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8 results for “cosmic radiation”
Dataset for Accessing Cosmic Radiation as an Entropy Source for a Non-Deterministic Random Number Generator
<p>The dataset contains all gathered data from the experiment from Wednesday, March 16, 2022 11:58:41.929 AM UTC+0 (1647431921929) until Sunday, April 3, 2022 1:08:35.353 PM UTC+0 (1648991315353). The experiment was executed during physical presence within the Arctic Circle in Tromsø, Norway 69° 40' 53.117'' N 18° 58' 36.027'' E at 35m elevation above sea level. The dataset was gathered with a prototype [1] based on the CREDO android application [2]. The main research is to use Ultra High Energy Cosmic Rays (UHECR) as an entropy source for a Random Bit Generator (RBG). </p> <p>The associated publication will probably have the title "Accessing Cosmic Radiation as an Entropy Source for a Non-Deterministic Random Number Generator"</p> <p>In order to reproduce the results the SQLite3 database "mrng_arctic_experiment_2022.db" is needed. To get the visual representations of the detections use "image_decoding_and_codesnippets.py" to generate the cleaned (414 detections / ~15MB) or the uncleaned (5567 detections / ~195 MB) dataset. The compressed folder "raw_data_incl_space_weather.7z" contains all raw data as gathered with the MRNG prototype, unprocessed, uncleaned, and unmerged. </p> <p> </p> <p>[1] https://github.com/StefanKutschera/mrng-prototype, visited on 27.03.2023</p> <p>[2] https://github.com/credo-science/credo-detector-android, visited on 27.03.2023</p>
Study of Markers of Cosmic Radiation Exposure and Effect Among Flight Crews
ClinicalTrials.gov study NCT00341900. IPD Sharing: Not stated. Countries: 1. Publications: 3.
Galactic cosmic radiation induces stable epigenome alterations relevant to human lung cancer
Human deep space and planetary travel is limited by uncertainties regarding the health risks associated with exposure to galactic cosmic radiation (GCR) and in particular the high linear energy transfer (LET) heavy ion component. Here we assessed the impact of two high-LET ions 56Fe and 28Si and low-LET X rays on genome-wide methylation patterns in human bronchial epithelial cells. We found that all three radiation types induced rapid and stable changes in DNA methylation but at distinct subsets of CpG sites affecting different chromatin compartments. The 56Fe ions induced mostly hypermethylation and primarily affected sites in open chromatin regions including enhancers promoters and edges ( shores ) of CpG islands. The 28Si ion-exposure had mixed effects inducing both hyper and hypomethylation and affecting sites in more repressed heterochromatic environments whereas X rays induced mostly hypomethylation primarily at sites in gene bodies and intergenic regions. Significantly the methylation status of 56Fe ion irradiation sensitive sites but not those affected by X ray or 28Si ions could discriminate tumor from normal tissue for human lung adenocarcinomas and squamous cell carcinomas. Thus high LET radiation exposure leaves a lasting imprint on the epigenome and affects sites relevant to human lung cancer. The 56Fe ion signature may prove useful in monitoring the cumulative biological impact and associated cancer risks encountered by astronauts in deep space. Genome wide DNA methylation profiling of normal human bronchial epithelial cells irradiated with varying doses of 28Si-ion radiation ( 300 MeV/u at 0 0.3 1.0 Gy) 56Fe-ion radiation (600 MeV/u at 0 0.1 0.3 1.0 Gy) or X rays (320 kV at 0 1.0 Gy). Triplicate control and irradiated samples were incubated and sampled at 4 timepoints between 2 and 62 days. The Illumina Infinium 450k Human DNA methylation Beadchip was used to obtain DNA methylation profiles across >485,000 CpGs from collected samples. Samples include: 56Fe ions 4 doses x 4 time points x 3 replicates (4 removed in QC) = 44 samples; 28Si ions = 3 doses x 4 time points x 3 replicates = 36 samples; X ray 2 doses x 4 time points x 3 replicates (2 removed in QC)= 22 samples. Overall design: Bisulphite converted DNA from the 102 samples were hybridized to the Illumina Infinium 450k Human Methylation Beadchip.
Galactic cosmic radiation induces stable epigenome alterations relevant to human lung cancer
GEO Series GSE108187. Homo sapiens. 102 samples. Type: Methylation profiling by genome tiling array.
Approaches for Surveying Cosmic Radiation Damage in Large Populations of Arabidopsis thaliana Seeds- an Antarctic Example
The Cosmic Ray Exposure Sequencing Science (CRESS) payload system is a proof of concept experiment to assess the genomic impact of space radiation on seeds. CRESS was designed as a secondary payload for the December 2016 high-altitude high-latitude and long-duration balloon flight carrying the Boron And Carbon Cosmic Rays in the Upper Stratosphere (BACCUS) experimental hardware. Investigation of the biological effects of Galactic Cosmic Radiation (GCR) particularly those of ions with High-Z and Energy (HZE) is of interest due to the genomic damage this type of radiation inflicts. The biological effects of upper-stratospheric mixed radiation above Antarctica (ANT) were sampled using Arabidopsis thaliana seeds and were compared to those resulting from a controlled simulation of GCR at Brookhaven National Laboratory (BNL) and to laboratory control seed. The payload developed for Antarctica exposure was broadly designed to 1U CubeSat specifications (10cmx10cmx10cm <1.33kg) maintained 1 atm internal pressure and carried an internal cargo of four seed trays (about 580,000 seeds) and twelve CR-39 Solid-State Nuclear Track Detectors (SSNTDs). The irradiated seeds were recovered sterilized and grown on Petri plates for phenotypic screening. BNL and ANT M0 seeds showed significantly reduced germination rates and elevated somatic mutation rates when compared to non-irradiated controls with the BNL mutation rate also being significantly higher than that of ANT. Genomic DNA from mutants of interest was evaluated with whole-genome sequencing using PacBio SMRT technology. Sequence data revealed the presence of an array of genome structural variants in the genomes of M0 and M1 mutant plants.
Effect of simulated galactic cosmic radiation on mouse lung gene expression
GEO Series GSE199680. Mus musculus. 37 samples. Type: Expression profiling by high throughput sequencing.
Single-cell transcriptomic profiling reveals sex-specific microglial responses to simulated galactic cosmic radiation without classical inflammatory activation
GEO Series GSE315315. Mus musculus. 4 samples. Type: Expression profiling by high throughput sequencing.
Approaches for Surveying Cosmic Radiation Damage in Large Populations of Arabidopsis thaliana Seeds- an Antarctic Example
GEO Series GSE121111. Arabidopsis thaliana. 5 samples. Type: Genome variation profiling by high throughput sequencing.
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
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DANDI Archive for NWB datasets
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International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.