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37
datasets available to search
ShareScore release 0.9.0
Dataset results
37 results for “covalent inhibitor”
Candidate compounds from the design of covalent Bruton's tyrosine kinase (BTK) inhibitors via focused deep generative modeling
<pre>A total of 1491 candidate inhibitors for covalent inhibition of BTK are deposited as SMILES strings together with 34 known covalent BTK inhibitors used to guide generative computational design. The study will be reported in a publication in Molecules under the authors' names.</pre>
Dynamics Playing a Key Role in the Covalent Binding of Kinase Inhibitors to the Focal Adhesion Kinase
Open the record for dataset details and reuse information.
Supporting simulation data for "4-Oxo-β-lactams as Covalent Inhibitors of the Mitochondrial Intramembrane Protease PARL"
<p>Molecular dynamics input and output files and covalent docking poses of the PARL protease.</p>
Identification of covalent small-molecule inhibitors of STING
GEO Series GSE113933. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing.
A novel covalent inhibitor of CDK7 synergizes with Venetoclax in acute myeloid leukemia
GEO Series GSE231745. Homo sapiens. 8 samples. Type: Expression profiling by high throughput sequencing.
Development of Specific Covalent MALT1 Inhibitors and Biomarkers for B-cell Lymphomas
GEO Series GSE108293. Homo sapiens. 42 samples. Type: Expression profiling by high throughput sequencing.
Discovery of BBO-8520, a first-in-class direct and covalent dual inhibitor of GTP-bound (ON) and GDP-bound (OFF) KRASG12C
GEO Series GSE278656. Homo sapiens. 20 samples. Type: Expression profiling by high throughput sequencing.
Anti-tumor efficacy of a potent and selective non-covalent KRASG12D inhibitor
GEO Series GSE201412. Homo sapiens. 105 samples. Type: Expression profiling by high throughput sequencing.
Targeting KRAS mutant cancers with a covalent G12C-specific inhibitor
GEO Series GSE103021. Homo sapiens. 32 samples. Type: Expression profiling by high throughput sequencing.
Development of a selective CDK7 covalent inhibitor reveals predominant cell cycle phenotype
GEO Series GSE124607. Homo sapiens. 42 samples. Type: Expression profiling by high throughput sequencing.
Inhibition of Thiol-Mediated Uptake with Irreversible Covalent Inhibitors
<p>Original data</p>
A Study to Evaluate the Effect of Venetoclax on Participants Receiving a Covalent Bruton's Tyrosine Kinase Inhibitor (cBTKi) for First-line Chronic Lymphocytic Leukemia (1L CLL) to Achieve Deep Durabl
ClinicalTrials.gov study NCT06524375. IPD Sharing: YES. Countries: 1. Publications: 0.
Covalent Tolerance Induction to Factor VIII-Prediction of Inhibitors in Hemophilia
ClinicalTrials.gov study NCT00178607. IPD Sharing: YES. Countries: 1. Publications: 0.
Study of Covalent Menin Inhibitor BMF-219 in Adult Patients With KRAS Driven Non-Small Cell Lung Cancer, Pancreatic Cancer, and Colorectal Cancer
ClinicalTrials.gov study NCT05631574. IPD Sharing: Not stated. Countries: 2. Publications: 0.
Pirtobrutinib in Combination With Rituximab, Gemcitabine, Oxaliplatin With or Without Polatuzumab Vedotin in Covalent BTK Inhibitor-Pretreated Relapsed/Refractory Diffuse Large B-Cell Lymphoma
ClinicalTrials.gov study NCT07122609. IPD Sharing: NO. Countries: 1. Publications: 0.
Study of BMF-219, a Covalent Menin Inhibitor, in Adult Patients With AML, ALL (With KMT2A/ MLL1r, NPM1 Mutations), DLBCL, MM, and CLL/SLL
ClinicalTrials.gov study NCT05153330. IPD Sharing: NO. Countries: 5. Publications: 0.
Targeting transcriptional dependencies in cancer using a covalent CDK7 inhibitor
GEO Series GSE50625. Homo sapiens. 92 samples. Type: Expression profiling by array; Genome binding/occupancy profiling by high throughput sequencing.
Targeting transcriptional dependencies in cancer using a covalent CDK7 inhibitor (ChIP-Seq)
GEO Series GSE50622. Homo sapiens. 13 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Covalent targeting of remote cysteine residues to develop CDK12 and CDK13 inhibitors [ChIP-Seq]
GEO Series GSE72023. Homo sapiens. 7 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Covalent targeting of remote cysteine residues to develop CDK12 and CDK13 inhibitors
GEO Series GSE72031. Homo sapiens. 4 samples. Type: Expression profiling by array; Genome binding/occupancy profiling by high throughput sequencing.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.