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14 results for “cucurbitacins”
Fig. 4 in Identification of seven undescribed cucurbitacins in Cucumis sativus (cucumber) and their cytotoxic activity
Fig. 4. Cucurbitacins induced caspase apoptosis pathway activation in HepG2 cells. (A) Apoptosis induction effects of four cucurbitacins on HepG2 cells. The cells were treated with each cucurbitacin for 24 h, and stained with Hoechst 33258 for cell apoptosis assay. Arrows, chromatin condensed HepG2 cells. (B) Quantitative data of panel A, percentage of apoptosis cells is shown. **P <0.01, ***P <0.001, student t-test. (C) Inhibition effects of four cucurbitacins in caspase apoptosis pathway on HepG2 cells. The cells were treated with each cucurtibitcin for 24 h, respectively, and the major apoptosis-related proteins (PARP, cleaved PARP, Caspase-9, Caspase-8 and Caspase-3) were detected by Western blot. β-actin was used as internal reference. (D) Quantitative data of panel C, expression levels of apoptosis-related proteins are shown. **P <0.01, ***P <0.001, student t-test.
Fig. 6 in Pentacyclic and hexacyclic cucurbitacins from Elaeocarpus petiolatus
Fig. 6. Viral entry inhibition assay using influenza HA pseudotyped virus showing (a) the mean and standard deviation of relative light units (RLU) per ml (triplicate wells from a representative assay) caused by compounds 4–6 relative to the virus-only control (shown by dotted line); and (b) the calculated mean percentage inhibition relative to the virus-only control.
Fig. 3. Key HMBC,1H–1H in Identification of seven undescribed cucurbitacins in Cucumis sativus (cucumber) and their cytotoxic activity
Fig. 3. Key HMBC,1H–1H COSY, NOESY correlations and energy-minimized 3D structures of 1 and 10.
Fig. 1 in Identification of seven undescribed cucurbitacins in Cucumis sativus (cucumber) and their cytotoxic activity
Fig. 1. Typical cucurbitacins isolated from the planta of Cucurbitaceae.
Fig. 5 in Pentacyclic and hexacyclic cucurbitacins from Elaeocarpus petiolatus
Fig. 5. Plausible biosynthetic pathway to compounds 1 and 2 from cucurbitacin F (9).
Fig. 2. 1H–1H in Pentacyclic and hexacyclic cucurbitacins from Elaeocarpus petiolatus
Fig. 2. 1H–1H COSY and selected HMBC correlations of compounds 1–4.
Fig. 4. X in Pentacyclic and hexacyclic cucurbitacins from Elaeocarpus petiolatus
Fig. 4. X-ray crystal structure of compound 1.
Fig. 3 in Pentacyclic and hexacyclic cucurbitacins from Elaeocarpus petiolatus
Fig. 3. Selected NOESY correlations of compounds 1–3.
Fig. 3. Cucurbitacin B in Modulation of cellular circadian clocks by triterpenoids
Fig. 3. Cucurbitacin B resets the circadian clocks in U2OS, NIH3T3, and mouse tissue explants.
In vitro and in vivo antitumor activity of cucurbitacin C, a novel natural product from cucumber
GEO Series GSE138367. Homo sapiens. 4 samples. Type: Expression profiling by high throughput sequencing.
Cucurbitacin B-induced G2/M cell cycle arrest of conjunctival melanoma cells mediated by GRP78-FOXM1-KIF20A pathway
GEO Series GSE192359. Homo sapiens. 9 samples. Type: Expression profiling by high throughput sequencing.
Fig. 2 in Identification of seven undescribed cucurbitacins in Cucumis sativus (cucumber) and their cytotoxic activity
Fig. 2. Cucurbitacins isolated from the leaves of cucumber.
High-throughput sequencing of SCC9 in normal cells and Cucurbitacin B treated cells
GEO Series GSE179015. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing; Non-coding RNA profiling by high throughput sequencing.
RNA sequencing of murine ESC-derived cardiac progenitor cells treated with screening hit compound Cucurbitacin I Hydrate
GEO Series GSE128609. Mus musculus. 4 samples. Type: Expression profiling by high throughput sequencing.
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Allen Brain Atlas
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DANDI Archive for NWB datasets
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International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.