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Dataset results
9 results for “debranching”
Safety, Efficacy, Longitudinal Costs and Patient-Centered Outcomes Using a TAAA Debranching Device
ClinicalTrials.gov study NCT03637374. IPD Sharing: NO. Countries: 1. Publications: 1.
Source data for "Single-molecule analysis of actin filament debranching by cofilin and GMF"
<p>Source data for "Single-molecule analysis of actin filament debranching by cofilin and GMF"</p>
Preoperative/Neoadjuvant Therapy and Vascular Debranching Followed by Resection for Locally Advanced Pancreatic Cancer
ClinicalTrials.gov study NCT04136769. IPD Sharing: NO. Countries: 1. Publications: 1.
Evaluation of Supra-aortic Trunks Debranching Techniques in Open Arch Repair by Means of Frozen Elephant Trunk Procedure With Two Configurations of the Jotec E-Vita Hybrid Graft (FETOPT)
ClinicalTrials.gov study NCT03600077. IPD Sharing: NO. Countries: 1. Publications: 3.
Data from: Phylogenomic analysis of glycogen branching and debranching enzymatic duo
Branched polymers of glucose are universally used for energy storage in cells, taking the form of glycogen in animals, fungi, Bacteria, and Archaea, and of amylopectin in plants. Some enzymes involved in glycogen and amylopectin metabolism are similarly conserved in all forms of life, but some, interestingly, are not. In this paper we focus on phylogeny of glycogen branching and debranching enzymes, respectively involved in introducing and removing of the alpha(1->6) bonds in glucose polymers, bonds that provide the unique branching structure to glucose polymers. Results: We performed a large scale phylogenomic analysis of branching and debranching enzymes in over 400 completely sequenced genomes, including more than 200 from eukaryotes. We show that branching and debranching enzymes can be found in all kingdoms of life, including all major groups of eukaryotes, and thus were likely to have been present in the last universal common ancestor (LUCA) but have been lost in seemingly random fashion in numerous single celled eukaryotes. We also show how animal branching and debranching enzymes evolved from their LUCA ancestors by acquiring additional domains. Furthermore, we show that enzymes commonly perceived as orthologous, such as human branching enzyme GBE1 and E. coli branching enzyme glgB, are in fact related by a gene duplication and consequently paralogous. Conclusions: Despite its well known association with animal liver cells and plant starch, energy storage in the form of branched glucose polymers is clearly an ancient process and has been present in the earliest cells. The evolution of enzymes enabling this form of energy storage is more complex than previously thought and illustrates the need for explicit phylogenomic analysis in the study of even seemingly "simple" metabolic enzymes. Patterns of conservation and divergence in the evolution of the glycogen/starch branching and debranching enzymes have interesting biomedical connotations, as mutations in these enzymes lead to a variety of inheritable diseases in humans and other mammals.
Source Data for: VCP/p97-Associated Proteins are Binders and Debranching Enzymes of K48-K63-Branched Ubiquitin Chains
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Data from: Phylogenomic analysis of glycogen branching and debranching enzymatic duo
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Elucidating the role of glycogen debranching enzyme AGL in bladder carcinogenesis by generation and characterization of knockout mice
GEO Series GSE113158. Mus musculus. 8 samples. Type: Expression profiling by high throughput sequencing.
Debranching enzyme DBR1-mediated lariat RNA turnover requires ALBA proteins in Arabidopsis
GEO Series GSE284756. Arabidopsis thaliana. 57 samples. Type: Expression profiling by high throughput sequencing; Other.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.