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4 results for “defensive contributions”
Reduced stress defense responses contribute to the higher toxicity of a pesticide under warming
<p>There is a pressing need to identify the molecular mechanisms underlying the, often magnifying, interactive effects between contaminants and natural stressors. We here test our hypothesis that lower general stress defense responses contribute to synergistic interactions between stressors. We focus on the widespread pattern that many contaminants are more toxic at higher temperatures. Specifically, we tested the effects of an environmentally realistic low-effect and high-effect concentration of the pesticide chlorpyrifos under warming at the gene expression level in the Northern house mosquito <em>Culex pipiens molestus</em> (Forskal, 1775). By applying the independent action model for combined stressors on RNA-seq data, we identified interactive gene expression patterns under combined exposure to chlorpyrifos and warming for general stress defense responses: protection of macromolecules, antioxidant processes, detoxification, and energy metabolism/allocation. Most of these general stress defense response genes showed upregulated antagonistic interactions, i.e. were less upregulated than expected under the independent action model. This indicates that when pesticide exposure was combined with warming the general stress defense responses were no longer buffering increased stress levels, which may contribute to a higher sensitivity to toxicants under warming. These upregulated antagonistic interactions were stronger for the high-effect chlorpyrifos concentration, indicating that exposure to this concentration under warming was most stressful. Our results highlight that quantitative analysis of the frequency and strength of the interaction types of general stress defense response genes, specifically focusing on antagonistic upregulations and synergistic downregulations, may advance understanding of how natural stressors modify the toxicity of contaminants.</p>
Reduced stress defense responses contribute to the higher toxicity of a pesticide under warming
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Alterations to hormone regulated defense and stress response networks contribute to the greater growth of Arabidopsis F1 hybrids
GEO Series GSE64475. Arabidopsis thaliana. 34 samples. Type: Expression profiling by high throughput sequencing.
Extracellular traps released by antimicrobial TH17 cells contributes to host defense
GEO Series GSE144852. Homo sapiens. 37 samples. Type: Expression profiling by high throughput sequencing.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.