Find research datasets worth reusing
Search datasets from major research repositories and use ShareScore to quickly assess how well each record supports discovery, access, and reuse.
151
datasets available to search
ShareScore release 0.9.0
Dataset results
151 results for “cytokine expression”
Data from: Behavioural infection tolerance of malaria is negatively correlated with pro-inflammatory cytokine expression in the brain of an invasive songbird
Open the record for dataset details and reuse information.
Exprimental Data:Caspase-11 non-canonical inflammasome mediates the expression of proinflammatory cytokines in murine macrophages infected with leptospira interrogans.
<p>This is the exprimental data of manuscripts submitted in ALL LIFE magazine. The title is Caspase-11 non-canonical inflammasome mediates the expression of proinflammatory cytokines in murine macrophages infected with leptospira interrogans.)</p>
Figure 1 in Detection of respiratory viruses and expression of inflammatory cytokines in patients with acute exacerbation chronic obstructive pulmonary disease in Mongolia China
Figure 1. Distribution of Viruses.
Relationships between immune gene expression and circulating cytokine levels in wild house mice
<p>1. Quantitative PCR (qPCR) has been commonly used to measure gene expression in a number of research contexts, but the measured RNA concentrations do not always represent the concentrations of active proteins which they encode. This can be due to transcriptional regulation or post-translational modifications, or localisation of immune environments, as can occur during infection. However, in studies using free-living non-model species, such as in ecoimmunological research, qPCR may be the only available option to measure a parameter of interest, and so understanding the quantitative link between gene expression and associated effector protein levels is vital.</p> <p>2. Here we use qPCR to measure concentrations of RNA from mesenteric lymph node (MLN) and spleen tissue, and multiplex ELISA of blood serum to measure circulating cytokine concentrations in a wild population of a model species, Mus musculus domesticus.</p> <p>3. Few significant correlations were found between gene expression levels and circulating cytokines of the same immune genes or proteins, or related functional groups. Where significant correlations were observed, these were most frequently within the measured tissue (i.e. the expression levels of genes measured from spleen tissue were more likely to correlate with each other rather than with genes measured from MLN tissue, or with cytokine concentrations measured from blood).</p> <p>4. Potential reasons for discrepancies between measures, including differences in decay rates and transcriptional regulation networks are discussed. We highlight the relative usefulness of different measures under different research questions, and consider what might be inferred from immune assays.</p>
Effects of ACTH4-10Pro8-Gly9-Pro10 on anti-inflammatory cytokine (IL-4, IL-10, IL-13) expression in acute spinal cord injury model (Sprague Dawley rats)
<p class="MsoNormal"><span><strong>Background:</strong> Spinal cord injury (SCI) is a destructive neurological and pathological state that causes major motor, sensory and autonomic dysfunctions. It's final neurological outcome determined from both primary and secondary injury process. Neuroinflammation is a key component of the secondary injury mechanisms with local and systemic consequences. </span>A neuroprotective compound, ACTH<sub>4-10</sub>Pro<sup>8</sup>-Gly<sup>9</sup>-Pro<sup>10 </sup>also known as Semax has <span>shown neuroprotective and anti-inflammatory properties. </span>ACTH<sub>4-10</sub>Pro<sup>8</sup>-Gly<sup>9</sup>-Pro<sup>10</sup> <span>also has actively used in the treatment of brain ischemia without serious complication reported. Here we analyzed the effects of </span>ACTH<sub>4-10</sub>Pro<sup>8</sup>-Gly<sup>9</sup>-Pro<sup>10</sup> in regulating inflammatory cascade in SCI by looking at the expression of anti-inflammatory cytokine IL-4, IL-10, IL-13 in acute compression SCI.</p> <p><span><strong>Method: </strong>We do laminectomy in Sprague Dawley rats at the second thoracic vertebrae. After laminectomy we expose the myelum and create mild SCI model with 20gr and severe SCI with 35gr aneurysm clips. </span>ACTH<sub>4-10</sub>Pro<sup>8</sup>-Gly<sup>9</sup>-Pro<sup>10 </sup><span>was administered intranasally to the treatment group and 0,9% NaCl to the control group (placebo). Both group was remain alive and terminated at 3 and 6 hour. </span>The preparations tissue sample were fixed in formalin and examined for immunohistochemistry<span>. Quantitative measurement of anti-inflammatory cytokine (</span>IL-4, IL-10, IL-13) was done in posterior horn with associated anti-monoclonal antibodies.</p> <p> </p> <p><strong>Result:</strong> Rats with mild SCI that were given ACTH<sub>4-10</sub>Pro<sup>8</sup>-Gly<sup>9</sup>-Pro<sup>10</sup> shown greater expression of IL-4, IL-10 and IL-13 at three hour post compression but only IL-10 and IL-13 elevated significantly at six hour. Rats with severe compression in ACTH<sub>4-10</sub>Pro<sup>8</sup>-Gly<sup>9</sup>-Pro<sup>10</sup> group shown greater expression of IL-10, IL-13 at three hour and IL-4, IL-10 at six hour compared with the placebo group.</p> <p> </p> <p><strong>Conclusion: </strong>Administration of ACTH<sub>4-10</sub>Pro<sup>8</sup>-Gly<sup>9</sup>-Pro<sup>10</sup> intranasal can increase anti inflammatory cytokine expression at Sprague Dawley rat model with mild and severe SCI. Expression of anti inflammatory cytokine was greater in mild compression and early hour (3 hour). Further research needs to be done to determine optimal dose and the actual clinical outcome in vivo.</p>
Effects of ACTH4-10Pro8-Gly9-Pro10 on anti-inflammatory cytokine (IL-4, IL-10, IL-13) expression in acute spinal cord injury model (Sprague Dawley rats)
Open the record for dataset details and reuse information.
Data from: Short-term sleep loss alters cytokine gene expression in brain and peripheral tissues and increases plasma corticosterone of zebra finch (Taeniopygia guttata)
Open the record for dataset details and reuse information.
Relationships between immune gene expression and circulating cytokine levels in wild house mice
Open the record for dataset details and reuse information.
CCL20 expression in human keratinocytes upon cytokine, pro-inflammatory, and UV stimuli.
Open the record for dataset details and reuse information.
Tonsillar Cytokine Expression After Allergen and/or Virus Intervention
ClinicalTrials.gov study NCT01924208. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Gene Expression Of Suppressor Of Cytokines in In Cutaneous Warts
ClinicalTrials.gov study NCT05781841. IPD Sharing: NO. Countries: 1. Publications: 1.
Expression of Pro- and Anti-inflammatory Cytokines During Anti-PCSK9 in Familial Hypercholesterolemia
ClinicalTrials.gov study NCT06231459. IPD Sharing: NO. Countries: 1. Publications: 1.
Characterization of Cytokines Expression During Enterovirus Meningitis in Paediatric Populations.
ClinicalTrials.gov study NCT04711876. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Clinical Outcome and Cytokine Expression After TKA
ClinicalTrials.gov study NCT03424174. IPD Sharing: NO. Countries: 1. Publications: 1.
Plasma microRNA Levels and Some Cytokines Expression in Patients With ITP Primary Immune Thrombocytopenic Purpura (ITP)
ClinicalTrials.gov study NCT05371743. IPD Sharing: NO. Countries: 1. Publications: 2.
Implantation and Cytokine Expression
ClinicalTrials.gov study NCT00264992. IPD Sharing: Not stated. Countries: 1. Publications: 2.
NFAT-Dependent Cytokine Gene Expression for Immune Monitoring in Kidney Transplant Patients
ClinicalTrials.gov study NCT01771705. IPD Sharing: Not stated. Countries: 1. Publications: 7.
Evaluation of Lymphocytic Infiltrate, Dendritic Cells and Cytokines Expression in Psoriatic Lesion and Normal Skin Before and After TNF Alfa Inhibitors Therapy
ClinicalTrials.gov study NCT01237262. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Nociceptors, Neurotrophic Factors and Cytokine Expression in Gastroesophageal Reflux Disease
ClinicalTrials.gov study NCT02114216. IPD Sharing: UNDECIDED. Countries: 1. Publications: 0.
Cytokine Expression During Radiation for Breast Cancer
ClinicalTrials.gov study NCT00836186. IPD Sharing: Not stated. Countries: 1. Publications: 0.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.