countries: 1. Publications: 7.
CONvalescent Plasma for Hospitalized Adults With COVID-19 Respiratory Illness (CONCOR-1)
ClinicalTrials.gov study NCT04348656. IPD Sharing: NO. Countries: 3. Publications: 3.
Convalescent Plasma in the Early Treatment of High-Risk Patients With SARS-CoV-2 (COVID-19) Infection
ClinicalTrials.gov study NCT04513158. IPD Sharing: NO. Countries: 1. Publications: 38.
COVID-19 Convalescent Plasma for the Treatment of Hospitalized Patients With Pneumonia Caused by SARS-CoV-2.
ClinicalTrials.gov study NCT04397757. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Emergency Evaluation of Convalescent Plasma for Ebola Viral Disease (EVD) in Guinea
ClinicalTrials.gov study NCT02342171. IPD Sharing: Not stated. Countries: 1. Publications: 3.
Efficacy of Reinforcing Standard Therapy in COVID-19 Patients With Repeated Transfusion of Convalescent Plasma
ClinicalTrials.gov study NCT04803370. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Therapeutic Plasma Exchange Followed by Convalescent Plasma Transfusion in Severe and Critically Ill COVID-19 Patients
ClinicalTrials.gov study NCT04973488. IPD Sharing: YES. Countries: 1. Publications: 1.
Convalescent Plasma to Limit SARS-CoV-2 Associated Complications
ClinicalTrials.gov study NCT04373460. IPD Sharing: YES. Countries: 1. Publications: 5.
Convalescent Plasma in Outpatients With COVID-19
ClinicalTrials.gov study NCT04355767. IPD Sharing: YES. Countries: 1. Publications: 1.
Determinants of SARS (Severe Acute Respiratory Syndrome)-COV2 (COVID-19) Persistence After Convalescence
ClinicalTrials.gov study NCT04448145. IPD Sharing: UNDECIDED. Countries: 1. Publications: 13.
ScienceDex guides
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OpenNeuro
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