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21
datasets available to search
ShareScore release 0.9.0
Dataset results
21 results for “cyclooxygenase-2”
Cyclooxygenase-2 (COX-2) Inhibitor Reduces Serum Prostatic Specific Antigen (PSA) Levels
ClinicalTrials.gov study NCT01678313. IPD Sharing: Not stated. Countries: 1. Publications: 13.
Cyclooxygenase-2-Inhibitor Combination Treatment for Bipolar Depression
ClinicalTrials.gov study NCT01479829. IPD Sharing: NO. Countries: 1. Publications: 2.
Secondary Primary Tumor Prevention With EGFR, OSI-774, and Cyclooxygenase-2
ClinicalTrials.gov study NCT00400374. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Cyclooxygenase-2 Inhibitor for Adjuvant Anticancer Effect in Patients With Biliary-pancreas Cancer
ClinicalTrials.gov study NCT01111591. IPD Sharing: UNDECIDED. Countries: 1. Publications: 1.
Effects of Dual Cyclooxygenase-2 and Carbonic Anhydrase Inhibition
ClinicalTrials.gov study NCT00780325. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Opposing Effects of Cyclooxygenase-2 (COX-2) on Estrogen Receptor β (ERβ) Response to 5α-reductase Inhibition in Prostate Epithelial Cells
GEO Series GSE80979. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
Potential cyclooxygenase-2-independent mechanisms of the anti-proliferation and anti-fibrotic effects of celecoxib on the human intrahepatic biliary epithelial cell line HIBEpiC assessed by bulk-RNA s
GEO Series GSE220643. Homo sapiens. 12 samples. Type: Expression profiling by high throughput sequencing.
Interaction between cyclooxygenase-2 and caspase-3 abolishes the cleavage of RNA-binding protein HuR and promotes drug resistance in oral squamous cell carcinoma
GEO Series GSE79477. Homo sapiens. 4 samples. Type: Expression profiling by high throughput sequencing.
The vascular endothelial thromboxane A2/prostaglandin H2 receptor controls its own activation and impairs angiogenesis via an autocrine cyclooxygenase-2-dependent positive feedback loop.
GEO Series GSE146888. Homo sapiens. 9 samples. Type: Expression profiling by high throughput sequencing.
Cyclooxygenase-2-Associated Factors and Gastric Carcinogenesis Mechanisms-Clinical Association and Genomic Investigation
ClinicalTrials.gov study NCT00172861. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Analgesia in Inguinal Hernia Repair Using a Cyclooxygenase-2-specific Inhibitor
ClinicalTrials.gov study NCT02884986. IPD Sharing: YES. Countries: 1. Publications: 0.
Statins and Selective Cyclooxygenase-2 Receptor Inhibitors in Blunt Chest Trauma
ClinicalTrials.gov study NCT01623921. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Effects of Cyclooxygenase (COX) 1-2 Inhibitors on Prevention of Rocuronium Injection Pain
ClinicalTrials.gov study NCT04582032. IPD Sharing: NO. Countries: 1. Publications: 0.
Perioperative Inflammation and Cyclooxygenase 2 (COX-2)
ClinicalTrials.gov study NCT00122096. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Microarray studies on genes stimulated by RANKL in bone marrow macrophages in a cyclooxygenase-2-dependent manner
GEO Series GSE72047. Mus musculus. 26 samples. Type: Expression profiling by array.
Cyclooxygenase-2 Expression in Tissue Samples From Patients With a Normal Cervix, Cervical Intraepithelial Neoplasia, or Early Invasive Cervical Cancer
ClinicalTrials.gov study NCT00900081. IPD Sharing: Not stated. Countries: 0. Publications: 0.
Association and Mechanism Between Cyclooxygenase-2 and Interleukin-6 in Gastric Cancer
ClinicalTrials.gov study NCT00172627. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Indazole-Cl inhibition of hypoxia-induced cyclooxygenase-2 expression in vascular smooth muscle cells
GEO Series GSE113940. Rattus norvegicus. 5 samples. Type: Expression profiling by high throughput sequencing.
Dataset related to the article: "Cyclooxygenase-2 Glycosylation Is Affected by Peroxynitrite in Endothelial Cells: Impact on Enzyme Activity and Degradation"
<p>This record containsraw data related to the article: "Cyclooxygenase-2 Glycosylation Is Affected by Peroxynitrite in Endothelial Cells: Impact on Enzyme Activity and Degradation"</p> <p>Abstract: The exposure of human endothelial cells to 3-morpholinosydnonimine (SIN-1) induced the<br> expression of cyclooxygenase-2 (COX-2) in a dose- and time-dependent manner. Interestingly, after a<br> prolonged incubation (>8 h) several proteoforms were visualized by Western blot, corresponding<br> to different states of glycosylation of the protein. This effect was specific for SIN-1 that generates<br> peroxynitrite and it was not detected with other nitric oxide-donors. Metabolic labeling experiments<br> using 35S or cycloheximide suggested that the formation of hypoglycosylated COX-2 was dependent<br> on de novo synthesis of the protein rather than the deglycosylation of the native protein. Moreover,<br> SIN-1 reduced the activity of the hexokinase, the enzyme responsible for the first step of glycolysis.<br> The hypoglycosylated COX-2 induced by SIN-1 showed a reduced capacity to generate prostaglandins<br> and the activity was only partially recovered after immunoprecipitation. Finally, hypoglycosylated<br> COX-2 showed a more rapid rate of degradation compared to COX-2 induced by IL-1a and an<br> alteration in the localization with an accumulation mainly detected in the nuclear membrane. Our<br> results have important implication to understand the effect of peroxynitrite on COX-2 expression<br> and activity, and they may help to identify new pharmacological tools direct to increase COX-2<br> degradation or to inhibit its activity.</p>
Hepatocytes cyclooxygenase-2 deficiency improves liver injury via inhibition of endoplasmic reticulum stress and epithelial-mesenchymal transition
GEO Series GSE183888. Mus musculus. 9 samples. Type: Expression profiling by high throughput sequencing.
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Allen Brain Atlas
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The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
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